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View Structure Prediction Details

Protein: eps-8
Organism: Caenorhabditis elegans
Length: 665 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eps-8.

Description E-value Query
Range
Subject
Range
eps-8 - status:Confirmed UniProt:Q7YTG1 protein_id:CAE45095.2
533.0 [0..1] [665..181]

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Predicted Domain #1
Region A:
Residues: [1-173]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPFYPPDDAS ISSETSEMFE RDVNTLNRCF DDIERFVARI QSAALAQREI EQQNHRYRTA  60
   61 NRRDKKNQQP PDPNGILFMR AQLPLESEFV DILKKFKLSF NLLAKLKNHI HEPNAPELLH 120
  121 FLFTPLAVIL EACHWGLGRN VAPTVASPLL SLEARELMQN CLTSHESDIW MSL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [174-233]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEAWRTPPED WTKPLPPPYR PIFNDGFAPY GVADRAMATP NQIHRGHSAP PEHFRQPPPR  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [234-472]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERNMVDTLEF DRLTLERERL EFEKAKIMER ESRLRHEEKQ IEDEKRRMHA EKDLITKETT  60
   61 QPVPPPAAVV THQPITKRYD PPISISPPPQ RNNYSHVKVT VDSDTSPRQQ AFIDDIVAKG 120
  121 GKLAVVTYDR GGQNTKELTV HKGEYLEVIF DERNWWECKN MHQRVGYVPH TILSMVPFEQ 180
  181 QQYASPNHHN NSSSTGGYNN GHHQGPAQNV YRPPPPPLVS DAGVQVEIRR EHVAPPPPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.522879
Match: 2eyzA
Description: No description for 2eyzA was found.

Predicted Domain #4
Region A:
Residues: [473-559]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VVIPPPPPPV RTPTMEELLR MQQQQQQKQR KPPVEEPVYQ PQPAQRAGLE IWRRNQNPQL  60
   61 IQEVTETVGQ HSGDILRPAM QRATRVA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.69897
Match: 1griA
Description: Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.375837873453985 bayes_pls_golite062009
protein binding 0.25580402341401 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [560-665]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INEKSSPEDV TRWLQEKGFS PRVIDLLDGQ DGANLFSLSK LHLQQACGRD EGGYLYSQLL  60
   61 VQKKRSGFRT HTGDELKAIL NHRRTHVELS NEAAADEPVF TINPIL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.0
Match: 2e8mA
Description: No description for 2e8mA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle