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View Structure Prediction Details

Protein: RGT2
Organism: Saccharomyces cerevisiae
Length: 763 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RGT2.

Description E-value Query
Range
Subject
Range
RGT2 - Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmem...
RGT2_YEAST - High-affinity glucose transporter RGT2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=R...
0.0 [1..763] [1..763]
gi|2440082 - gi|2440082|emb|CAA75114.1| putative glucose sensor [Kluyveromyces lactis]
0.0 [84..761] [3..714]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [56..615] [16..570]

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Predicted Domain #1
Region A:
Residues: [1-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDSQNCLRQ REENSHLNPG NDFGHHQGAE CTINHNNMPH RNAYTESTND TEAKSIVMCD  60
   61 DPNAYQISYT NN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [73-287]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPAGDGAIET TSILLSQPLP LRSNVMSVLV GIFVAVGGFL FGYDTGLINS ITDMPYVKTY  60
   61 IAPNHSYFTT SQIAILVSFL SLGTFFGALI APYISDSYGR KPTIMFSTAV IFSIGNSLQV 120
  121 ASGGLVLLIV GRVISGIGIG IISAVVPLYQ AEAAQKNLRG AIISSYQWAI TIGLLVSSAV 180
  181 SQGTHSKNGP SSYRIPIGLQ YVWSSILAVG MIFLP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [336-548]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGPSTLLDCF KTSENRPKQI LRIFTGIAIQ AFQQASGINF IFYYGVNFFN NTGVDNSYLV  60
   61 SFISYAVNVA FSIPGMYLVD RIGRRPVLLA GGVIMAIANL VIAIVGVSEG KTVVASKIMI 120
  121 AFICLFIAAF SATWGGVVWV VSAELYPLGV RSKCTAICAA ANWLVNFTCA LITPYIVDVG 180
  181 SHTSSMGPKI FFIWGGLNVV AVIVVYFAVY ETR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 539.9897
Match: 1ja5A_
Description: No description for 1ja5A_ was found.

Predicted functions:

Term Confidence Notes
glycerol transmembrane transporter activity 7.11654923455995 bayes_pls_golite062009
alcohol transmembrane transporter activity 6.7545566917184 bayes_pls_golite062009
polyol transmembrane transporter activity 6.7545566917184 bayes_pls_golite062009
glycerol-3-phosphate transmembrane transporter activity 5.74077413704789 bayes_pls_golite062009
transporter activity 4.09176719149278 bayes_pls_golite062009
substrate-specific transporter activity 3.59744164024479 bayes_pls_golite062009
transmembrane transporter activity 3.5865018981083 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.54194478414824 bayes_pls_golite062009
hexose phosphate transmembrane transporter activity 3.3746965264994 bayes_pls_golite062009
glucose-6-phosphate transmembrane transporter activity 3.3746965264994 bayes_pls_golite062009
sugar:hydrogen symporter activity 2.99050613058546 bayes_pls_golite062009
cation:sugar symporter activity 2.99050613058546 bayes_pls_golite062009
monosaccharide transmembrane transporter activity 2.63293544825311 bayes_pls_golite062009
carbohydrate transmembrane transporter activity 2.62141276633776 bayes_pls_golite062009
sugar transmembrane transporter activity 2.47557586092261 bayes_pls_golite062009
ion transmembrane transporter activity 2.21266150105753 bayes_pls_golite062009
solute:hydrogen symporter activity 2.10485633822652 bayes_pls_golite062009
binding 1.89539096965643 bayes_pls_golite062009
cation transmembrane transporter activity 1.79369588808394 bayes_pls_golite062009
active transmembrane transporter activity 1.59419818573076 bayes_pls_golite062009
secondary active transmembrane transporter activity 1.22264637452409 bayes_pls_golite062009
symporter activity 0.74591237387473 bayes_pls_golite062009
solute:cation symporter activity 0.74591237387473 bayes_pls_golite062009
sugar binding 0.285073104957756 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [288-335]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESPRYYVLKD ELNKAAKSLS FLRGLPIEDP RLLEELVEIK ATYDYEAS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [549-619]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLTLEEIDEL FRKAPNSVIS SKWNKKIRKR CLAFPISQQI EMKTNIKNAG KLDNNNSPIV  60
   61 QDDSHNIIDV D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 539.9897
Match: 1ja5A_
Description: No description for 1ja5A_ was found.

Predicted Domain #4
Region A:
Residues: [620-763]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFLENQIQSN DHMIAADKGS GSLVNIIDTA PLTSTEFKPV EHPPVNYVDL GNGLGLNTYN  60
   61 RGPPSIISDS TDEFYEENDS SYYNNNTERN GANSVNTYMA QLINSSSTTS NDTSFSPSHN 120
  121 SNARTSSNWT SDLASKHSQY TSPQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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