YRC Public Data Repository - Protein Structure Prediction

Protein:	FMT_ECOLI
Organism:	Escherichia coli
Length:	315 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FMT_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|193066482, gi... - gi\|75255414\|ref\|ZP_00727226.1\| COG0223: Methionyl-tRNA formyltransferase [Escherichia coli E22], gi\|... gi\|194430290, gi... - gi\|75208438\|ref\|ZP_00708767.1\| COG0223: Methionyl-tRNA formyltransferase [Escherichia coli B171], gi... FMT_ECO27 - Methionyl-tRNA formyltransferase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=fmt PE=3 SV... FMT_ECO55 - Methionyl-tRNA formyltransferase OS=Escherichia coli (strain 55989 / EAEC) GN=fmt PE=3 SV=1 sp\|B7UK11\|FMT_ECO27 - Methionyl-tRNA formyltransferase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=fmt PE=3 SV...	418.0	[0..1]	[315..1]
gi\|254795224, gi... - gi\|254795224\|ref\|YP_003080061.1\| 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferas... FMT_ECO57 - Methionyl-tRNA formyltransferase OS=Escherichia coli O157:H7 GN=fmt PE=3 SV=3 gi\|25320684, gi\|... - pir\|\|E85993 hypothetical protein fmt [imported] - Escherichia coli (strain O157:H7, substrain EDL93... gi\|168758515, gi... - gi\|189354684\|gb\|EDU73103.1\| methionyl-tRNA formyltransferase [Escherichia coli O157:H7 str. EC4401],... gi\|15803815, gi\|... - gi\|15803815\|ref\|NP_289849.1\| methionyl-tRNA formyltransferase [Escherichia coli O157:H7 EDL933], gi\|... gi\|217320751, gi... - gi\|217324530\|ref\|ZP_03440614.1\| methionyl-tRNA formyltransferase [Escherichia coli O157:H7 str. TW14... FMT_ECO5E - Methionyl-tRNA formyltransferase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=fmt PE=3 SV=1 gi\|208818701, gi... - gi\|208818701\|ref\|ZP_03259021.1\| methionyl-tRNA formyltransferase [Escherichia coli O157:H7 str. EC40... gi\|208733665, gi... - gi\|208812388\|ref\|ZP_03253717.1\| methionyl-tRNA formyltransferase [Escherichia coli O157:H7 str. EC40... gi\|188998872, gi... - gi\|188998872\|gb\|EDU67858.1\| methionyl-tRNA formyltransferase [Escherichia coli O157:H7 str. EC4076],... gi\|168777855, gi... - gi\|187767010\|gb\|EDU30854.1\| methionyl-tRNA formyltransferase [Escherichia coli O157:H7 str. EC4196],... gi\|189361852, gi... - gi\|189361852\|gb\|EDU80271.1\| methionyl-tRNA formyltransferase [Escherichia coli O157:H7 str. EC4486],... gi\|189365130, gi... - gi\|189365130\|gb\|EDU83546.1\| methionyl-tRNA formyltransferase [Escherichia coli O157:H7 str. EC4501],... gi\|208807557, gi... - gi\|208807557\|ref\|ZP_03249894.1\| methionyl-tRNA formyltransferase [Escherichia coli O157:H7 str. EC42... gi\|195939835 - gi\|195939835\|ref\|ZP_03085217.1\| methionyl-tRNA formyltransferase [Escherichia coli O157:H7 str. EC40... gi\|15833407, gi\|... - gi\|15833407\|ref\|NP_312180.1\| methionyl-tRNA formyltransferase [Escherichia coli O157:H7 str. Sakai],... gi\|168802717, gi... - gi\|189375352\|gb\|EDU93768.1\| methionyl-tRNA formyltransferase [Escherichia coli O157:H7 str. EC508], ... gi\|189374012, gi... - gi\|189374012\|gb\|EDU92428.1\| methionyl-tRNA formyltransferase [Escherichia coli O157:H7 str. EC869], ...	417.0	[0..1]	[315..1]
gi\|188487856, gi... - gi\|75511167\|ref\|ZP_00733879.1\| COG0223: Methionyl-tRNA formyltransferase [Escherichia coli 53638], g...	417.0	[0..1]	[315..1]
gi\|24114565, gi\|... - gi\|24114565\|ref\|NP_709075.1\| methionyl-tRNA formyltransferase [Shigella flexneri 2a str. 301], gi\|24... FMT_SHIF8 - Methionyl-tRNA formyltransferase OS=Shigella flexneri serotype 5b (strain 8401) GN=fmt PE=3 SV=1 gi\|30064609, gi\|... - gi\|30064609\|ref\|NP_838780.1\| methionyl-tRNA formyltransferase [Shigella flexneri 2a str. 2457T], gi\|... FMT_SHIFL - Methionyl-tRNA formyltransferase OS=Shigella flexneri GN=fmt PE=3 SV=1	416.0	[0..1]	[315..1]
gi\|190900661, gi... - gi\|75227394\|ref\|ZP_00714170.1\| COG0223: Methionyl-tRNA formyltransferase [Escherichia coli B7A], gi\|... FMT_ECO24 - Methionyl-tRNA formyltransferase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=fmt PE=3 SV... FMT_ECO8A - Methionyl-tRNA formyltransferase OS=Escherichia coli O8 (strain IAI1) GN=fmt PE=3 SV=1	416.0	[0..1]	[315..1]
gi\|75214907, gi\|... - gi\|75214907\|ref\|ZP_00713386.1\| COG0223: Methionyl-tRNA formyltransferase [Escherichia coli E110019],...	416.0	[0..1]	[315..1]
FMT_SHIDS - Methionyl-tRNA formyltransferase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=fmt PE=3 SV=1	415.0	[0..1]	[314..1]
FMT_SHISS - Methionyl-tRNA formyltransferase OS=Shigella sonnei (strain Ss046) GN=fmt PE=3 SV=1	415.0	[0..1]	[314..1]
FMT_ECOLI - (P23882) Methionyl-tRNA formyltransferase (EC 2.1.2.9)	414.0	[0..2]	[315..1]

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Predicted Domain #1

Region A:
Residues: [1-315]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSESLRIIFA GTPDFAARHL DALLSSGHNV VGVFTQPDRP AGRGKKLMPS PVKVLAEEKG  60
   61 LPVFQPVSLR PQENQQLVAE LQADVMVVVA YGLILPKAVL EMPRLGCINV HGSLLPRWRG 120
  121 AAPIQRSLWA GDAETGVTIM QMDVGLDTGD MLYKLSCPIT AEDTSGTLYD KLAELGPQGL 180
  181 ITTLKQLADG TAKPEVQDET LVTYAEKLSK EEARIDWSLS AAQLERCIRA FNPWPMSWLE 240
  241 IEGQPVKVWK ASVIDTATNA APGTILEANK QGIQVATGDG ILNLLSLQPA GKKAMSAQDL 300
  301 LNSRREWFVP GNRLV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	116.0
Match:	1fmtA
Description:	Methionyl-tRNAfmet formyltransferase, C-terminal domain; Methionyl-tRNAfmet formyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methionyl-tRNA formyltransferase activity	5.51013755462273	bayes_pls_golite062009
hydroxymethyl-, formyl- and related transferase activity	5.19882604023997	bayes_pls_golite062009
ligase activity	2.41579019065074	bayes_pls_golite062009
methyltransferase activity	2.27572765999587	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	2.20102068445328	bayes_pls_golite062009
catalytic activity	2.16003793103722	bayes_pls_golite062009
glycine hydroxymethyltransferase activity	1.99841214906509	bayes_pls_golite062009
transferase activity	1.01502594768782	bayes_pls_golite062009
DNA N-glycosylase activity	0.809924940479886	bayes_pls_golite062009
binding	0.752059276178195	bayes_pls_golite062009
nucleic acid binding	0.698214709916015	bayes_pls_golite062009
DNA binding	0.421388681127685	bayes_pls_golite062009
phosphoribosylglycinamide formyltransferase activity	0.0567687847434473	bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds	0.0124799003650303	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: