YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: KAP104
Organism: Saccharomyces cerevisiae
Length: 918 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KAP104.

Description E-value Query
Range		 Subject
Range
gi|1622943 - gi|1622943|gb|AAB68948.1| MIP [Homo sapiens]
 0.0 [1..912] [1..876]
gi|3293344 - gi|3293344|gb|AAC25709.1| transportin; TRN [Xenopus laevis]
 0.0 [7..912] [1..871]
KAP104 - Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediate...
IMB2_YEAST - Importin subunit beta-2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KAP104 PE=1 SV=1
 0.0 [1..918] [1..918]
FBpp0305273, Trn... - The gene Transportin is referred to in FlyBase by the symbol Dmel\Trn (CG7398, FBgn0024921). It is a...
 0.0 [4..916] [2..879]
TNPO2_MOUSE - Transportin-2 OS=Mus musculus GN=Tnpo2 PE=1 SV=1
 0.0 [4..912] [2..873]
imb-2 - importin beta, nuclear transport factor status:Partially_confirmed UniProt:O62332 protein_id:CAB0558...
 0.0 [5..912] [3..869]
IMB2_SCHPO - Importin subunit beta-2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=kap104 PE=3 SV=1
kap104 - karyopherin Kap104
 0.0 [5..883] [6..869]

Back

Predicted Domain #1
Region A:
Residues: [1-96] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASTWKPAED YVLQLATLLQ NCMSPNPEIR NNAMEAMENF QLQPEFLNYL CYILIEGESD  60
   61 DVLKQHYSLQ DLQNNRATAG MLLKNSMLGG NNLIKS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
protein transporter activity 4.58709163830613 bayes_pls_golite062009
binding 3.0667965351474 bayes_pls_golite062009
protein transmembrane transporter activity 2.74547353635661 bayes_pls_golite062009
transporter activity 2.48700774379895 bayes_pls_golite062009
nucleic acid binding 2.34284977509828 bayes_pls_golite062009
substrate-specific transporter activity 2.26725422172281 bayes_pls_golite062009
nuclear localization sequence binding 1.91487015967262 bayes_pls_golite062009
transcription regulator activity 1.76231475025891 bayes_pls_golite062009
protein binding 1.73688475473996 bayes_pls_golite062009
DNA binding 1.62032607987786 bayes_pls_golite062009
nuclear export signal receptor activity 1.29390474721722 bayes_pls_golite062009
transmembrane transporter activity 1.28481004323799 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.09652988954158 bayes_pls_golite062009
transcription factor activity 0.923253759652909 bayes_pls_golite062009
structural molecule activity 0.908029258648777 bayes_pls_golite062009
translation initiation factor activity 0.83079633551839 bayes_pls_golite062009
translation regulator activity 0.82193201542158 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.803700928110921 bayes_pls_golite062009
molecular transducer activity 0.662662274021266 bayes_pls_golite062009
signal transducer activity 0.662662274021266 bayes_pls_golite062009
signal sequence binding 0.57106697498903 bayes_pls_golite062009
mRNA binding 0.46864854653143 bayes_pls_golite062009
RNA binding 0.40024158562931 bayes_pls_golite062009
clathrin binding 0.35775052108553 bayes_pls_golite062009
active transmembrane transporter activity 0.252495966234234 bayes_pls_golite062009
ion transmembrane transporter activity 0.248585912061178 bayes_pls_golite062009
primary active transmembrane transporter activity 0.226380819487924 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.217517113570989 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.178770060806735 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.175241020572885 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.174922130116569 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.100181463251306 bayes_pls_golite062009
pyrophosphatase activity 0.0635404099346928 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0548082069333885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.052195223119721 bayes_pls_golite062009
cation transmembrane transporter activity 0.0405268469927988 bayes_pls_golite062009
transcription activator activity 0.0232727461674547 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [97-688] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSHDLGYVKS NIIHGLYNSN NNLVSNVTGI VITTLFSTYY RQHRDDPTGL QMLYQLLELT  60
   61 SNGNEPSIKA LSKIMEDSAQ FFQLEWSGNT KPMEALLDSF FRFISNPNFS PVIRSESVKC 120
  121 INTVIPLQTQ SFIVRLDKFL EIIFQLAQND ENDLVRAQIC ISFSFLLEFR PDKLVSHLDG 180
  181 IVQFMLHLIT TVNEEKVAIE ACEFLHAFAT SPNIPEHILQ PYVKDIVPIL LSKMVYNEES 240
  241 IVLLEASNDD DAFLEDKDED IKPIAPRIVK KKEAGNGEDA DDNEDDDDDD DDEDGDVDTQ 300
  301 WNLRKCSAAT LDVMTNILPH QVMDIAFPFL REHLGSDRWF IREATILALG AMAEGGMKYF 360
  361 NDGLPALIPF LVEQLNDKWA PVRKMTCWTL SRFSPWILQD HTEFLIPVLE PIINTLMDKK 420
  421 KDVQEAAISS VAVFIENADS ELVETLFYSQ LLTSFDKCLK YYKKKNLIIL YDAIGRFAEK 480
  481 CALDETAMQI ILPPLIEKWA LLSDSDKELW PLLECLSCVA SSLGERFMPM APEVYNRAFR 540
  541 ILCHCVELEA KSHQDPTIVV PEKDFIITSL DLIDGLVQGL GAHSQDLLFP QG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [689-858] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKDLTILKIM LECLQDPVHE VRQSCFALLG DIVYFFNSEL VIGNLEDFLK LIGTEIMHND  60
   61 DSDGTPAVIN AIWALGLISE RIDLNTYIID MSRIILDLFT TNTQIVDSSV MENLSVTIGK 120
  121 MGLTHPEVFS SGAFANDSNW NKWCLSVNAL DDVEEKSSAY MGFLKIINLT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.799 0.990 nuclear localization sequence binding a.118.1 ARM repeat

Predicted Domain #4
Region A:
Residues: [859-918] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STEVTMSNDT IHKIVTGLSS NVEANVFAQE IYTFLMNHSA QISAINFTPD EISFLQQFTS  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle