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View Structure Prediction Details

Protein: IDP1
Organism: Saccharomyces cerevisiae
Length: 428 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IDP1.

Description E-value Query
Range		 Subject
Range
gi|169989 - gi|169989|gb|AAA33978.1| NADPH-specific isocitrate dehydrogenase
 0.0 [5..426] [20..441]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [5..426] [30..451]
IDHP_MEDSA - Isocitrate dehydrogenase [NADP], chloroplastic (Fragment) OS=Medicago sativa PE=2 SV=1
 0.0 [11..426] [18..433]
IDHC_TOBAC - Isocitrate dehydrogenase [NADP] OS=Nicotiana tabacum PE=2 SV=1
 0.0 [15..428] [1..414]
gi|190405075 - gi|190405075|gb|EDV08342.1| NADP-dependent isocitrate dehydrogenase [Saccharomyces cerevisiae RM11-1...
gi|207346964 - gi|207346964|gb|EDZ73297.1| YDL066Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|151941934 - gi|151941934|gb|EDN60290.1| NADP-dependent isocitrate dehydrogenase [Saccharomyces cerevisiae YJM789...
IDP1 - Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha...
IDHP_YEAST - Isocitrate dehydrogenase [NADP], mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S28...
 0.0 [1..428] [1..428]
gi|125595294, gi... - gi|52353538|gb|AAU44104.1| isocitrate dehydrogenase [Oryza sativa Japonica Group], gi|222632636|gb|E...
gi|5007086 - gi|5007086|gb|AAD37810.1|AF155334_1 NADP-specific isocitrate dehydrogenase [Oryza sativa]
 0.0 [15..426] [1..411]
gi|1750380 - gi|1750380|gb|AAB39248.1| NADP-isocitrate dehydrogenase [Eucalyptus globulus]
 0.0 [15..425] [1..411]
gi|3811007 - gi|3811007|dbj|BAA34112.1| NADP specific isocitrate dehydrogenase [Daucus carota]
 0.0 [15..426] [1..412]

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Predicted Domain #1
Region A:
Residues: [1-428] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSMLSRRLFS TSRLAAFSKI KVKQPVVELD GDEMTRIIWD KIKKKLILPY LDVDLKYYDL  60
   61 SVESRDATSD KITQDAAEAI KKYGVGIKCA TITPDEARVK EFNLHKMWKS PNGTIRNILG 120
  121 GTVFREPIVI PRIPRLVPRW EKPIIIGRHA HGDQYKATDT LIPGPGSLEL VYKPSDPTTA 180
  181 QPQTLKVYDY KGSGVAMAMY NTDESIEGFA HSSFKLAIDK KLNLFLSTKN TILKKYDGRF 240
  241 KDIFQEVYEA QYKSKFEQLG IHYEHRLIDD MVAQMIKSKG GFIMALKNYD GDVQSDIVAQ 300
  301 GFGSLGLMTS ILVTPDGKTF ESEAAHGTVT RHYRKYQKGE ETSTNSIASI FAWSRGLLKR 360
  361 GELDNTPALC KFANILESAT LNTVQQDGIM TKDLALACGN NERSAYVTTE EFLDAVEKRL 420
  421 QKEIKSIE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 158.228787
Match: 1a05A_
Description: 3-isopropylmalate dehydrogenase, IPMDH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
isocitrate dehydrogenase (NAD+) activity 5.9567768649084 bayes_pls_golite062009
isocitrate dehydrogenase activity 5.76817846591752 bayes_pls_golite062009
isocitrate dehydrogenase (NADP+) activity 3.47645456015586 bayes_pls_golite062009
oxidoreductase activity 2.74237430402883 bayes_pls_golite062009
catalytic activity 2.71251959637136 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 2.46799258909805 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2.38235863668553 bayes_pls_golite062009
transferase activity, transferring acyl groups 1.15484868227001 bayes_pls_golite062009
3-isopropylmalate dehydrogenase activity 0.848289435089509 bayes_pls_golite062009
binding 0.530580225668688 bayes_pls_golite062009
protein binding 0.074256700284446 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle