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View Structure Prediction Details

Protein: CYS3
Organism: Saccharomyces cerevisiae
Length: 394 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYS3.

Description E-value Query
Range
Subject
Range
gi|13699175, gi|... - gi|51261011|gb|AAH78869.1| Cystathionase (cystathionine gamma-lyase) [Rattus norvegicus], gi|1403106...
0.0 [3..392] [11..396]
CGL_MOUSE - Cystathionine gamma-lyase OS=Mus musculus GN=Cth PE=1 SV=1
0.0 [3..392] [11..396]
MEGL_FUSNN - L-methionine gamma-lyase OS=Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130...
0.0 [1..392] [1..395]
METB_HELPY - Cystathionine gamma-synthase OS=Helicobacter pylori (strain ATCC 700392 / 26695) GN=metB PE=1 SV=1
METB_HELPY - Cystathionine gamma-synthase OS=Helicobacter pylori GN=metB PE=3 SV=1
0.0 [11..392] [5..379]
FBpp0311547, Eip... - The gene Eip55E is referred to in FlyBase by the symbol Dmel\Eip55E (CG5345, FBgn0000566). It is a p...
gi|220946746, gi... - gi|220956348|gb|ACL90717.1| Eip55E-PA [synthetic construct], gi|220946746|gb|ACL85916.1| Eip55E-PA [...
0.0 [8..393] [9..391]
gi|5104901, gi|1... - gi|5104901|dbj|BAA80215.1| cystathionine gamma-lyase [Aeropyrum pernix K1], gi|14601268|ref|NP_14780...
gi|7437088 - pir||A72595 probable cystathionine gamma-lyase APE1226 - Aeropyrum pernix (strain K1)
0.0 [8..391] [3..383]
MCCB_BACSU - Cystathionine gamma-lyase OS=Bacillus subtilis GN=mccB PE=1 SV=1
gi|221324186 - gi|221324186|ref|ZP_03605480.1| cystathionine beta-lyase [Bacillus subtilis subsp. subtilis str. SMY...
gi|221319905 - gi|221319905|ref|ZP_03601199.1| cystathionine beta-lyase [Bacillus subtilis subsp. subtilis str. JH6...
gi|221314984 - gi|221314984|ref|ZP_03596789.1| cystathionine beta-lyase [Bacillus subtilis subsp. subtilis str. NCI...
MCCB_BACSU - Cystathionine gamma-lyase OS=Bacillus subtilis (strain 168) GN=mccB PE=1 SV=1
0.0 [3..390] [1..377]
gi|151941381 - gi|151941381|gb|EDN59752.1| cystathionine gamma-lyase [Saccharomyces cerevisiae YJM789]
CYS3 - Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathw...
CYS3_YEAST - Cystathionine gamma-lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CYS3 PE=1 SV=2
gi|190406663 - gi|190406663|gb|EDV09930.1| cystathionine gamma-lyase [Saccharomyces cerevisiae RM11-1a]
gi|207347984 - gi|207347984|gb|EDZ73979.1| YAL012Wp-like protein [Saccharomyces cerevisiae AWRI1631]
0.0 [1..394] [1..394]

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Predicted Domain #1
Region A:
Residues: [1-258]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLQESDKFA TKAIHAGEHV DVHGSVIEPI SLSTTFKQSS PANPIGTYEY SRSQNPNREN  60
   61 LERAVAALEN AQYGLAFSSG SATTATILQS LPQGSHAVSI GDVYGGTHRY FTKVANAHGV 120
  121 ETSFTNDLLN DLPQLIKENT KLVWIETPTN PTLKVTDIQK VADLIKKHAA GQDVILVVDN 180
  181 TFLSPYISNP LNFGADIVVH SATKYINGHS DVVLGVLATN NKPLYERLQF LQNAIGAIPS 240
  241 PFDAWLTHRG LKTLHLRV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [291-305]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNYDVVLKQH RDALG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 896.228787
Match: 1e5eA_
Description: Methionine gamma-lyase, MGL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor 2.82824364293374 bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity 2.82824364293374 bayes_pls_golite062009
catalytic activity 2.29878871754893 bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity 1.87460342369605 bayes_pls_golite062009
transcription regulator activity 1.67701710033155 bayes_pls_golite062009
DNA binding 1.4774443071095 bayes_pls_golite062009
transferase activity 1.44093490824786 bayes_pls_golite062009
nucleic acid binding 1.39741122443159 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.28316822767388 bayes_pls_golite062009
transaminase activity 1.24990480711889 bayes_pls_golite062009
transcription factor activity 1.15775909410582 bayes_pls_golite062009
binding 1.09053123792737 bayes_pls_golite062009
O-phospho-L-serine:2-oxoglutarate aminotransferase activity 0.994935084630764 bayes_pls_golite062009
ligase activity 0.827063849687833 bayes_pls_golite062009
carbon-sulfur lyase activity 0.698312655247044 bayes_pls_golite062009
cystathionine beta-lyase activity 0.6849039330512 bayes_pls_golite062009
vitamin binding 0.66463470119531 bayes_pls_golite062009
cystathionine gamma-lyase activity 0.505859361763689 bayes_pls_golite062009
alanine-glyoxylate transaminase activity 0.48682493494502 bayes_pls_golite062009
O-acyltransferase activity 0.452440867878365 bayes_pls_golite062009
cysteine synthase activity 0.417849187928985 bayes_pls_golite062009
structural molecule activity 0.347975812448725 bayes_pls_golite062009
glycine hydroxymethyltransferase activity 0.271623203801431 bayes_pls_golite062009
pyridoxal phosphate binding 0.16957228630576 bayes_pls_golite062009
vitamin B6 binding 0.16957228630576 bayes_pls_golite062009
adenosylmethionine-8-amino-7-oxononanoate transaminase activity 0.0669652799570574 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [259-290]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQAALSANKI AEFLAADKEN VVAVNYPGLK TH

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [306-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGMISFRIKG GAEAASKFAS STRLFTLAES LGGIESLLEV PAVMTHGGIP KEAREASGVF  60
   61 DDLVRISVGI EDTDDLLEDI KQALKQATN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 896.228787
Match: 1e5eA_
Description: Methionine gamma-lyase, MGL
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle