YRC Public Data Repository - Protein Structure Prediction

Protein:	FRDB_ECOLI
Organism:	Escherichia coli
Length:	244 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRDB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|85374186, gi\|... - gi\|85374186\|ref\|YP_458248.1\| succinate dehydrogenase iron-sulfur subunit [Erythrobacter litoralis HT...	227.0	[0..2]	[235..23]
gi\|25284631 - pir\|\|D87686 succinate dehydrogenase, iron-sulfur protein [imported] - Caulobacter crescentus gi\|16127756, gi\|... - gi\|16127756\|ref\|NP_422320.1\| succinate dehydrogenase iron-sulfur subunit [Caulobacter crescentus CB1... gi\|220965750, gi... - gi\|221236577\|ref\|YP_002519014.1\| succinate dehydrogenase iron-sulfur protein [Caulobacter crescentus...	227.0	[0..4]	[235..25]
gi\|78700193, gi\|... - gi\|78700193\|ref\|ZP_00864650.1\| Succinate dehydrogenase/fumarate reductase iron-sulfur protein [Alkal...	224.0	[0..9]	[235..29]
gi\|34580973, gi\|... - gi\|34580973\|ref\|ZP_00142453.1\| succinate dehydrogenase iron-sulfur protein [Rickettsia sibirica 246]...	223.0	[0..1]	[236..24]
DHSB_RICCN - Succinate dehydrogenase iron-sulfur subunit OS=Rickettsia conorii GN=sdhB PE=3 SV=1 SDHB_RICCN - Succinate dehydrogenase iron-sulfur subunit OS=Rickettsia conorii (strain ATCC VR-613 / Malish 7) GN...	223.0	[0..1]	[236..24]
gi\|87200336, gi\|... - gi\|87200336\|ref\|YP_497593.1\| succinate dehydrogenase iron-sulfur subunit [Novosphingobium aromaticiv...	222.0	[0..2]	[235..23]
gi\|146402557, gi... - gi\|88938934\|ref\|ZP_01144386.1\| succinate dehydrogenase and fumarate reductase iron-sulfur protein [A...	222.0	[0..5]	[235..26]
gi\|88794850, gi\|... - gi\|88794850\|ref\|ZP_01110554.1\| succinate dehydrogenase catalytic subunit [Alteromonas macleodii 'Dee... gi\|239993977 - gi\|239993977\|ref\|ZP_04714501.1\| succinate dehydrogenase catalytic subunit [Alteromonas macleodii ATC...	222.0	[0..5]	[237..1]
gi\|157827942, gi... - gi\|157827942\|ref\|YP_001494184.1\| succinate dehydrogenase iron-sulfur subunit [Rickettsia rickettsii ... gi\|42453230 - gi\|42453230\|ref\|ZP_00153137.1\| COG0479: Succinate dehydrogenase/fumarate reductase, Fe-S protein sub...	222.0	[0..1]	[236..24]
gi\|53804152, gi\|... - gi\|53804152\|ref\|YP_113997.1\| succinate dehydrogenase iron-sulfur subunit [Methylococcus capsulatus s...	222.0	[0..2]	[235..23]

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Predicted Domain #1

Region A:
Residues: [1-244]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEMKNLKIE VVRYNPEVDT APHSAFYEVP YDATTSLLDA LGYIKDNLAP DLSYRWSCRM  60
   61 AICGSCGMMV NNVPKLACKT FLRDYTDGMK VEALANFPIE RDLVVDMTHF IESLEAIKPY 120
  121 IIGNSRTADQ GTNIQTPAQM AKYHQFSGCI NCGLCYAACP QFGLNPEFIG PAAITLAHRY 180
  181 NEDSRDHGKK ERMAQLNSQN GVWSCTFVGY CSEVCPKHVD PAAAIQQGKV ESSKDFLIAT 240
  241 LKPR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.69897
Match:	1kf6B
Description:	Fumarate reductase; Fumarate reductase iron-sulfur protein, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
succinate dehydrogenase (ubiquinone) activity	8.67170708058767	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	8.67170708058767	bayes_pls_golite062009
electron carrier activity	5.46307392364196	bayes_pls_golite062009
succinate dehydrogenase activity	5.17247395944711	bayes_pls_golite062009
4 iron, 4 sulfur cluster binding	4.95798078106244	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	4.38887210619429	bayes_pls_golite062009
oxidoreductase activity	4.24568355093737	bayes_pls_golite062009
NADH dehydrogenase activity	4.24327638063454	bayes_pls_golite062009
NADH dehydrogenase (quinone) activity	4.15859537745252	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	3.78210410787032	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	3.67682177056786	bayes_pls_golite062009
iron-sulfur cluster binding	3.28424324316751	bayes_pls_golite062009
metal cluster binding	3.28424324316751	bayes_pls_golite062009
binding	1.29066915338738	bayes_pls_golite062009
protein binding	0.507343948317508	bayes_pls_golite062009
catalytic activity	0.105119876745552	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: