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View Structure Prediction Details

Protein: ECM18
Organism: Saccharomyces cerevisiae
Length: 453 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ECM18.

Description E-value Query
Range
Subject
Range
ECM18_YEAST - Protein ECM18 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ECM18 PE=1 SV=1
gi|190404913 - gi|190404913|gb|EDV08180.1| extracellular matrix protein 18 [Saccharomyces cerevisiae RM11-1a]
gi|207346710 - gi|207346710|gb|EDZ73128.1| YDR125Cp-like protein [Saccharomyces cerevisiae AWRI1631]
ECM18 - Protein of unknown function, similar to Rlp24p
2.0E-91 [1..453] [1..453]
CE08627 - status:Partially_confirmed UniProt:P91141 protein_id:AAB42367.1
9.0E-55 [9..448] [28..423]
gi|7268994, gi|2... - pir||T01316 epoxide hydrolase homolog T14P8.15 - Arabidopsis thaliana, gi|7268994|emb|CAB80727.1| AT...
3.0E-51 [107..447] [6..314]
gi|215717145, gi... - gi|6016858|dbj|BAA85201.1| putative epoxide hydrolase [Oryza sativa Japonica Group], gi|5922625|dbj|...
4.0E-51 [114..447] [16..320]
gi|10197684 - gi|10197684|gb|AAG14968.1|AF233336_1 soluble epoxide hydrolase [Homo sapiens]
1.0E-50 [81..453] [205..550]

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Predicted Domain #1
Region A:
Residues: [1-77]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLIKRYLMD PESLRRQIMN VYKCYMWKRA FHSNRSLLEV KRREKSLQRK ILERILRPKE  60
   61 ENAVKKSGFK LWSSHLN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.909 a.112.1 Description not found.

Predicted functions:

Term Confidence Notes
catalytic activity 1.39629727416851 bayes_pls_golite062009
phospholipase activity 1.05835015160042 bayes_pls_golite062009
lipase activity 0.849473630399459 bayes_pls_golite062009
carboxylesterase activity 0.424330502936163 bayes_pls_golite062009
binding 0.401633301499824 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.264183693934251 bayes_pls_golite062009
protein binding 0.0473186402188429 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [78-453]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPHKTYMRLE ELQRRIMEEV HVEGIKKNDK LFNEINQWHF QNENTSTVRT PTLLIHGYAA  60
   61 SSMSFFRNYP GLSKHIRNLY SIDMPASGLS SVPSLEINTT TPLPLDIKFI GENKFKVPYT 120
  121 INANHNKFVI QMYEDFYLDR IEQWRIDNKL GKMNVVGHSF GGYLSFKYAV KYPNSVNKLC 180
  181 LVSPLGVERN IWSVNNNFHS NTLYTIDFKN PNSKFYSKRN MIPKYLFEQQ FHILRMMGPL 240
  241 GAKLCWNYIM AAYSRVPSLA YKEYIFELFY GKGGIPEVTT DIFKALFSRC ILAKDPLMDS 300
  301 LQYLNVKKLL IVYGQYDWMN KKAGMFMVKE LNNLKNCLEG ASYLEIPSSG HNLFLDNPES 360
  361 FNQSIVSFLS DETKSP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.09691
Match: 1cqzA_
Description: Epoxide hydrolase, N-terminal domain; Mammalian epoxide hydrolase, C-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle