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View Structure Prediction Details

Protein: SSK22
Organism: Saccharomyces cerevisiae
Length: 1331 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SSK22.

Description E-value Query
Range
Subject
Range
SSK2_YEAST - MAP kinase kinase kinase SSK2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SSK2 PE=1 ...
SSK2 - MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, lead...
1611.0 [0..24] [1318..217]
gi|44983909, gi|... - gi|45190867|ref|NP_985121.1| AER264Cp [Ashbya gossypii ATCC 10895], gi|44983909|gb|AAS52945.1| AER26...
gi|44983909 - gi|44983909|gb|AAS52945.1| AER264Cp [Ashbya gossypii ATCC 10895]
1076.0 [0..62] [1324..170]
gi|49641713 - gi|49641713|emb|CAH01431.1| KLLA0C08525p [Kluyveromyces lactis]
gi|49641713, gi|... - gi|50305241|ref|XP_452580.1| unnamed protein product [Kluyveromyces lactis], gi|49641713|emb|CAH0143...
1030.0 [0..34] [1318..210]
gi|49653730, gi|... - gi|50419083|ref|XP_458064.1| hypothetical protein DEHA0C09823g [Debaryomyces hansenii CBS767], gi|49...
921.0 [0..5] [1318..98]
gi|68477261, gi|... - gi|68477261|ref|XP_717257.1| likely protein kinase [Candida albicans SC5314], gi|46438961|gb|EAK9828...
orf19.11257 - SSK2 CGDID:CAL0001272 Assembly 19, Contig19-20192 (13812, 18266) CDS, translated using codon table 1...
900.0 [0..68] [1330..205]
gi|27529700 - gi|27529700|dbj|BAA13204.2| KIAA0213 [Homo sapiens]
812.0 [0..359] [1311..657]
gi|73945781 - gi|73945781|ref|XP_862916.1| PREDICTED: similar to mitogen-activated protein kinase kinase kinase 4 ...
802.0 [0..359] [1311..590]
gi|109460760 - gi|109460760|ref|XP_001063095.1| PREDICTED: similar to mitogen activated protein kinase kinase kinas...
758.0 [0..359] [1311..580]

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Predicted Domain #1
Region A:
Residues: [1-103]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMMDILNTQQ QKAAEGGRVL APHTISSKLV KRLSSHSSHK LSRSDLKALG GSETISDGPS  60
   61 QLTFKDRYVF NESLYLKKLK KTALDDYYTR GIKLTNRYEE DDG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.324 a.158.1 F-box domain
View Download 0.324 a.158.1 F-box domain
View Download 0.315 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.262 a.24.17 Group V grass pollen allergen
View Download 0.262 a.24.17 Group V grass pollen allergen
View Download 0.250 a.40.1 Calponin-homology domain, CH-domain
View Download 0.240 d.68.6 DNA-binding protein Sso10b (AlbA)
View Download 0.236 a.76.1 Iron-dependent represor protein, dimerization domain

Predicted Domain #2
Region A:
Residues: [104-267]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDEIIRLSNG DRIDEDLHSG VKFFSTTPYC RKMRSDSDEL AWNEIATERF KWQSMLARVL  60
   61 KGDIVKGEKT RIANQVKKPG LNKELSDEIW LELKAWLNGR TMQEMEQSLT YLRDSSDSVF 120
  121 EEIMKFQIPQ GKILSLDALE AILQDLMNRY HSVVSYWPNL KKMY

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 11.29
Match:
Description: No description for 1hciA was found.

Predicted Domain #3
Region A:
Residues: [268-378]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDKPITNTAE FTARIDVMNS WLNFKTNLTL RRQELDDWIN RFSPISSSDN CQEDFDGVPQ  60
   61 WNCKMKILAE QLMKEKNIES IFQKKIFYPL SPWMFKLKLH FIVYRETLTK M

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 11.29
Match:
Description: No description for 1hciA was found.

Predicted Domain #4
Region A:
Residues: [379-502]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIKYPYERLR SLLAFPVYLI KEVILTRLSY ARKLKNPTMM MIDQMIDDFN AFIRLSVQLK  60
   61 YTLTKYCSNL PFDVDFDPTF ENTVIEAIRY LFFLLNLKLI DSSKQNFKAP DLLLKYWDHL 120
  121 KNTG

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 11.29
Match:
Description: No description for 1hciA was found.

Predicted Domain #5
Region A:
Residues: [503-641]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HYINGAETVI PNEFLKLTLR LVHKLQFYLL KQQNFPPTFA NASEAEKWLS SIFENLGAMK  60
   61 RKLNRFSNIL VKAFQNSAVY QINHNAQLVK KLKDAHYFLV YSGNTFESSG VYMFAAPELL 120
  121 GCDNDTILRI LRNKSIGCD

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 11.29
Match:
Description: No description for 1hciA was found.

Predicted Domain #6
Region A:
Residues: [642-842]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVPKLDIGNN LNVYDITTKE TDLNILVSKG EDSKGIPYYR VVANSSSDLD RHAHQSKKKN  60
   61 FSTDPFDQHL DEKNNEVFEL EVALSSLGAL VVLYPGEPVV WDGPVYKLPG NNLFASNEMD 120
  121 LGKIGNPNTL ILLNQGSNYA LTYQIDKFNQ TVGDSVSFIE KRCSLNSIES SLQKINKAYY 180
  181 KLTYTVLNNY KGILGSFMKQ C

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [843-942]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGNELLNSIF MFGRDFGRSF LKYNAFSSKR KYVIIFLMVK LGMNWLKFLV EECDPTDQRT  60
   61 FRWCVLAMDF AMQMTSGYNI LALNVKQFQE LKERVSVCMS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 1f3mA
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [943-999]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLISHFDVMG ARATEAENGM QQARLNIDTE ENIDEEATLE INSRLRLEAI KTLEKTM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.539 a.23.7 Description not found.
View Download 0.439 a.4.1 Homeodomain-like
View Download 0.439 a.4.1 Homeodomain-like
View Download 0.414 a.4.1 Homeodomain-like
View Download 0.414 a.4.1 Homeodomain-like
View Download 0.413 a.34.4 Description not found.
View Download 0.410 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.356 a.64.1 Saposin
View Download 0.345 a.4.5 "Winged helix" DNA-binding domain
View Download 0.309 a.180.1 N-terminal, cytoplasmic domain of anti-sigmaE factor RseA

Predicted Domain #9
Region A:
Residues: [1000-1114]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRNPRQMGKV LDATDQGNKY LLSLASSLSN VSMRWQKRSF IGGGTFGQVY SAINLENGEI  60
   61 LAVKEIKIHD TTTMKKIFPL IKEEMTVLEM LNHPNIVQYY GVEVHRDKVN IFMEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 429.218487
Match: 1f3mC
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #10
Region A:
Residues: [1115-1331]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CEGGSLASLL DHGRIEDEMV TQVYTFELLE GLAYLHQSGV VHRDIKPENI LLDFNGIIKY  60
   61 VDFGTARTVV GSRTRTVRNA AVQDFGVETK SLNEMMGTPM YMAPETISGS AVKGKLGADD 120
  121 VWALGCVVLE MATGRRPWSN LDNEWAIMYH VAAGRIPQLP NRDEMTAAGR AFLERCLVQD 180
  181 PTMRATAVEL LIDPWMIQIR EIAFGNSEKD QVPILSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 429.218487
Match: 1f3mC
Description: pak1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle