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View Structure Prediction Details

Protein: PGK1
Organism: Saccharomyces cerevisiae
Length: 416 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PGK1.

Description E-value Query
Range		 Subject
Range
PGK1_PANTR - Phosphoglycerate kinase 1 OS=Pan troglodytes GN=PGK1 PE=2 SV=1
PGK1 - phosphoglycerate kinase 1
gi|146741442 - gi|146741442|dbj|BAF62377.1| phosphoglycerate kinase 1 [Pan troglodytes verus]
gi|168279045 - gi|168279045|dbj|BAG11402.1| phosphoglycerate kinase 1 [synthetic construct]
 0.0 [1..414] [1..416]
PGK1_MACEU - Phosphoglycerate kinase 1 OS=Macropus eugenii GN=PGK1 PE=2 SV=2
 0.0 [1..414] [1..416]
PGK1_CRIGR - Phosphoglycerate kinase 1 OS=Cricetulus griseus GN=PGK1 PE=2 SV=2
 0.0 [1..414] [1..416]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [2..414] [1..415]
PGK_CHICK - Phosphoglycerate kinase OS=Gallus gallus GN=PGK PE=2 SV=2
 0.0 [1..413] [1..415]
PGK1_HORSE - Phosphoglycerate kinase 1 OS=Equus caballus GN=PGK1 PE=1 SV=2
 0.0 [2..414] [1..415]
PGK_SCHMA - Phosphoglycerate kinase OS=Schistosoma mansoni GN=PGK PE=1 SV=1
 0.0 [1..414] [1..414]
PGK2_MOUSE - Phosphoglycerate kinase 2 OS=Mus musculus GN=Pgk2 PE=1 SV=3
 0.0 [1..414] [1..416]

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Predicted Domain #1
Region A:
Residues: [1-190] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSSKLSVQ DLDLKDKRVF IRVDFNVPLD GKKITSNQRI VAALPTIKYV LEHHPRYVVL  60
   61 ASHLGRPNGE RNEKYSLAPV AKELQSLLGK DVTFLNDCVG PEVEAAVKAS APGSVILLEN 120
  121 LRYHIEEEGS RKVDGQKVKA SKEDVQKFRH ELSSLADVYI NDAFGTAHRA HSSMVGFDLP 180
  181 QRAAGFLLEK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [406-416] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPGVAFLSEK K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1qpg__
Description: Phosphoglycerate kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphoglycerate kinase activity 5.4060222740811 bayes_pls_golite062009
kinase activity 5.10875323814482 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.75644406547116 bayes_pls_golite062009
transferase activity 3.84971620558441 bayes_pls_golite062009
catalytic activity 2.30057758519011 bayes_pls_golite062009
phosphotransferase activity, carboxyl group as acceptor 2.28472985705972 bayes_pls_golite062009
binding 2.00400587462181 bayes_pls_golite062009
ATP binding 1.2270597395465 bayes_pls_golite062009
adenyl ribonucleotide binding 1.19223643201287 bayes_pls_golite062009
adenyl nucleotide binding 1.17740080861612 bayes_pls_golite062009
transcription regulator activity 0.9898248694651 bayes_pls_golite062009
ribonucleotide binding 0.946046256290779 bayes_pls_golite062009
purine ribonucleotide binding 0.943434082819351 bayes_pls_golite062009
purine nucleotide binding 0.936146648259702 bayes_pls_golite062009
nucleotide binding 0.931721122227797 bayes_pls_golite062009
protein binding 0.206093694938779 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [191-405] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELKYFGKALE NPTRPFLAIL GGAKVADKIQ LIDNLLDKVD SIIIGGGMAF TFKKVLENTE  60
   61 IGDSIFDKAG AEIVPKLMEK AKAKGVEVVL PVDFIIADAF SADANTKTVT DKEGIPAGWQ 120
  121 GLDNGPESRK LFAATVAKAK TIVWNGPPGV FEFEKFAAGT KALLDEVVKS SAAGNTVIIG 180
  181 GGDTATVAKK YGVTDKISHV STGGGASLEL LEGKE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1qpg__
Description: Phosphoglycerate kinase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle