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View Structure Prediction Details

Protein: acr-21
Organism: Caenorhabditis elegans
Length: 469 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for acr-21.

Description E-value Query
Range
Subject
Range
gi|73974924 - gi|73974924|ref|XP_539232.2| PREDICTED: similar to cholinergic receptor, nicotinic, alpha polypeptid...
392.0 [0..2] [461..107]

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Predicted Domain #1
Region A:
Residues: [1-317]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLYRDLLYD YNNEVRPSVH SKEPINVTFV FSLTQIIDVD ERNQILTTNS WIRLHWVDYK  60
   61 LVWDPRLYQN VTRIHIPSDK IWKPDIILYN NADAQYMKSV MSTDVIVDYL GNIHWPLSAI 120
  121 FTSSCPLDVK HYPFDRQTCI LKYASWAYDG TKIDLLLKSE QGDLTNYITN TEWSLIGIRA 180
  181 EKNQVIYSCC PEPYPFIDVH VTIERRAMFY VFNLILPCVL ISLIALMGFY MPTDSGEKVT 240
  241 LGITSLLSTT VFLMMVAEGM PPTAEALPLI GIYFGVTIML VALGTAMTVF TVNIHHTGVH 300
  301 GYPVPPFLQI FAFRYLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 76.69897
Match: 2bg9A
Description: Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [318-469]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KILFVRIEPY HSIAHHVRYM YQKEHPTECT LSASVHYKRL HDFDANVAKK EEQYGLQRDM  60
   61 SNLSVISANV HCNPDDRLLL GSQSSQKNLN KFDSEKNLRS SLSIRSGSPT AKKKVGSIVT 120
  121 ITLNYCLYIL TFKITGSRSC IEYCPKYKNN GD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.0
Match: 1oedC
Description: Acetylcholine receptor protein, delta chain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
acetylcholine binding 13.9752632471881 bayes_pls_golite062009
acetylcholine receptor activity 13.7533645836795 bayes_pls_golite062009
nicotinic acetylcholine-activated cation-selective channel activity 13.1511875247796 bayes_pls_golite062009
extracellular ligand-gated ion channel activity 11.7813202122163 bayes_pls_golite062009
excitatory extracellular ligand-gated ion channel activity 11.7813202122163 bayes_pls_golite062009
cation channel activity 11.1823056937132 bayes_pls_golite062009
ion channel activity 11.1753684044644 bayes_pls_golite062009
passive transmembrane transporter activity 11.0903806681397 bayes_pls_golite062009
channel activity 11.0903806681397 bayes_pls_golite062009
gated channel activity 11.0397691626728 bayes_pls_golite062009
metal ion transmembrane transporter activity 10.9870635461822 bayes_pls_golite062009
substrate-specific channel activity 10.9375522860542 bayes_pls_golite062009
ligand-gated ion channel activity 9.34902726749692 bayes_pls_golite062009
ligand-gated channel activity 9.34902726749692 bayes_pls_golite062009
amine binding 9.11982124959723 bayes_pls_golite062009
ion transmembrane transporter activity 7.22265353460749 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 6.7875346065164 bayes_pls_golite062009
cation transmembrane transporter activity 6.75385972663331 bayes_pls_golite062009
chloride channel regulator activity 6.26397218402661 bayes_pls_golite062009
transmembrane receptor activity 5.4080353535498 bayes_pls_golite062009
receptor activity 5.11329651194787 bayes_pls_golite062009
transporter activity 5.11262082564788 bayes_pls_golite062009
transmembrane transporter activity 5.03439798256257 bayes_pls_golite062009
substrate-specific transporter activity 4.91314874981447 bayes_pls_golite062009
neurotransmitter binding 4.25797760547212 bayes_pls_golite062009
neurotransmitter receptor activity 4.15404686068319 bayes_pls_golite062009
molecular transducer activity 4.12549692767753 bayes_pls_golite062009
signal transducer activity 4.12549692767753 bayes_pls_golite062009
binding 2.4916526322278 bayes_pls_golite062009
beta-amyloid binding 1.6057916207188 bayes_pls_golite062009
G-protein coupled receptor activity 1.42422063123689 bayes_pls_golite062009
serotonin binding 1.33584589886834 bayes_pls_golite062009
serotonin-activated cation-selective channel activity 1.31324203158511 bayes_pls_golite062009
1.15330735898282 bayes_pls_golite062009
channel regulator activity 1.13923307634251 bayes_pls_golite062009
toxin binding 0.79651014283675 bayes_pls_golite062009
drug binding 0.64715018605883 bayes_pls_golite062009
protein binding 0.406954670483187 bayes_pls_golite062009
kinase binding 0.365355763029699 bayes_pls_golite062009
protein kinase binding 0.350601457777817 bayes_pls_golite062009

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