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View Structure Prediction Details

Protein: FES1
Organism: Saccharomyces cerevisiae
Length: 290 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FES1.

Description E-value Query
Range		 Subject
Range
gi|239923315 - gi|239923315|gb|ACS34961.1| karyopherin alpha 3 [Sus scrofa]
gi|119904523 - gi|119904523|ref|XP_612814.3| PREDICTED: similar to importin alpha Q2 [Bos taurus]
IMA4_MOUSE - Importin subunit alpha-4 OS=Mus musculus GN=Kpna3 PE=1 SV=1
gi|62339392, gi|... - gi|62339392|ref|NP_001014792.1| karyopherin (importin) alpha 3 [Rattus norvegicus], gi|59800326|gb|A...
 3.0E-57 [1..290] [73..350]
KPNA2 - karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
 3.0E-57 [2..289] [71..358]
gi|13752562 - gi|13752562|gb|AAK38727.1|AF369707_1 importin alpha 2 [Capsicum annuum]
 4.0E-57 [7..290] [84..353]
gi|85098694 - gi|85098694|ref|XP_960652.1| importin alpha subunit [Neurospora crassa OR74A]
gi|32412524, gi|... - gi|32412524|ref|XP_326742.1| probable importin alpha SRP1 [MIPS] [Neurospora crassa], gi|28922164|gb...
 8.0E-57 [12..290] [99..359]
gi|25314874, gi|... - gi|2959322|emb|CAA74966.1| Importin alpha-like protein [Arabidopsis thaliana], pir||T52101 probable ...
 2.0E-56 [10..290] [86..348]

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Predicted Domain #1
Region A:
Residues: [1-118] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKLLQWSIA NSQGDKEAMA RAGQPDPKLL QQLFGGGGPD DPTLMKESMA VIMNPEVDLE  60
   61 TKLVAFDNFE MLIENLDNAN NIENLKLWEP LLDVLVQTKD EELRAAALSI IGTAVQNN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.221849
Match: 1ejlI_
Description: Importin alpha
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural molecule activity 4.37969512292045 bayes_pls_golite062009
binding 2.04462323043166 bayes_pls_golite062009
RNA binding 1.98024495780436 bayes_pls_golite062009
nucleic acid binding 1.06432844184023 bayes_pls_golite062009
protein binding 1.04044934052933 bayes_pls_golite062009
translation initiation factor activity 0.83079633551839 bayes_pls_golite062009
translation regulator activity 0.82193201542158 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.803700928110921 bayes_pls_golite062009
hydrolase activity 0.29428275639657 bayes_pls_golite062009
mRNA binding 0.12130984199507 bayes_pls_golite062009
DNA binding 0.107262897598599 bayes_pls_golite062009
transcription regulator activity 0.0841881392856098 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [119-174] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDSQNNFMKY DNGLRSLIEI ASDKTKPLDV RTKAFYALSN LIRNHKDISE KFFKLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.221849
Match: 1ejlI_
Description: Importin alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [175-290] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLDCIAPVLS DNTAKPKLKM RAIALLTAYL SSVKIDENII SVLRKDGVIE STIECLSDES  60
   61 NLNIIDRVLS FLSHLISSGI KFNEQELHKL NEGYKHIEPL KDRLNEDDYL AVKYVL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.221849
Match: 1ejlI_
Description: Importin alpha
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle