YRC Public Data Repository - Protein Structure Prediction

Protein:	CPR1
Organism:	Saccharomyces cerevisiae
Length:	162 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CPR1.

Description	E-value	Query Range	Subject Range
gi\|82491991 - gi\|82491991\|gb\|ABB77877.1\| peptidylprolyl isomerase A [Gorilla gorilla] PPIA_HYLLA - Peptidyl-prolyl cis-trans isomerase A OS=Hylobates lar GN=PPIA PE=3 SV=3 PPIA_NOMLE - Peptidyl-prolyl cis-trans isomerase A OS=Nomascus leucogenys GN=PPIA PE=3 SV=3 PPIA_SYMSY - Peptidyl-prolyl cis-trans isomerase A OS=Symphalangus syndactylus GN=PPIA PE=3 SV=3 PPIA_GORGO - Peptidyl-prolyl cis-trans isomerase A OS=Gorilla gorilla gorilla GN=PPIA PE=3 SV=3 PPIA_PAPAN - Peptidyl-prolyl cis-trans isomerase A OS=Papio anubis GN=PPIA PE=2 SV=2 gi\|2565299 - gi\|2565299\|gb\|AAB81959.1\| cyclophilin A [Papio hamadryas] gi\|208967012, gi... - gi\|208967012\|dbj\|BAG73520.1\| peptidylprolyl isomerase A [synthetic construct], gi\|123998379\|gb\|ABM86... PPIA_CHLAE - Peptidyl-prolyl cis-trans isomerase A OS=Chlorocebus aethiops GN=PPIA PE=2 SV=2 gi\|90075960 - gi\|90075960\|dbj\|BAE87660.1\| unnamed protein product [Macaca fascicularis] PPIA - peptidylprolyl isomerase A (cyclophilin A) PPIA_MACMU - Peptidyl-prolyl cis-trans isomerase A OS=Macaca mulatta GN=PPIA PE=1 SV=2 gi\|31615579, gi\|... - gi\|31615580\|pdb\|1M9Y\|F Chain F, X-Ray Crystal Structure Of Cyclophilin AHIV-1 Ca N- Terminal Domain ... PPIA_PANPA - Peptidyl-prolyl cis-trans isomerase A OS=Pan paniscus GN=PPIA PE=3 SV=3 PPIA_PANTR - Peptidyl-prolyl cis-trans isomerase A OS=Pan troglodytes GN=PPIA PE=3 SV=3 PPIA_PONPY - Peptidyl-prolyl cis-trans isomerase A OS=Pongo pygmaeus GN=PPIA PE=2 SV=4	3.0E-82	[2..162]	[4..164]
gi\|2981756, gi\|2... - gi\|2981756\|pdb\|1AWT\|L Chain L, Secypa Complexed With Hagpia, gi\|2981755\|pdb\|1AWT\|K Chain K, Secypa C... gi\|2981751\|pdb\|1... - Chain J, Cypa Complexed With Hagpia, Chain L, Cypa Complexed With Hagpia, Chain I, Cypa Complexed Wi...	3.0E-82	[2..162]	[3..163]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	8.0E-82	[2..162]	[3..163]
gi\|118098, gi\|49496 - gi\|49496\|emb\|CAA34961.1\| unnamed protein product [Cricetulus longicaudatus], sp\|P14851\|PPIA_CRILO Pe... PPIA_CRIGR - Peptidyl-prolyl cis-trans isomerase A OS=Cricetulus griseus GN=PPIA PE=2 SV=2	6.0E-81	[2..162]	[4..164]
gi\|29028316 - gi\|29028316\|gb\|AAO64722.1\|AF022115_1 cyclophilin [Homo sapiens] gi\|51980547 - gb\|AAH82162.1\| Unknown (protein for MGC:98498) [Xenopus laevis] PPIA_MOUSE - Peptidyl-prolyl cis-trans isomerase A OS=Mus musculus GN=Ppia PE=1 SV=2	1.0E-80	[2..162]	[4..164]
PPIA_RABIT - Peptidyl-prolyl cis-trans isomerase A OS=Oryctolagus cuniculus GN=PPIA PE=2 SV=3	1.0E-80	[2..162]	[4..164]

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Predicted Domain #1

Region A:
Residues: [1-162]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQVYFDVEA DGQPIGRVVF KLYNDIVPKT AENFRALCTG EKGFGYAGSP FHRVIPDFML  60
   61 QGGDFTAGNG TGGKSIYGGK FPDENFKKHH DRPGLLSMAN AGPNTNGSQF FITTVPCPWL 120
  121 DGKHVVFGEV VDGYDIVKKV ESLGSPSGAT KARIVVAKSG EL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	633.9691
Match:	1ak4A_
Description:	Cyclophilin (eukaryotic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein deacetylase activity	4.3775483906311	bayes_pls_golite062009
histone deacetylase activity	4.29026678196473	bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity	3.73853378771688	bayes_pls_golite062009
cis-trans isomerase activity	3.66963215732405	bayes_pls_golite062009
deacetylase activity	3.49940864924766	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	3.01511519120932	bayes_pls_golite062009
RNA binding	2.94609837984526	bayes_pls_golite062009
isomerase activity	1.96529188741504	bayes_pls_golite062009
binding	1.46018233647024	bayes_pls_golite062009
mRNA binding	1.45537055700871	bayes_pls_golite062009
unfolded protein binding	1.38124355054041	bayes_pls_golite062009
nucleic acid binding	0.939772862764466	bayes_pls_golite062009
catalytic activity	0.748655649755714	bayes_pls_golite062009
hydrolase activity	0.493806105600863	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.408539130322443	bayes_pls_golite062009
drug binding	0.36339132904137	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.322244688184474	bayes_pls_golite062009
small conjugating protein ligase activity	0.286133802341887	bayes_pls_golite062009
histone binding	0.268719695649015	bayes_pls_golite062009
protein binding	0.130251391659493	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: