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View Structure Prediction Details

Protein: APA1
Organism: Saccharomyces cerevisiae
Length: 321 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APA1.

Description E-value Query
Range
Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..321] [1..321]
APA1_YEAST - Protein APA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=APA1 PE=1 SV=4
gi|207347386 - gi|207347386|gb|EDZ73576.1| YCL050Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190406398 - gi|190406398|gb|EDV09665.1| diadenosine 5',5'-P1,P4-tetraphosphate phosphorylase I [Saccharomyces ce...
APA1 - Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism...
gi|151943783 - gi|151943783|gb|EDN62083.1| diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase I [Saccharomyces ...
0.0 [1..321] [1..321]
APA2_KLULA - 5',5'''-P-1,P-4-tetraphosphate phosphorylase 2 OS=Kluyveromyces lactis GN=APA2 PE=3 SV=1
APA2_KLULA - Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2 OS=Kluyveromyces lactis (strain ATCC 8585 /...
0.0 [4..321] [3..331]
gi|17133602, gi|... - gi|17231958|ref|NP_488506.1| Ap4A phosphorylase II [Nostoc sp. PCC 7120], gi|17133602|dbj|BAB76165.1...
gi|25530194 - pir||AB2364 Ap4A phosphorylase II [imported] - Nostoc sp. (strain PCC 7120)
2.0E-65 [4..294] [12..289]
gi|7469381 - pir||S75978 hypothetical protein - Synechocystis sp. (strain PCC 6803)
gi|16332026, gi|... - gi|16332026|ref|NP_442754.1| AP-4-A phosphorylase II [Synechocystis sp. PCC 6803], gi|1001338|dbj|BA...
2.0E-56 [91..285] [108..279]
gi|5458401, gi|7... - pir||D75073 hit-like protein PAB0657 - Pyrococcus abyssi (strain Orsay), gi|5458401|emb|CAB49889.1| ...
gi|5458401, gi|1... - gi|5458401|emb|CAB49889.1| Histidine triad (HIT) protein [Pyrococcus abyssi GE5], gi|14521183|ref|NP...
0.005 [64..163] [2..99]
AGLUP_ARATH - ADP-glucose phosphorylase OS=Arabidopsis thaliana GN=At5g18200 PE=1 SV=1
0.008 [114..185] [141..213]

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Predicted Domain #1
Region A:
Residues: [1-185]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIPADIASL ISDKYKSAFD NGNLKFIQTE TTKTKDPKTS MPYLISHMPS LIEKPERGQT  60
   61 PEGEDPLGKP EEELTVIPEF GGADNKAYKL LLNKFPVIPE HTLLVTNEYQ HQTDALTPTD 120
  121 LLTAYKLLCA LDNEESDKRH MVFYNSGPAS GSSLDHKHLQ ILQMPEKFVT FQDRLCNGKE 180
  181 HFLPT

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.22
Match: 1gupA
Description: Galactose-1-phosphate uridylyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 1.74990165024183 bayes_pls_golite062009
binding 1.71599870633602 bayes_pls_golite062009
hydrolase activity 0.690968602046843 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.342529552808262 bayes_pls_golite062009
protein binding 0.315946879872005 bayes_pls_golite062009
catalytic activity 0.096119422680995 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [186-321]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNTEPLQDAK VSFAHFVLPM PESEETVDED LLAMCYISIL QRALTFFQDW LNENPELKKS  60
   61 YNLMLTKEWI CVVPRSKAFS DEMKIGFNST GYCGMILTKN DEVFSKITEK PELINDILLE 120
  121 CGFPNTSGQK PNEYNY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.382 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.542 d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.382 a.74.1 Cyclin-like
View Download 0.367 f.14.1 Voltage-gated potassium channels
View Download 0.373 a.71.2 Helical domain of Sec23/24
View Download 0.353 d.110.4 SNARE-like
View Download 0.349 a.24.9 alpha-catenin/vinculin
View Download 0.347 d.89.1 Origin of replication-binding domain, RBD-like
View Download 0.346 a.24.3 Cytochromes
View Download 0.333 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.331 d.202.1 Transcription factor NusA, N-terminal domain
View Download 0.323 d.218.1 Nucleotidyltransferase
View Download 0.317 d.130.1 S-adenosylmethionine synthetase
View Download 0.304 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.295 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.294 a.1.1 Globin-like
View Download 0.286 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.280 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.266 d.185.1 LuxS/MPP-like metallohydrolase
View Download 0.262 a.118.1 ARM repeat
View Download 0.261 a.71.2 Helical domain of Sec23/24
View Download 0.259 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.247 a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.242 a.25.1 Ferritin-like
View Download 0.237 d.6.1 Prion-like
View Download 0.235 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.235 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.230 d.19.1 MHC antigen-recognition domain
View Download 0.226 d.58.4 Dimeric alpha+beta barrel
View Download 0.221 a.39.1 EF-hand
View Download 0.219 a.55.1 IHF-like DNA-binding proteins
View Download 0.214 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle