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View Structure Prediction Details

Protein: YAR009C
Organism: Saccharomyces cerevisiae
Length: 1196 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YAR009C.

Description E-value Query
Range		 Subject
Range
gi|1122342, gi|1... - gi|1204150|emb|CAA92352.1| unknown [Saccharomyces cerevisiae], gi|1122342|emb|CAA92360.1| unknown [S...
 626.0 [0..2] [1196..122]

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Predicted Domain #1
Region A:
Residues: [1-342] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METFTGYLKS TCFHQISPYP PSIMSIQVKV HANILILSFI ECLRMPMHRQ IRYSLKNNTI  60
   61 TYFNESDVDW SSAIDYQCPD CLIGKSTKHR HIKGSRLKYQ NSYEPFQYLH TDIFGPVHNL 120
  121 PKSAPSYFIS FTDETTKLRW VYPLHDRRED SILDVFTTIL AFIKNQFQAS VLVIQMDRGS 180
  181 EYTNRTLHKF LEKNGITPCY TTTADSRAHG VAERLNRTLL DDCRTQLQCS GLPNHLWFSA 240
  241 IEFSTIVRNS LASPKSKKSA RQHAGLAGLD ISTLLPFGQP VIVNDHNPNS KIHPRGIPGY 300
  301 ALHPSRNSYG YIIYLPSLKK TVDTTNYVIL QGKESRLDQF NY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.69897
Match: 1k6yA
Description: N-terminal Zn binding domain of HIV integrase; Retroviral integrase, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nuclease activity 1.94987701094917 bayes_pls_golite062009
ribonuclease activity 0.969438660919194 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.787213833707638 bayes_pls_golite062009
exonuclease activity 0.738049151007118 bayes_pls_golite062009
catalytic activity 0.709734459150736 bayes_pls_golite062009
3'-5' exonuclease activity 0.332143782945747 bayes_pls_golite062009
hydrolase activity 0.301910249637397 bayes_pls_golite062009
binding 0.205040227344888 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [343-519] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DALTFDEDLN RLTASYHSFI ASNEIQESND LNIESDHDFQ SDIELHPEQP RNVLSKAVSP  60
   61 TDSTPPSTHT EDSKRVSKTN IRAPREVDPN ISESNILPSK KRSSTPQISN IESTGSGGMH 120
  121 KLNVPLLAPM SQSNTHESSH ASKSKDFRHS DSYSENETNH TNVPISSTGG TNNKTVP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.5
Match: 1c0mA
Description: DNA-binding domain of retroviral integrase; Retroviral integrase, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nuclease activity 1.46638847734081 bayes_pls_golite062009
catalytic activity 0.626203923982956 bayes_pls_golite062009
ribonuclease activity 0.519152306822884 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.433654553131226 bayes_pls_golite062009
exonuclease activity 0.292985426209423 bayes_pls_golite062009
binding 0.27027344947123 bayes_pls_golite062009
hydrolase activity 0.104087157972011 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [520-590] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QISDQETEKR IIHRSPSIDA SPPENNSSHN IVPIKTPTTV SEQNTEESII ADLPLPDLPP  60
   61 ESPTEFPDPF K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [591-1196] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELPPINSHQT NSSLGGIGDS NAYTTINSKK RSLEDNETEI KVSRDTWNTK NMRSLEPPRS  60
   61 KKRIHLIAAV KAVKSIKPIR TTLRYDEAIT YNKDIKEKEK YIEAYHKEVN QLLKMNTWDT 120
  121 DKYYDRKEID PKRVINSMFI FNKKRDGTHK ARFVARGDIQ HPDTYDTGMQ SNTVHHYALM 180
  181 TSLSLALDNN YYITQLDISS AYLYADIKEE LYIRPPPHLG MNDKLIRLKK SLYGLKQSGA 240
  241 NWYETIKSYL IKQCGMEEVR GWSCVFKNSQ VTICLFVDDM ILFSKDLNAN KKIITTLKKQ 300
  301 YDTKIINLGE SDNEIQYDIL GLEIKYQRGK YMKLGMEKSL TEKLPKLNVP LNPKGKKLRA 360
  361 PGQPGLYIDQ DELEIDEDEY KEKVHEMQKL IGLASYVGYK FRFDLLYYIN TLAQHILFPS 420
  421 RQVLDMTYEL IQFMWDTRDK QLIWHKNKPT EPDNKLVAIS DASYGNQPYY KSQIGNIYLL 480
  481 NGKVIGGKST KASLTCTSTT EAEIHAISES VPLLNNLSYL IQELNKKPII KGLLTDSRST 540
  541 ISIIKSTNEE KFRNRFFGTK AMRLRDEVSG NNLYVYYIET KKNIADVMTK PLPIKTFKLL 600
  601 TNKWIH

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.59
Match: 1mu2A
Description: HIV RNase H (Domain of reverse transcriptase); HIV-1 reverse transcriptase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleotidyltransferase activity 1.61389461562101 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.895925817051023 bayes_pls_golite062009
DNA polymerase activity 0.71944542861368 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.710149896697621 bayes_pls_golite062009
binding 0.698775322116598 bayes_pls_golite062009
ribonuclease activity 0.519152306822884 bayes_pls_golite062009
catalytic activity 0.443190761359386 bayes_pls_golite062009
transferase activity 0.343279650271418 bayes_pls_golite062009
nucleic acid binding 0.0241260721327641 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle