YRC Public Data Repository - Protein Structure Prediction

Protein:	SSK22
Organism:	Saccharomyces cerevisiae
Length:	1331 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SSK22.

Description	E-value	Query Range	Subject Range
SSK2_YEAST - MAP kinase kinase kinase SSK2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SSK2 PE=1 ... SSK2 - MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, lead...	1611.0	[0..24]	[1318..217]
gi\|44983909, gi\|... - gi\|45190867\|ref\|NP_985121.1\| AER264Cp [Ashbya gossypii ATCC 10895], gi\|44983909\|gb\|AAS52945.1\| AER26... gi\|44983909 - gi\|44983909\|gb\|AAS52945.1\| AER264Cp [Ashbya gossypii ATCC 10895]	1076.0	[0..62]	[1324..170]
gi\|49641713 - gi\|49641713\|emb\|CAH01431.1\| KLLA0C08525p [Kluyveromyces lactis] gi\|49641713, gi\|... - gi\|50305241\|ref\|XP_452580.1\| unnamed protein product [Kluyveromyces lactis], gi\|49641713\|emb\|CAH0143...	1030.0	[0..34]	[1318..210]
gi\|49653730, gi\|... - gi\|50419083\|ref\|XP_458064.1\| hypothetical protein DEHA0C09823g [Debaryomyces hansenii CBS767], gi\|49...	921.0	[0..5]	[1318..98]
gi\|68477261, gi\|... - gi\|68477261\|ref\|XP_717257.1\| likely protein kinase [Candida albicans SC5314], gi\|46438961\|gb\|EAK9828... orf19.11257 - SSK2 CGDID:CAL0001272 Assembly 19, Contig19-20192 (13812, 18266) CDS, translated using codon table 1...	900.0	[0..68]	[1330..205]
gi\|27529700 - gi\|27529700\|dbj\|BAA13204.2\| KIAA0213 [Homo sapiens]	812.0	[0..359]	[1311..657]
gi\|73945781 - gi\|73945781\|ref\|XP_862916.1\| PREDICTED: similar to mitogen-activated protein kinase kinase kinase 4 ...	802.0	[0..359]	[1311..590]
gi\|109460760 - gi\|109460760\|ref\|XP_001063095.1\| PREDICTED: similar to mitogen activated protein kinase kinase kinas...	758.0	[0..359]	[1311..580]

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Predicted Domain #1

Region A:
Residues: [1-103]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMMDILNTQQ QKAAEGGRVL APHTISSKLV KRLSSHSSHK LSRSDLKALG GSETISDGPS  60
   61 QLTFKDRYVF NESLYLKKLK KTALDDYYTR GIKLTNRYEE DDG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [104-267]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDEIIRLSNG DRIDEDLHSG VKFFSTTPYC RKMRSDSDEL AWNEIATERF KWQSMLARVL  60
   61 KGDIVKGEKT RIANQVKKPG LNKELSDEIW LELKAWLNGR TMQEMEQSLT YLRDSSDSVF 120
  121 EEIMKFQIPQ GKILSLDALE AILQDLMNRY HSVVSYWPNL KKMY

[Run NCBI BLAST on this sequence.]

Detection Method:	ab initio
Confidence:	11.29
Match:
Description:	No description for 1hciA was found.

Predicted Domain #3

Region A:
Residues: [268-378]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDKPITNTAE FTARIDVMNS WLNFKTNLTL RRQELDDWIN RFSPISSSDN CQEDFDGVPQ  60
   61 WNCKMKILAE QLMKEKNIES IFQKKIFYPL SPWMFKLKLH FIVYRETLTK M

[Run NCBI BLAST on this sequence.]

Detection Method:	ab initio
Confidence:	11.29
Match:
Description:	No description for 1hciA was found.

Predicted Domain #4

Region A:
Residues: [379-502]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIKYPYERLR SLLAFPVYLI KEVILTRLSY ARKLKNPTMM MIDQMIDDFN AFIRLSVQLK  60
   61 YTLTKYCSNL PFDVDFDPTF ENTVIEAIRY LFFLLNLKLI DSSKQNFKAP DLLLKYWDHL 120
  121 KNTG

[Run NCBI BLAST on this sequence.]

Detection Method:	ab initio
Confidence:	11.29
Match:
Description:	No description for 1hciA was found.

Predicted Domain #5

Region A:
Residues: [503-641]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HYINGAETVI PNEFLKLTLR LVHKLQFYLL KQQNFPPTFA NASEAEKWLS SIFENLGAMK  60
   61 RKLNRFSNIL VKAFQNSAVY QINHNAQLVK KLKDAHYFLV YSGNTFESSG VYMFAAPELL 120
  121 GCDNDTILRI LRNKSIGCD

[Run NCBI BLAST on this sequence.]

Detection Method:	ab initio
Confidence:	11.29
Match:
Description:	No description for 1hciA was found.

Predicted Domain #6

Region A:
Residues: [642-842]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVPKLDIGNN LNVYDITTKE TDLNILVSKG EDSKGIPYYR VVANSSSDLD RHAHQSKKKN  60
   61 FSTDPFDQHL DEKNNEVFEL EVALSSLGAL VVLYPGEPVV WDGPVYKLPG NNLFASNEMD 120
  121 LGKIGNPNTL ILLNQGSNYA LTYQIDKFNQ TVGDSVSFIE KRCSLNSIES SLQKINKAYY 180
  181 KLTYTVLNNY KGILGSFMKQ C

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [843-942]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGNELLNSIF MFGRDFGRSF LKYNAFSSKR KYVIIFLMVK LGMNWLKFLV EECDPTDQRT  60
   61 FRWCVLAMDF AMQMTSGYNI LALNVKQFQE LKERVSVCMS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	3.522879
Match:	1f3mA
Description:	pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #8

Region A:
Residues: [943-999]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLISHFDVMG ARATEAENGM QQARLNIDTE ENIDEEATLE INSRLRLEAI KTLEKTM

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9

Region A:
Residues: [1000-1114]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRNPRQMGKV LDATDQGNKY LLSLASSLSN VSMRWQKRSF IGGGTFGQVY SAINLENGEI  60
   61 LAVKEIKIHD TTTMKKIFPL IKEEMTVLEM LNHPNIVQYY GVEVHRDKVN IFMEY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	429.218487
Match:	1f3mC
Description:	pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #10

Region A:
Residues: [1115-1331]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CEGGSLASLL DHGRIEDEMV TQVYTFELLE GLAYLHQSGV VHRDIKPENI LLDFNGIIKY  60
   61 VDFGTARTVV GSRTRTVRNA AVQDFGVETK SLNEMMGTPM YMAPETISGS AVKGKLGADD 120
  121 VWALGCVVLE MATGRRPWSN LDNEWAIMYH VAAGRIPQLP NRDEMTAAGR AFLERCLVQD 180
  181 PTMRATAVEL LIDPWMIQIR EIAFGNSEKD QVPILSS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	429.218487
Match:	1f3mC
Description:	pak1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits