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View Structure Prediction Details

Protein: FBpp0300193, RSG7-PA
Organism: Drosophila melanogaster
Length: 647 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0300193, RSG7-PA.

Description E-value Query
Range
Subject
Range
gi|109479610, gi... - gi|109479610|ref|XP_001056155.1| PREDICTED: similar to regulator of G-protein signaling 6 isoform 2 ...
600.0 [0..196] [639..5]

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Predicted Domain #1
Region A:
Residues: [1-211]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTMNSEADK TQATNASSTA APAKTDCTSS NSSDPLAVAI PEPQSATAVV GGGAGGAAPG  60
   61 TATPSPTPLA NGSNNGTGSS VSPAATGTGA VATAASAPAA AGTTSASPPA SNPTTASTST 120
  121 ASVVGAKTAA ATTTSSSSAT SSSTAAAGSK QSGSSGGLLT VSGNHHHHHH AHPQQSAAGQ 180
  181 SAAQPPQPPT ATALAVPSAS HHQRGGKNED A

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [212-300]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNILVYKKME AIIEKMQAES TGVAVRTVKA FMSKVPSVFT GADLVAWILK NFDVEDVTEA  60
   61 LHFAHLLSSH GYIFPIDDHA LTVKNDGTF

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 32.113509
Match: PF00610.12
Description: No description for PF00610.12 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [301-397]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YRFQTPYFWP SNCWEPENTD YAVYLCKRTM QNKTRLELAD YEAENLAKLQ KMFSRKWEFI  60
   61 FMQAESQSKV AKKRDKLERK VLDSQERAFW DVHRPMP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [398-484]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GCVNTTEIDI KKAYRRGGSS HGTGSAGASL AKNPVEQLTR IIALRKQKLE RRTIKVSKAA  60
   61 EALVAYYDQY NEFDYFITSP ELPNPWQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.53
Match: 1xhmB
Description: The Crystal Structure of a Biologically Active Peptide (SIGK) Bound to a G Protein Beta:Gamma Heterodimer
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.90500749049821 bayes_pls_golite062009
signal transducer activity 1.70315911322844 bayes_pls_golite062009
molecular transducer activity 1.70315911322844 bayes_pls_golite062009
GTPase activity 0.944482131496004 bayes_pls_golite062009
protein binding 0.40736300061233 bayes_pls_golite062009
receptor binding 0.363468238376214 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [485-647]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDSTEMWDTE KNSKEVPVRR VKRWAFSLRE LLNDAIGREQ FTKFLEKEYS GENLKFWESV  60
   61 QEMKALPQSE IKEAIQKIWQ EFLAPEAPCP VNVDSKSVEL AREAVNSPSG PNRWCFDVAA 120
  121 SHVYHLMKSD SYSRYLRSDM YKDYLNCSRK KIKSIPNLFG VKR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.154902
Match: 2es0A
Description: Structure of the regulator of G-protein signaling domain of RGS6
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle