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View Structure Prediction Details

Protein: PRP11
Organism: Saccharomyces cerevisiae
Length: 266 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRP11.

Description E-value Query
Range
Subject
Range
gi|207346926 - gi|207346926|gb|EDZ73270.1| YDL043Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190405053 - gi|190405053|gb|EDV08320.1| snRNA-associated protein [Saccharomyces cerevisiae RM11-1a]
PRP11 - Subunit of the SF3a splicing factor complex, required for spliceosome assembly
PRP11_YEAST - Pre-mRNA-splicing factor PRP11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRP11 PE=...
2.0E-97 [1..266] [1..266]
CG10754-PA - This gene is referred to in FlyBase by the symbol Dmel\CG10754 (CG10754, FBgn0036314). It is a prote...
gi|220944472, gi... - gi|220954270|gb|ACL89678.1| CG10754-PA [synthetic construct], gi|220944472|gb|ACL84779.1| CG10754-PA...
1.0E-86 [1..257] [1..214]
SF3A2_MOUSE - Splicing factor 3A subunit 2 OS=Mus musculus GN=Sf3a2 PE=1 SV=2
2.0E-84 [1..261] [1..217]
CE28910 - status:Confirmed UniProt:Q19335 protein_id:CAA92593.2
3.0E-84 [1..260] [1..215]
sap62 - zinc finger protein Sap62
SAP62_SCHPO - Pre-mRNA-splicing factor sap62 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sap62 PE=1 ...
3.0E-77 [1..260] [1..215]
gi|15450715, gi|... - gi|20466089|gb|AAM19966.1| At2g32600/T26B15.16 [Arabidopsis thaliana], gi|20197236|gb|AAC25942.2| pu...
2.0E-69 [8..262] [6..216]

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Predicted Domain #1
Region A:
Residues: [1-121]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNYLEGVGSK KGGGGIASES QFNLQRRKEV ESLLSKGENV PYTFQDEKDD QVRSNPYIYK  60
   61 NHSGKLVCKL CNTMHMSWSS VERHLGGKKH GLNVLRRGIS IEKSSLGREG QTTHDFRQQQ 120
  121 K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.242 d.110.4 SNARE-like
View Download 0.290 c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.213 a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.237 a.121.1 Tetracyclin repressor-like, C-terminal domain

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.37529385176635 bayes_pls_golite062009
DNA binding 3.3049326844117 bayes_pls_golite062009
nucleic acid binding 3.24981360535232 bayes_pls_golite062009
snRNA binding 3.16782731106334 bayes_pls_golite062009
RNA binding 3.11293528368816 bayes_pls_golite062009
U1 snRNA binding 2.86343975521155 bayes_pls_golite062009
binding 2.84954567129719 bayes_pls_golite062009
transcription factor activity 2.44389510173662 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.57041104288348 bayes_pls_golite062009
mRNA binding 1.28525296322454 bayes_pls_golite062009
transcription activator activity 1.20323819132961 bayes_pls_golite062009
protein binding 0.975412203442928 bayes_pls_golite062009
sequence-specific DNA binding 0.732558534458316 bayes_pls_golite062009
transcription repressor activity 0.686318575498149 bayes_pls_golite062009
chromatin binding 0.626365497850853 bayes_pls_golite062009
transcription factor binding 0.515821187939278 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.200483461579207 bayes_pls_golite062009
transcription cofactor activity 0.113925660147477 bayes_pls_golite062009
structure-specific DNA binding 0.0855506955761403 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [122-266]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IIEAKQSLKN NGTIPVCKIA TVKNPKNGSV GLAIQVNYSS EVKENSVDSD DKAKVPPLIR  60
   61 IVSGLELSDT KQKGKKFLVI AYEPFENIAI ELPPNEILFS ENNDMDNNND GVDELNKKCT 120
  121 FWDAISKLYY VQFFFKQAEQ EQADV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.375 0.273 U2 snRNP d.19.1 MHC antigen-recognition domain
View Download 0.476 0.066 U2 snRNP b.2.3 Bacterial adhesins
View Download 0.342 0.019 U2 snRNP c.97.1 Cytidine deaminase-like
View Download 0.458 0.013 U2 snRNP d.232.1 Mago nashi protein
View Download 0.379 0.005 U2 snRNP f.18.1 F1F0 ATP synthase subunit A
View Download 0.476 N/A N/A b.2.3 Bacterial adhesins
View Download 0.458 N/A N/A d.232.1 Mago nashi protein
View Download 0.379 N/A N/A f.18.1 F1F0 ATP synthase subunit A
View Download 0.375 N/A N/A d.19.1 MHC antigen-recognition domain
View Download 0.342 N/A N/A c.97.1 Cytidine deaminase-like
View Download 0.323 N/A N/A d.113.1 Nudix
View Download 0.304 N/A N/A a.24.11 Bacterial GAP domain
View Download 0.303 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.275 N/A N/A d.189.1 PX domain
View Download 0.274 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.263 N/A N/A c.78.1 Aspartate/ornithine carbamoyltransferase
View Download 0.262 N/A N/A d.150.1 4'-phosphopantetheinyl transferase
View Download 0.260 N/A N/A d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.258 N/A N/A d.104.1 Class II aaRS and biotin synthetases
View Download 0.255 N/A N/A d.54.1 Enolase N-terminal domain-like
View Download 0.246 N/A N/A d.153.1 N-terminal nucleophile aminohydrolases (Ntn hydrolases)
View Download 0.235 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.227 N/A N/A d.15.6 Superantigen toxins, C-terminal domain
View Download 0.222 N/A N/A d.15.5 Staphylokinase/streptokinase
View Download 0.220 N/A N/A c.55.3 Ribonuclease H-like
View Download 0.215 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.210 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain

Predicted Domain #3
Region A:
Residues: [225-266]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DMDNNNDGVD ELNKKCTFWD AISKLYYVQF FFKQAEQEQA DV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle