YRC Public Data Repository - Protein Structure Prediction

Protein:	HRQ1
Organism:	Saccharomyces cerevisiae
Length:	1077 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HRQ1.

Description	E-value	Query Range	Subject Range
HRQ1_YEAST - ATP-dependent helicase HRQ1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HRQ1 PE=1 SV... HRQ1 - Putative RecQ helicase; belongs to the widely conserved RecQ family of proteins which are involved i... gi\|190404766 - gi\|190404766\|gb\|EDV08033.1\| DNA helicase [Saccharomyces cerevisiae RM11-1a] gi\|151942263 - gi\|151942263\|gb\|EDN60619.1\| DNA helicase [Saccharomyces cerevisiae YJM789]	0.0	[1..1077]	[1..1077]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[218..1014]	[15..802]
gi\|19551557, gi\|... - gi\|21323071\|dbj\|BAB97700.1\| Distinct helicase family with a unique C-terminal domain including a met...	0.0	[238..1010]	[2..775]
gi\|25486653 - pir\|\|D83870 ATP-dependent RNA helicase BH1764 [imported] - Bacillus halodurans (strain C-125) gi\|15614327, gi\|... - gi\|15614327\|ref\|NP_242630.1\| ATP-dependent RNA helicase [Bacillus halodurans C-125], gi\|10174382\|dbj...	0.0	[240..997]	[5..742]
gi\|18313246, gi\|... - gi\|18313246\|ref\|NP_559913.1\| ATP-dependent helicase [Pyrobaculum aerophilum str. IM2], gi\|18160766\|g...	0.0	[281..1014]	[42..726]
gi\|7446114 - pir\|\|B70564 hypothetical protein Rv3649 - Mycobacterium tuberculosis (strain H37RV) gi\|2105045, gi\|1... - gi\|2105045\|emb\|CAB08839.1\| PROBABLE HELICASE [Mycobacterium tuberculosis H37Rv], gi\|15610785\|ref\|NP_... gi\|253800689, gi... - gi\|253800689\|ref\|YP_003033690.1\| helicase [Mycobacterium tuberculosis KZN 1435], gi\|253322192\|gb\|ACT... gi\|254552761 - gi\|254552761\|ref\|ZP_05143208.1\| helicase [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] gi\|148824851, gi... - gi\|76782589\|ref\|ZP_00769793.1\| COG1205: Distinct helicase family with a unique C-terminal domain inc... gi\|254818129 - gi\|254818129\|ref\|ZP_05223130.1\| helicase [Mycobacterium tuberculosis KZN 4207] gi\|194542196, gi... - gi\|81252882\|ref\|ZP_00877457.1\| COG1205: Distinct helicase family with a unique C-terminal domain inc... gi\|255095046 - gi\|255095046\|ref\|ZP_05324524.1\| helicase [Mycobacterium tuberculosis KZN 605] gi\|134151711, gi... - gi\|254366199\|ref\|ZP_04982243.1\| hypothetical helicase [Mycobacterium tuberculosis str. Haarlem], gi\|... gi\|148663512, gi... - gi\|148663512\|ref\|YP_001285035.1\| DeaD/DeaH box family ATP-dependent RNA helicase [Mycobacterium tube...	0.0	[260..1020]	[25..770]
gi\|15843261, gi\|... - gi\|15843261\|ref\|NP_338298.1\| DEAD-box ATP dependent DNA helicase [Mycobacterium tuberculosis CDC1551...	0.0	[260..1020]	[25..770]
gi\|2621563, gi\|1... - gi\|2621563\|gb\|AAB84998.1\| ATP-dependent RNA helicase, eIF-4A family [Methanothermobacter thermautotr... gi\|7446099 - pir\|\|F69164 ATP-dependent RNA helicase homolog MTH492 - Methanobacterium thermoautotrophicum (strain...	0.0	[246..1016]	[7..746]
YPRA_BACSU - Uncharacterized ATP-dependent helicase YprA OS=Bacillus subtilis (strain 168) GN=yprA PE=3 SV=1 gi\|221323658 - gi\|221323658\|ref\|ZP_03604952.1\| hypothetical protein BsubsS_12202 [Bacillus subtilis subsp. subtilis... YPRA_BACSU - Uncharacterized ATP-dependent helicase yprA OS=Bacillus subtilis GN=yprA PE=3 SV=1 gi\|221314460 - gi\|221314460\|ref\|ZP_03596265.1\| hypothetical protein BsubsN3_12147 [Bacillus subtilis subsp. subtili... gi\|221319382 - gi\|221319382\|ref\|ZP_03600676.1\| hypothetical protein BsubsJ_12073 [Bacillus subtilis subsp. subtilis...	0.0	[237..989]	[2..728]
gi\|15922649, gi\|... - gi\|15922649\|ref\|NP_378318.1\| hypothetical protein ST2317 [Sulfolobus tokodaii str. 7], gi\|15623439\|d...	0.0	[245..1027]	[20..744]

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Predicted Domain #1

Region A:
Residues: [1-255]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEEGPIKKKL KSAGQGSGKT DAFRNFEQFF FRLNTLYTFL ICRKHVVPTF KTLCGPIETA  60
   61 LKRTVTKEDL AMVMALMPRE CVFKYIDENQ IYTETKIFDF NNGGFQQKEN DIFELKDVDD 120
  121 QNQTQKSTQL LIFEFIDGTM QRSWSASDRF SQIKIPTYTT EEMKKMISKR EALFKSRLRE 180
  181 FILEKEKANL DPFSELTNLA QKYIPRERDY EDPIEAMMKA KQESNEMSIP NYSNNSVITT 240
  241 IPQMIEKLKS TEFYA

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	2.23442113662155	bayes_pls_golite062009
nucleic acid binding	2.22122084731597	bayes_pls_golite062009
DNA binding	2.16885651648653	bayes_pls_golite062009
binding	1.98377446854662	bayes_pls_golite062009
transcription factor activity	1.44593900614628	bayes_pls_golite062009
sequence-specific DNA binding	0.289025912917599	bayes_pls_golite062009
transcription activator activity	0.119156260169142	bayes_pls_golite062009
transcription repressor activity	0.0014623387970365	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [256-732]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQIKHCFTIP SRTAKYKGLC FELAPEVYQG MEHENFYSHQ ADAINSLHQG ENVIITTSTS  60
   61 SGKSLIYQLA AIDLLLKDPE STFMYIFPTK ALAQDQKRAF KVILSKIPEL KNAVVDTYDG 120
  121 DTEPEERAYI RKNARVIFTN PDMIHTSILP NHANWRHFLY HLKLVVVDEL HIYKGLFGSH 180
  181 VALVMRRLLR LCHCFYENSG LQFISCSATL KSPVQHMKDM FGINEVTLIH EDGSPTGAKH 240
  241 LVVWNPPILP QHERKRENFI RESAKILVQL ILNNVRTIAF CYVRRVCELL MKEVRNIFIE 300
  301 TGREDLVTEV MSYRGGYSAS DRRKIEREMF HGNLKAVIST NALELGIDIG GLDAVLMCGF 360
  361 PLSMANFHQQ SGRAGRRNND SLTLVVASDS PVDQHYVAHP ESLLEVNNFE SYQDLVLDFN 420
  421 NILILEGHIQ CAAFELPINF ERDKQYFTES HLRKICVERL HHNQDGYHAS NRFLPWP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	90.39794
Match:	1fuuA_
Description:	Initiation factor 4a
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [733-883]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKCVSLRGGE EDQFAVVDIT NGRNIIIEEI EASRTSFTLY DGGIFIHQGY PYLVKEFNPD  60
   61 ERYAKVQRVD VDWVTNQRDF TDVDPQEIEL IRSLRNSDVP VYFGKIKTTI IVFGFFKVDK 120
  121 YKRIIDAIET HNPPVIINSK GLWIDMPKYA L

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [884-1077]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EICQKKQLNV AGAIHGAQHA IMGMLPRFIV AGVDEIQTEC KAPEKEFAER QTKRKRPARL  60
   61 IFYDSKGGKY GSGLCVKAFE HIDDIIESSL RRIEECPCSD GCPDCVAASF CKENSLVLSK 120
  121 PGAQVVLHCI LGHSEDSFID LIKDGPEPNM PEIKVETVIP VSEHVNFSDD FKIIDVRRAT 180
  181 KDDTHTNEII KKEI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [831-1015]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPVYFGKIKT TIIVFGFFKV DKYKRIIDAI ETHNPPVIIN SKGLWIDMPK YALEICQKKQ  60
   61 LNVAGAIHGA QHAIMGMLPR FIVAGVDEIQ TECKAPEKEF AERQTKRKRP ARLIFYDSKG 120
  121 GKYGSGLCVK AFEHIDDIIE SSLRRIEECP CSDGCPDCVA ASFCKENSLV LSKPGAQVVL 180
  181 HCILG

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	36.136677
Match:	PF09369.1
Description:	No description for PF09369.1 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [1016-1077]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSEDSFIDLI KDGPEPNMPE IKVETVIPVS EHVNFSDDFK IIDVRRATKD DTHTNEIIKK  60
   61 EI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: