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View Structure Prediction Details

Protein: CNE1
Organism: Saccharomyces cerevisiae
Length: 502 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CNE1.

Description E-value Query
Range
Subject
Range
CALX_YEAST - Calnexin homolog OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CNE1 PE=1 SV=1
CNE1 - Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; c...
0.0 [1..502] [1..502]
CANX - calnexin
gi|123994237, gi... - gi|60655615|gb|AAX32371.1| calnexin [synthetic construct], gi|124126943|gb|ABM92244.1| calnexin [syn...
0.0 [26..498] [64..503]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [26..498] [64..503]
CALX_CANLF - Calnexin OS=Canis lupus familiaris GN=CANX PE=1 SV=3
0.0 [26..498] [65..504]
gi|310085 - gi|310085|gb|AAA21015.1| calnexin [Rattus sp.]
CALX_RAT - Calnexin OS=Rattus norvegicus GN=Canx PE=1 SV=1
0.0 [26..498] [65..504]
CALX_MOUSE - Calnexin OS=Mus musculus GN=Canx PE=1 SV=1
0.0 [26..498] [65..504]

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Predicted Domain #1
Region A:
Residues: [1-247]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFSAYLWWL FLNLALVKGT SLLSNVTLAE DSFWEHFQAY TNTKHLNQEW ITSEAVNNEG  60
   61 SKIYGAQWRL SQGRLQGSAW DKGIAVRTGN AAAMIGHLLE TPINVSETDT LVVQYEIKLD 120
  121 NSLTCGGAFI KLMSGFMNVE ALKHYAPDTE GVELVFGPDY CAPEINGVQF AINKVDKITH 180
  181 ESKLRYLQEM PLSKLTDTSQ SHLYTLIIDE SAQSFQILID GKTVMVREHI EDKKKVNFEP 240
  241 PITPPLM

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [376-502]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPLYYEEQHP LRIENVISGV ILEFWSGSPN MLISNIYVGK NVTEAQIIGN KTWLMRDRAF  60
   61 RGSDGPTERK FMNSRLGNLQ TTFHNERESP NPFDRIIDRI LEQPLKFVLT AAVVLLTTSV 120
  121 LCCVVFT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 624.54902
Match: 1jhnA_
Description: Calnexin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
complement component C1q binding 4.81971897425786 bayes_pls_golite062009
steroid hormone receptor binding 4.11346029337178 bayes_pls_golite062009
androgen receptor binding 3.88449123711676 bayes_pls_golite062009
zymosan binding 3.41405218556083 bayes_pls_golite062009
nuclear hormone receptor binding 3.3517714661273 bayes_pls_golite062009
binding 3.24845777545007 bayes_pls_golite062009
hormone receptor binding 3.2405597896178 bayes_pls_golite062009
structural molecule activity 3.0286932947016 bayes_pls_golite062009
unfolded protein binding 2.94586353433162 bayes_pls_golite062009
protein binding 2.62442480878692 bayes_pls_golite062009
transcription regulator activity 2.5786381493734 bayes_pls_golite062009
transcription repressor activity 2.42862869142896 bayes_pls_golite062009
nucleic acid binding 2.33705817770533 bayes_pls_golite062009
cytoskeletal protein binding 2.16616430987996 bayes_pls_golite062009
actin binding 2.0669297251683 bayes_pls_golite062009
DNA binding 2.05388036301171 bayes_pls_golite062009
carbohydrate binding 1.90829797790335 bayes_pls_golite062009
sugar binding 1.89824804892868 bayes_pls_golite062009
receptor binding 1.70102429470678 bayes_pls_golite062009
molecular transducer activity 1.69567186252006 bayes_pls_golite062009
signal transducer activity 1.69567186252006 bayes_pls_golite062009
cation binding 1.67588357161378 bayes_pls_golite062009
metal ion binding 1.67588357161378 bayes_pls_golite062009
ion binding 1.66900324045723 bayes_pls_golite062009
NACHT domain binding 1.53382521801494 bayes_pls_golite062009
integrin binding 1.36513827550387 bayes_pls_golite062009
transporter activity 1.29150662073327 bayes_pls_golite062009
chaperone binding 1.28860282614448 bayes_pls_golite062009
glycosaminoglycan binding 1.25720635817943 bayes_pls_golite062009
protein complex binding 1.23240411516711 bayes_pls_golite062009
RNA binding 1.22339134958708 bayes_pls_golite062009
heparin binding 1.15897181987617 bayes_pls_golite062009
transcription factor activity 1.15427978494805 bayes_pls_golite062009
transcription activator activity 1.11465354227601 bayes_pls_golite062009
polysaccharide binding 1.09475063562581 bayes_pls_golite062009
transmembrane transporter activity 1.07075219961504 bayes_pls_golite062009
receptor activity 0.946182305131481 bayes_pls_golite062009
growth factor activity 0.850395354506359 bayes_pls_golite062009
pattern binding 0.83687933614214 bayes_pls_golite062009
transmembrane receptor activity 0.814690646803591 bayes_pls_golite062009
substrate-specific transporter activity 0.801327928563072 bayes_pls_golite062009
mRNA binding 0.67699218614597 bayes_pls_golite062009
monosaccharide binding 0.5678336426881 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.546870122670733 bayes_pls_golite062009
extracellular matrix structural constituent 0.52360080681204 bayes_pls_golite062009
calcium ion binding 0.416416901481401 bayes_pls_golite062009
hydrolase activity 0.374282208763552 bayes_pls_golite062009
structural constituent of cytoskeleton 0.160855218996334 bayes_pls_golite062009
growth factor binding 0.0922754536898114 bayes_pls_golite062009
cytokine binding 0.0273545648165503 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [248-375]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPDVSVAKPH DWDDRIRIPD PEAVKLSDRD ERDPLMIPHP DGTEPPEWNS SIPEYILDPN  60
   61 AQKPSWWKEL EHGEWIPPMI KNPLCTAERG CGQQIPGLIN NAKYKGPGEL NEIINPNYMG 120
  121 EWHPPEIE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 624.54902
Match: 1jhnA_
Description: Calnexin
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle