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View Structure Prediction Details

Protein: MSS4
Organism: Saccharomyces cerevisiae
Length: 779 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSS4.

Description E-value Query
Range
Subject
Range
MSS4_YEAST - Probable phosphatidylinositol 4-phosphate 5-kinase MSS4 OS=Saccharomyces cerevisiae (strain ATCC 204...
MSS4 - Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morp...
0.0 [1..779] [1..779]
its3 - 1-phosphatidylinositol-4-phosphate 5-kinase Its3
ITS3_SCHPO - Phosphatidylinositol 4-phosphate 5-kinase its3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843...
0.0 [163..770] [19..678]
PIP5K1A - phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
0.0 [327..766] [24..465]
gi|147904449, gi... - gi|18482454|gb|AAL68954.1| phosphatidylinositol-4-phosphate 5-kinase [Xenopus laevis], gi|147904449|...
0.0 [317..768] [3..438]
gi|148699483, gi... - gi|74191790|dbj|BAE32849.1| unnamed protein product [Mus musculus], gi|74143040|dbj|BAE42536.1| unna...
0.0 [313..757] [7..444]
gi|3288870 - gi|3288870|gb|AAC25576.1| phosphatidylinositol 4-phosphate 5-kinase [Drosophila melanogaster]
0.0 [277..774] [51..597]

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Predicted Domain #1
Region A:
Residues: [1-299]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVLRSQPPS VVPLHLTTST SRKTEQEPSL LHSAIIERHQ DRSVPNSNSN PDSNHRIKKD  60
   61 RNNHTSYHSS SNSESNMESP RLSDGESSTP TSIEELNPTI NNSRLVKRNY SISIDPLHDN 120
  121 SNNNTDDDHP NTITSPRPNS TSNKEMQKYS FPEGKESKKI TTPSLNSNNC LDLDNSSLVH 180
  181 TDSYIQDLND DHILLNKRVS RRSSRISAVT ATSTTIKQRR NTQDSNLPNI PFHASKHSQI 240
  241 LPMDDSDVIK LANGDTSMKP NSATKISHSM TSLPLHPLPQ PSQKSKQYHM ISKSTTSLP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [300-556]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PENDHYYQHS RGTNHNHAAN AAAVNNNTTT TTAATGLKRS ESATAEIKKM RQSLLHKREM  60
   61 KRKRKTFLVD DDRVLIGNKV SEGHVNFIIA YNMLTGIRVA VSRCSGIMKP LTPADFRFTK 120
  121 KLAFDYHGNE LTPSSQYAFK FKDYCPEVFR ELRALFGLDP ADYLVSLTSK YILSELNSPG 180
  181 KSGSFFYYSR DYKYIIKTIH HSEHIHLRKH IQEYYNHVRD NPNTLICQFY GLHRVKMPIS 240
  241 FQNKIKHRKI YFLVMNN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 481.228787
Match: 1bo1A_
Description: Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
inositol or phosphatidylinositol kinase activity 4.31726963575315 bayes_pls_golite062009
lipid kinase activity 3.63026201392483 bayes_pls_golite062009
phosphatidylinositol phosphate kinase activity 3.5005619620026 bayes_pls_golite062009
1-phosphatidylinositol-4-phosphate 5-kinase activity 3.00599233846946 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.8512866333787 bayes_pls_golite062009
kinase activity 2.68971389233526 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.48646215276903 bayes_pls_golite062009
catalytic activity 1.87792712964225 bayes_pls_golite062009
binding 1.66593042987179 bayes_pls_golite062009
transferase activity 1.20817067352467 bayes_pls_golite062009
signal transducer activity 1.15068527302487 bayes_pls_golite062009
molecular transducer activity 1.15068527302487 bayes_pls_golite062009
protein kinase activity 0.709372924978886 bayes_pls_golite062009
acid-amino acid ligase activity 0.489382280175196 bayes_pls_golite062009
ligase activity 0.435608917599349 bayes_pls_golite062009
protein binding 0.382966234080422 bayes_pls_golite062009
protein serine/threonine kinase activity 0.189737258618863 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [557-779]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LFPPHLDIHI TYDLKGSTWG RFTNLDKERL AKDRSYRPVM KDLNWLEEGQ KIKFGPLKKK  60
   61 TFLTQLKKDV ELLAKLNTMD YSLLIGIHDI NKAKEDDLQL ADTASIEEQP QTQGPIRTGT 120
  121 GTVVRHFFRE FEGGIRASDQ FNNDVDLIYY VGIIDFLTNY SVMKKLETFW RSLRHDTKLV 180
  181 SAIPPRDYAN RFYEFIEDSV DPLPQKKTQS SYRDDPNQKN YKD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 481.228787
Match: 1bo1A_
Description: Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle