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View Structure Prediction Details

Protein: pig-1
Organism: Caenorhabditis elegans
Length: 703 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pig-1.

Description E-value Query
Range
Subject
Range
gi|73964111 - gi|73964111|ref|XP_868650.1| PREDICTED: similar to MAP/microtubule affinity-regulating kinase 3 isof...
524.0 [0..2] [702..47]

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Predicted Domain #1
Region A:
Residues: [1-397]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKYEVLQGF YAVHDELGSG GFGKVRLATH LLTNQKVAIK IIDKKQLGHD LPRVQTEMDA  60
   61 LRNLSHQNIC RLYHYIETED KFFIVMEYCS GGEMFDYIVR KERLEESEAR HFFRQLVSAI 120
  121 AFVHSQGYAH RDLKPENLLL TEDLHLKLID FGLCAKTEKG RIDKHNLDTC CGSPAYAAPE 180
  181 LIQGLQYKGN EADVWSMGIL LYTLLVGALP FEDDNMQIMY KKIQSGCFYE PEFLSPLSKQ 240
  241 LLRAMLQVVP ERRISVKKLL EHDWLNHKYT QPVKWNTIYD KNFIDRDVAR VMSKYYGFES 300
  301 TDKMIEKIKE WNFDYMTSTY YALLHRKRNG MEIILPMVRN STNTAPPNVQ NILCSPTIHA 360
  361 SLENNLDKSG LEDDDSDPSS ISSSSDISAR LKKNCVV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 85.0
Match: 2qnjA
Description: No description for 2qnjA was found.

Predicted Domain #2
Region A:
Residues: [398-582]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDESSSSRFV KPMSPAAEKD KKMSYVNAML TMPSQFTGRS PLRIPESPMS VRSSDSASLG  60
   61 SAATPSRGGV KDNDKENAST GKNYRMGAST CKSRGPLKIT GVEEGTMKSV YTTPNTRPTL 120
  121 RGLFSPGNAE HKKRQRARSS DRASIGMPPG SPVSIGSAHS ANNADGRTPR SRIKTNRLPQ 180
  181 RVFTS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [583-703]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LERKKEKLIT LLTPRKMQRD SPQVLKDVKN MVNVSMTASQ DPEEVRNLLK KVFDDERMRY  60
   61 ELNGWKFLAT QETVHGWMTV ELEIVRLQMF DKVGIRRKRL KGDAFMYKKV CEKILQMAKI 120
  121 E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.30103
Match: 1ul7A
Description: Solution structure of kinase associated domain 1 of mouse MAP/microtubule affinity-regulating kinase 3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein kinase activity 4.05475891009228 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 4.04751809021925 bayes_pls_golite062009
kinase activity 3.88704262604357 bayes_pls_golite062009
protein serine/threonine kinase activity 3.7974128326421 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 3.55786569314106 bayes_pls_golite062009
transferase activity 2.750643926194 bayes_pls_golite062009
binding 2.41732321506551 bayes_pls_golite062009
ATP binding 1.44435058039859 bayes_pls_golite062009
adenyl ribonucleotide binding 1.41005152726625 bayes_pls_golite062009
adenyl nucleotide binding 1.38971642420542 bayes_pls_golite062009
ribonucleotide binding 1.16863558166547 bayes_pls_golite062009
purine ribonucleotide binding 1.16859376715941 bayes_pls_golite062009
purine nucleotide binding 1.15633908642115 bayes_pls_golite062009
nucleotide binding 1.14964488472581 bayes_pls_golite062009
catalytic activity 0.836142537655721 bayes_pls_golite062009
protein binding 0.704339182896017 bayes_pls_golite062009
AMP-activated protein kinase activity 0.496765880715405 bayes_pls_golite062009
magnesium ion binding 0.439688030503848 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle