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View Structure Prediction Details

Protein: PRP11
Organism: Saccharomyces cerevisiae
Length: 266 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRP11.

Description E-value Query
Range
Subject
Range
gi|207346926 - gi|207346926|gb|EDZ73270.1| YDL043Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190405053 - gi|190405053|gb|EDV08320.1| snRNA-associated protein [Saccharomyces cerevisiae RM11-1a]
PRP11 - Subunit of the SF3a splicing factor complex, required for spliceosome assembly
PRP11_YEAST - Pre-mRNA-splicing factor PRP11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRP11 PE=...
2.0E-97 [1..266] [1..266]
CG10754-PA - This gene is referred to in FlyBase by the symbol Dmel\CG10754 (CG10754, FBgn0036314). It is a prote...
gi|220944472, gi... - gi|220954270|gb|ACL89678.1| CG10754-PA [synthetic construct], gi|220944472|gb|ACL84779.1| CG10754-PA...
1.0E-86 [1..257] [1..214]
SF3A2_MOUSE - Splicing factor 3A subunit 2 OS=Mus musculus GN=Sf3a2 PE=1 SV=2
2.0E-84 [1..261] [1..217]
CE28910 - status:Confirmed UniProt:Q19335 protein_id:CAA92593.2
3.0E-84 [1..260] [1..215]
sap62 - zinc finger protein Sap62
SAP62_SCHPO - Pre-mRNA-splicing factor sap62 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sap62 PE=1 ...
3.0E-77 [1..260] [1..215]
gi|15450715, gi|... - gi|20466089|gb|AAM19966.1| At2g32600/T26B15.16 [Arabidopsis thaliana], gi|20197236|gb|AAC25942.2| pu...
2.0E-69 [8..262] [6..216]

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Predicted Domain #1
Region A:
Residues: [1-121]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNYLEGVGSK KGGGGIASES QFNLQRRKEV ESLLSKGENV PYTFQDEKDD QVRSNPYIYK  60
   61 NHSGKLVCKL CNTMHMSWSS VERHLGGKKH GLNVLRRGIS IEKSSLGREG QTTHDFRQQQ 120
  121 K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.37529385176635 bayes_pls_golite062009
DNA binding 3.3049326844117 bayes_pls_golite062009
nucleic acid binding 3.24981360535232 bayes_pls_golite062009
snRNA binding 3.16782731106334 bayes_pls_golite062009
RNA binding 3.11293528368816 bayes_pls_golite062009
U1 snRNA binding 2.86343975521155 bayes_pls_golite062009
binding 2.84954567129719 bayes_pls_golite062009
transcription factor activity 2.44389510173662 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.57041104288348 bayes_pls_golite062009
mRNA binding 1.28525296322454 bayes_pls_golite062009
transcription activator activity 1.20323819132961 bayes_pls_golite062009
protein binding 0.975412203442928 bayes_pls_golite062009
sequence-specific DNA binding 0.732558534458316 bayes_pls_golite062009
transcription repressor activity 0.686318575498149 bayes_pls_golite062009
chromatin binding 0.626365497850853 bayes_pls_golite062009
transcription factor binding 0.515821187939278 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.200483461579207 bayes_pls_golite062009
transcription cofactor activity 0.113925660147477 bayes_pls_golite062009
structure-specific DNA binding 0.0855506955761403 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [122-266]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IIEAKQSLKN NGTIPVCKIA TVKNPKNGSV GLAIQVNYSS EVKENSVDSD DKAKVPPLIR  60
   61 IVSGLELSDT KQKGKKFLVI AYEPFENIAI ELPPNEILFS ENNDMDNNND GVDELNKKCT 120
  121 FWDAISKLYY VQFFFKQAEQ EQADV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [225-266]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DMDNNNDGVD ELNKKCTFWD AISKLYYVQF FFKQAEQEQA DV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle