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View Structure Prediction Details

Protein: eps-8
Organism: Caenorhabditis elegans
Length: 665 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eps-8.

Description E-value Query
Range
Subject
Range
eps-8 - status:Confirmed UniProt:Q7YTG1 protein_id:CAE45095.2
533.0 [0..1] [665..181]

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Predicted Domain #1
Region A:
Residues: [1-173]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPFYPPDDAS ISSETSEMFE RDVNTLNRCF DDIERFVARI QSAALAQREI EQQNHRYRTA  60
   61 NRRDKKNQQP PDPNGILFMR AQLPLESEFV DILKKFKLSF NLLAKLKNHI HEPNAPELLH 120
  121 FLFTPLAVIL EACHWGLGRN VAPTVASPLL SLEARELMQN CLTSHESDIW MSL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [174-233]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEAWRTPPED WTKPLPPPYR PIFNDGFAPY GVADRAMATP NQIHRGHSAP PEHFRQPPPR  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [234-472]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERNMVDTLEF DRLTLERERL EFEKAKIMER ESRLRHEEKQ IEDEKRRMHA EKDLITKETT  60
   61 QPVPPPAAVV THQPITKRYD PPISISPPPQ RNNYSHVKVT VDSDTSPRQQ AFIDDIVAKG 120
  121 GKLAVVTYDR GGQNTKELTV HKGEYLEVIF DERNWWECKN MHQRVGYVPH TILSMVPFEQ 180
  181 QQYASPNHHN NSSSTGGYNN GHHQGPAQNV YRPPPPPLVS DAGVQVEIRR EHVAPPPPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.522879
Match: 2eyzA
Description: No description for 2eyzA was found.

Predicted Domain #4
Region A:
Residues: [473-559]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VVIPPPPPPV RTPTMEELLR MQQQQQQKQR KPPVEEPVYQ PQPAQRAGLE IWRRNQNPQL  60
   61 IQEVTETVGQ HSGDILRPAM QRATRVA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.69897
Match: 1griA
Description: Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.375837873453985 bayes_pls_golite062009
protein binding 0.25580402341401 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [560-665]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INEKSSPEDV TRWLQEKGFS PRVIDLLDGQ DGANLFSLSK LHLQQACGRD EGGYLYSQLL  60
   61 VQKKRSGFRT HTGDELKAIL NHRRTHVELS NEAAADEPVF TINPIL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.0
Match: 2e8mA
Description: No description for 2e8mA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle