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View Structure Prediction Details

Protein: OCA4
Organism: Saccharomyces cerevisiae
Length: 362 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OCA4.

Description E-value Query
Range
Subject
Range
OCA4 - Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a mode...
gi|207347215 - gi|207347215|gb|EDZ73468.1| YCR095Cp-like protein [Saccharomyces cerevisiae AWRI1631]
OCA4_YEAST - Protein OCA4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OCA4 PE=1 SV=1
gi|190406511 - gi|190406511|gb|EDV09778.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
0.0 [1..362] [1..362]
gi|5815156 - gi|5815156|gb|AAD52574.1|AF170312_1 unknown protein [Saccharomyces kluyveri]
4.0E-51 [253..361] [4..108]
gi|15810022, gi|... - gi|26452426|dbj|BAC43298.1| unknown protein [Arabidopsis thaliana], gi|21555065|gb|AAM63767.1| conta...
7.0E-4 [134..203] [102..176]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.003 [134..204] [25..100]

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Predicted Domain #1
Region A:
Residues: [1-226]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLVPPANFGI AEEGIYRCSK VETLNLSFLE TLNLKTAIFI GGQEPSKFFK DFFTRSSIKW  60
   61 IVLRMSDFSA AAVPVKSSSV SNANLYSNNN STLSLQEEKK KSTANGSQNS TTGDPVIQEE 120
  121 LAYHLTDNDD LMLIKSTCLK RTFKTLLNVD NYNVLLVDKT ALVIGILRKI QKWNIASIIN 180
  181 EYRLFSGKNR NYFAETFLEI INIEIEQEKD NKTIVDNKAK KLPLEN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.43
Match: 1vhrA
Description: VH1-related dual-specificity phosphatase, VHR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 0.358519802008252 bayes_pls_golite062009
phosphatase activity 0.298546457607955 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.286217525019196 bayes_pls_golite062009
catalytic activity 0.231822394832085 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.200316594632455 bayes_pls_golite062009
phosphoprotein phosphatase activity 0.121593189497382 bayes_pls_golite062009
binding 0.0364808517837579 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [227-362]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRTHSIEYKA NSGKLIRVNE DDLCREPEVP QRLLTLINQI ETKVKNNKVL QVSGVLGDDL  60
   61 KKTSSDLGIF GHRYRLAFNK KENGDYGYYK ARGKDNVKIR IPCDSELPDW FRFQRDLWEK 120
  121 ENVPEEHHFY REHIFT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.592 0.257 cytoplasm a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.494 0.246 cytoplasm d.169.1 C-type lectin-like
View Download 0.567 0.245 cytoplasm a.118.8 TPR-like
View Download 0.529 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.494 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.419 N/A N/A d.150.1 4'-phosphopantetheinyl transferase
View Download 0.417 N/A N/A a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.404 N/A N/A a.63.1 Apolipophorin-III
View Download 0.404 N/A N/A d.110.1 Profilin (actin-binding protein)
View Download 0.381 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.363 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.355 N/A N/A d.91.1 N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
View Download 0.351 N/A N/A a.24.4 Hemerythrin
View Download 0.340 N/A N/A a.47.2 t-snare proteins
View Download 0.333 N/A N/A d.150.1 4'-phosphopantetheinyl transferase
View Download 0.326 N/A N/A a.91.1 Regulator of G-protein signalling, RGS
View Download 0.325 N/A N/A a.118.8 TPR-like
View Download 0.320 N/A N/A a.118.8 TPR-like
View Download 0.318 N/A N/A c.23.5 Flavoproteins
View Download 0.292 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.288 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.280 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.272 N/A N/A a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.268 N/A N/A d.163.1 DNA breaking-rejoining enzymes
View Download 0.264 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.262 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.260 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.256 N/A N/A d.79.3 L30e-like
View Download 0.255 N/A N/A a.25.1 Ferritin-like
View Download 0.251 N/A N/A a.26.1 4-helical cytokines
View Download 0.250 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.238 N/A N/A a.126.1 Serum albumin-like
View Download 0.235 N/A N/A a.126.1 Serum albumin-like
View Download 0.230 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.229 N/A N/A a.24.3 Cytochromes
View Download 0.223 N/A N/A a.2.3 Chaperone J-domain
View Download 0.219 N/A N/A d.58.46 eEF1-gamma domain
View Download 0.216 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.212 N/A N/A a.4.12 TrpR-like
View Download 0.206 N/A N/A c.47.1 Thioredoxin-like
View Download 0.204 N/A N/A a.25.1 Ferritin-like
View Download 0.201 N/A N/A a.1.1 Globin-like

Predicted Domain #3
Region A:
Residues: [217-362]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKAKKLPLEN NRTHSIEYKA NSGKLIRVNE DDLCREPEVP QRLLTLINQI ETKVKNNKVL  60
   61 QVSGVLGDDL KKTSSDLGIF GHRYRLAFNK KENGDYGYYK ARGKDNVKIR IPCDSELPDW 120
  121 FRFQRDLWEK ENVPEEHHFY REHIFT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.592 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.567 N/A N/A a.118.8 TPR-like
View Download 0.529 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.494 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.494 N/A N/A d.169.1 C-type lectin-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle