YRC Public Data Repository - Protein Structure Prediction

Protein:	GUD1
Organism:	Saccharomyces cerevisiae
Length:	489 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GUD1.

Description	E-value	Query Range	Subject Range
gi\|190405226 - gi\|190405226\|gb\|EDV08493.1\| guanine deaminase [Saccharomyces cerevisiae RM11-1a] GUD1 - Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia ... GUAD_YEAST - Probable guanine deaminase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GUD1 PE=1 SV=...	1.0E-90	[1..489]	[1..489]
GUAD_MOUSE - Guanine deaminase OS=Mus musculus GN=Gda PE=1 SV=1 gi\|20270692 - gi\|20270692\|gb\|AAM18372.1\|AF369883_1 guanine deaminase [Mus musculus molossinus] gi\|20270694 - gi\|20270694\|gb\|AAM18373.1\|AF369884_1 guanine deaminase [Mus musculus castaneus]	3.0E-75	[11..486]	[3..447]
gi\|169890281, gi... - gi\|170082446\|ref\|YP_001731766.1\| guanine deaminase [Escherichia coli str. K-12 substr. DH10B], gi\|16... gi\|85675696, gi\|... - gi\|89109663\|ref\|AP_003443.1\| guanine deaminase [Escherichia coli str. K-12 substr. W3110], gi\|856756... EG13066 - guanine deaminase / Guanine deaminase GUAD_ECOLI - Guanine deaminase (EC 3.5.4.3) (Guanase) (Guanine aminase) (Guanine aminohydrolase) (GAH) - Escheric... gi\|238861395, gi... - gi\|238902009\|ref\|YP_002927805.1\| guanine deaminase [Escherichia coli BW2952], gi\|238861395\|gb\|ACR633... EG13066 - guanine deaminase / Guanine deaminase	7.0E-75	[32..488]	[30..437]
gi\|887833 - gi\|887833\|gb\|AAA83064.1\| ORF_o439	1.0E-74	[32..488]	[30..437]
gi\|209760658, gi... - pir\|\|D91098 hypothetical protein ECs3756 [imported] - Escherichia coli (strain O157:H7, substrain R... gi\|15833010, gi\|... - gi\|15833010\|ref\|NP_311783.1\| guanine deaminase [Escherichia coli O157:H7], gi\|13363228\|dbj\|BAB37179.... gi\|15833010, gi\|... - gi\|15833010\|ref\|NP_311783.1\| guanine deaminase [Escherichia coli O157:H7 str. Sakai], gi\|13363228\|db...	2.0E-74	[32..488]	[30..437]
gi\|12517407, gi\|... - gi\|15803420\|ref\|NP_289453.1\| guanine deaminase [Escherichia coli O157:H7 EDL933], gi\|12517407\|gb\|AAG... gi\|25329019 - pir\|\|H85943 hypothetical protein ygfP [imported] - Escherichia coli (strain O157:H7, substrain EDL9...	3.0E-74	[32..488]	[30..437]
gi\|10336584 - gi\|10336584\|dbj\|BAB13788.1\| urease alpha subunit UreC [Vibrio parahaemolyticus]	5.0E-73	[1..480]	[55..488]
gi\|149062581, gi... - gi\|7533042\|gb\|AAF63337.1\|AF245172_1 guanine deaminase [Rattus norvegicus], gi\|149062581\|gb\|EDM13004....	5.0E-73	[11..486]	[3..447]
gi\|163842641, gi... - gi\|163842641\|ref\|YP_001627045.1\| guanine deaminase [Brucella suis ATCC 23445], gi\|163673364\|gb\|ABY37... gi\|17987854, gi\|... - gi\|17987854\|ref\|NP_540488.1\| guanine deaminase [Brucella melitensis 16M], gi\|17983584\|gb\|AAL52752.1\|... gi\|25526844 - pir\|\|AE3448 guanine deaminase (EC 3.5.4.3) [imported] - Brucella melitensis (strain 16M) gi\|23501259, gi\|... - gi\|23501259\|ref\|NP_697386.1\| guanine deaminase [Brucella suis 1330], gi\|23347144\|gb\|AAN29301.1\| chlo... gi\|254701170 - gi\|254701170\|ref\|ZP_05162998.1\| guanine deaminase [Brucella suis bv. 5 str. 513]	5.0E-73	[16..487]	[8..430]

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Predicted Domain #1

Region A:
Residues: [1-22]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKSDLLFDK FNDKHGKFLV FF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [41-86]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVGVLNGIIR FVNRNSLDPV KDCLDHDSSL SPEDVTVVDI IGKDKT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.69897
Match:	1ubpC_
Description:	alpha-Subunit of urease; alpha-subunit of urease, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
guanine deaminase activity	3.78802420851729	bayes_pls_golite062009
hydrolase activity	3.06979421893431	bayes_pls_golite062009
adenine deaminase activity	1.93704109004145	bayes_pls_golite062009
deaminase activity	1.79186203771221	bayes_pls_golite062009
catalytic activity	1.70199291046899	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1.60895003474033	bayes_pls_golite062009
dihydropyrimidinase activity	1.51712244686012	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	0.787370269329878	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.573107361273483	bayes_pls_golite062009
peptidase activity	0.483675247391628	bayes_pls_golite062009
dihydroorotase activity	0.203044795244555	bayes_pls_golite062009
binding	0.131274900913166	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.0644988334012029	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [23-40]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTFVDTPKLG ELRIREKT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [87-489]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNNSFYFPGF VDTHNHVSQY PNVGVFGNST LLDWLEKYTF PIEAALANEN IAREVYNKVI  60
   61 SKTLSHGTTT VAYYNTIDLK STKLLAQLSS LLGQRVLVGK VCMDTNGPEY YIEDTKTSFE 120
  121 STVKVVKYIR ETICDPLVNP IVTPRFAPSC SRELMQQLSK LVKDENIHVQ THLSENKEEI 180
  181 QWVQDLFPEC ESYTDVYDKY GLLTEKTVLA HCIHLTDAEA RVIKQRRCGI SHCPISNSSL 240
  241 TSGECRVRWL LDQGIKVGLG TDVSAGHSCS ILTTGRQAFA VSRHLAMRET DHAKLSVSEC 300
  301 LFLATMGGAQ VLRMDETLGT FDVGKQFDAQ MIDTNAPGSN VDMFHWQLKE KDQMQEQEQE 360
  361 QGQDPYKNPP LLTNEDIIAK WFFNGDDRNT TKVWVAGQQV YQI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.69897
Match:	1ubpC_
Description:	alpha-Subunit of urease; alpha-subunit of urease, catalytic domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: