YRC Public Data Repository - Protein Structure Prediction

Protein:	ATG22
Organism:	Saccharomyces cerevisiae
Length:	528 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATG22.

Description	E-value	Query Range	Subject Range
ATG22 - Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdo... ATG22_YEAST - Autophagy-related protein 22 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATG22 PE=1 ...	0.0	[1..528]	[1..528]
gi\|25499012 - pir\|\|E97095 MDR-type permease [imported] - Clostridium acetobutylicum gi\|15894863, gi\|... - gi\|15894863\|ref\|NP_348212.1\| MDR-type permease [Clostridium acetobutylicum ATCC 824], gi\|15024539\|gb...	2.0E-76	[19..519]	[2..425]
gi\|15616629 - gi\|15616629\|ref\|NP_243797.1\| major facilitator superfamily permease [Bacillus halodurans C-125]	2.0E-72	[20..515]	[3..420]
gi\|225628370, gi... - gi\|225628370\|ref\|ZP_03786404.1\| transporter [Brucella ceti str. Cudo], gi\|225616216\|gb\|EEH13264.1\| t... gi\|17982120, gi\|... - gi\|17986516\|ref\|NP_539150.1\| transporter [Brucella melitensis 16M], gi\|17982120\|gb\|AAL51414.1\| trans... gi\|25525296 - pir\|\|AC3281 transporter BMEI0232 [imported] - Brucella melitensis (strain 16M)	2.0E-71	[2..510]	[15..479]
YXIO_BACSU - Uncharacterized MFS-type transporter yxiO OS=Bacillus subtilis GN=yxiO PE=3 SV=1 gi\|221316206 - gi\|221316206\|ref\|ZP_03598011.1\| hypothetical protein BsubsN3_21017 [Bacillus subtilis subsp. subtili... gi\|221321118 - gi\|221321118\|ref\|ZP_03602412.1\| hypothetical protein BsubsJ_20965 [Bacillus subtilis subsp. subtilis... gi\|221325402 - gi\|221325402\|ref\|ZP_03606696.1\| hypothetical protein BsubsS_21116 [Bacillus subtilis subsp. subtilis... YXIO_BACSU - Uncharacterized MFS-type transporter YxiO OS=Bacillus subtilis (strain 168) GN=yxiO PE=3 SV=1	1.0E-67	[14..508]	[1..415]
gi\|25516920, gi\|... - pir\|\|AG1614 B. subtilis YxiO protein homolog lin1456 [imported] - Listeria innocua (strain Clip11262... gi\|16800524 - gi\|16800524\|ref\|NP_470792.1\| hypothetical protein lin1456 [Listeria innocua Clip11262]	3.0E-67	[20..507]	[2..409]
gi\|254827705, gi... - gi\|254827705\|ref\|ZP_05232392.1\| hypothetical protein LmonocytogeFSL_04535 [Listeria monocytogenes FS... gi\|224501641 - gi\|224501641\|ref\|ZP_03669948.1\| hypothetical protein LmonFR_03842 [Listeria monocytogenes FSL R2-561... gi\|224499728 - gi\|224499728\|ref\|ZP_03668077.1\| hypothetical protein LmonF1_08569 [Listeria monocytogenes Finland 19... gi\|16803457 - gi\|16803457\|ref\|NP_464942.1\| hypothetical protein lmo1417 [Listeria monocytogenes EGD-e] gi\|25517629, gi\|... - pir\|\|AI1251 B. subtilis YxiO protein homolog lmo1417 [imported] - Listeria monocytogenes (strain EGD... gi\|255027080 - gi\|255027080\|ref\|ZP_05299066.1\| hypothetical protein LmonocytFSL_13458 [Listeria monocytogenes FSL J...	2.0E-66	[20..507]	[2..409]
gi\|15076347 - gi\|15076347\|emb\|CAC47900.1\| MFS-type transport protein [Sinorhizobium meliloti 1021] gi\|15967074 - gi\|15967074\|ref\|NP_387427.1\| putative transmembrane protein [Sinorhizobium meliloti 1021]	5.0E-63	[14..511]	[8..462]
gi\|14024237, gi\|... - gi\|14024237\|dbj\|BAB50841.1\| mll4103 [Mesorhizobium loti MAFF303099], gi\|13473488\|ref\|NP_105055.1\| hy...	6.0E-63	[13..513]	[1..458]

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Predicted Domain #1

Region A:
Residues: [1-194]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYGTINDMN ESVTNYRIKK AQNNIKGWYA YSFSSEPFVV SAVSTYIPLL LQQFASINGV  60
   61 KVHDHSIPCL SETGSDSDKC VLGLFNNRIF VDTSSFALYV FSLSVLFQTI IVISVSGIVD 120
  121 LWGSVKFKGR ILVWFGIVGA LSTVAISKLN DTQIYSLAGL YIVANGCFGV INVVGNSLLP 180
  181 IFVKDSLKCQ SQGA

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [195-283]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YEPDKVDSLT TVISGRGASL GYSSALIVQI VSMFLVASKK GSKQDVQVAV LFVGIWWFVW  60
   61 QLPMIWLIDD VTIPIRVDDS TLASARSPY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.15783210522667	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
binding	1.01584233411372	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [284-528]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGEQDALGQL NWKNYLSYGW VSLFESFKHA RLLKDVMIFL IAWFIISDSI TTINSTAVLF  60
   61 SKAELHMSTL NLIMISVLTV VNAMLGAFMI PQFLATKFRW TSSQTLMYII IWASFIPFYG 120
  121 ILGFFFNAFG LKHKFEMFLL AIWYGLSLGG LSAVSRSVFS LIVPPGKEST FFSMFSITDK 180
  181 GSSILGPFLV GLLTDKTHNI RYSFYFFFLL LMLSLPVLNC LDVKRGRREA EELSQVLPES 240
  241 ERRLD

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: