YRC Public Data Repository - Protein Structure Prediction

Protein:	UNG_ECOLI
Organism:	Escherichia coli
Length:	229 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UNG_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|83586768, gi\|... - gi\|83586768\|ref\|ZP_00925399.1\| COG0692: Uracil DNA glycosylase [Escherichia coli 101-1], gi\|19443765... gi\|6435761\|pdb\|1... - Chain A, Crystal Structure Of Escherichia Coli Uracil Dna Glycosylase And Its Complexes With Uracil ... gi\|6435761 - gi\|6435761\|pdb\|1EUG\|A Chain A, Crystal Structure Of Escherichia Coli Uracil Dna Glycosylase And Its ... gi\|251785907, gi... - gi\|251785907\|ref\|YP_003000211.1\| hypothetical protein B21_02438 [Escherichia coli BL21], gi\|24237818... gi\|253323564, gi... - gi\|254289316\|ref\|YP_003055064.1\| uracil-DNA glycosylase [Escherichia coli BL21(DE3)], gi\|253978623\|g... gi\|253974456, gi... - gi\|254162555\|ref\|YP_003045663.1\| uracil-DNA glycosylase [Escherichia coli B str. REL606], gi\|2539744...	406.0	[0..1]	[229..1]
UNG_ECOLU - Uracil-DNA glycosylase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=ung PE=3 SV=1 UNG_ECO57 - Uracil-DNA glycosylase OS=Escherichia coli O157:H7 GN=ung PE=3 SV=3 gi\|25289606 - pir\|\|D85904 uracil-DNA-glycosylase [imported] - Escherichia coli (strain O157:H7, substrain EDL933) gi\|208813886, gi... - gi\|208813886\|ref\|ZP_03255215.1\| uracil-DNA glycosylase [Escherichia coli O157:H7 str. EC4045], gi\|20... gi\|15803107, gi\|... - gi\|15803107\|ref\|NP_289138.1\| uracil-DNA glycosylase [Escherichia coli O157:H7 EDL933], gi\|12517001\|g... gi\|208739212, gi... - gi\|208819089\|ref\|ZP_03259409.1\| uracil-DNA glycosylase [Escherichia coli O157:H7 str. EC4042], gi\|20... UNG_ECO5E - Uracil-DNA glycosylase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=ung PE=3 SV=1 gi\|217327894, gi... - gi\|217327894\|ref\|ZP_03443977.1\| uracil-DNA glycosylase [Escherichia coli O157:H7 str. TW14588], gi\|2... gi\|168790381, gi... - gi\|189370147\|gb\|EDU88563.1\| uracil-DNA glycosylase [Escherichia coli O157:H7 str. EC869], gi\|1687903... gi\|189376162, gi... - gi\|189376162\|gb\|EDU94578.1\| uracil-DNA glycosylase [Escherichia coli O157:H7 str. EC508], gi\|1688016... gi\|195936728 - gi\|195936728\|ref\|ZP_03082110.1\| uracil-DNA glycosylase [Escherichia coli O157:H7 str. EC4024] gi\|208726281, gi... - gi\|208806480\|ref\|ZP_03248817.1\| uracil-DNA glycosylase [Escherichia coli O157:H7 str. EC4206], gi\|20... gi\|168765026, gi... - gi\|189365092\|gb\|EDU83508.1\| uracil-DNA glycosylase [Escherichia coli O157:H7 str. EC4501], gi\|168765... UNG_SHIDS - Uracil-DNA glycosylase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=ung PE=3 SV=1 gi\|189362222, gi... - gi\|189362222\|gb\|EDU80641.1\| uracil-DNA glycosylase [Escherichia coli O157:H7 str. EC4486], gi\|168768... gi\|168773491, gi... - gi\|187770722\|gb\|EDU34566.1\| uracil-DNA glycosylase [Escherichia coli O157:H7 str. EC4196], gi\|168773... gi\|168778559, gi... - gi\|189003330\|gb\|EDU72316.1\| uracil-DNA glycosylase [Escherichia coli O157:H7 str. EC4076], gi\|168778... gi\|189355281, gi... - gi\|189355281\|gb\|EDU73700.1\| uracil-DNA glycosylase [Escherichia coli O157:H7 str. EC4401], gi\|168757... gi\|254794531, gi... - gi\|254794531\|ref\|YP_003079368.1\| uracil-DNA-glycosylase [Escherichia coli O157:H7 str. TW14359], gi\|...	405.0	[0..1]	[229..1]
UNG_ECOSM - Uracil-DNA glycosylase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=ung PE=3 SV=1 UNG_ECO27 - Uracil-DNA glycosylase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=ung PE=3 SV=1 gi\|75228845, gi\|... - gi\|75228845\|ref\|ZP_00715446.1\| COG0692: Uracil DNA glycosylase [Escherichia coli B7A], gi\|191167979\|... UNG_ECOK1 - Uracil-DNA glycosylase OS=Escherichia coli O1:K1 / APEC GN=ung PE=3 SV=1 UNG_ECO45 - Uracil-DNA glycosylase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=ung PE=3 SV=1 UNG_ECO24 - Uracil-DNA glycosylase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=ung PE=3 SV=1 gi\|83570817, gi\|... - gi\|83570817\|ref\|ZP_00922260.1\| COG0692: Uracil DNA glycosylase [Shigella dysenteriae 1012], gi\|19443... UNG_ECOUT - Uracil-DNA glycosylase OS=Escherichia coli (strain UTI89 / UPEC) GN=ung PE=3 SV=1 sp\|B7UH19\|UNG_ECO27 - Uracil-DNA glycosylase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=ung PE=3 SV=1 gi\|226901456, gi... - gi\|237705090\|ref\|ZP_04535571.1\| uracil-DNA-glycosylase [Escherichia sp. 3_2_53FAA], gi\|226901456\|gb\|... gi\|227835966, gi... - gi\|227887616\|ref\|ZP_04005421.1\| uracil-DNA glycosylase [Escherichia coli 83972], gi\|227835966\|gb\|EEJ...	404.0	[0..1]	[229..1]
UNG_SHIF8 - Uracil-DNA glycosylase OS=Shigella flexneri serotype 5b (strain 8401) GN=ung PE=3 SV=1 gi\|30042237, gi\|... - gi\|30063981\|ref\|NP_838152.1\| uracil-DNA glycosylase [Shigella flexneri 2a str. 2457T], gi\|30042237\|g...	404.0	[0..1]	[229..1]
gi\|193068327, gi... - gi\|75237674\|ref\|ZP_00721690.1\| COG0692: Uracil DNA glycosylase [Escherichia coli E110019], gi\|193068...	403.0	[0..1]	[229..1]
UNG_ECO7I - Uracil-DNA glycosylase OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=ung PE=3 SV=1 gi\|190905699, gi... - gi\|75237401\|ref\|ZP_00721436.1\| COG0692: Uracil DNA glycosylase [Escherichia coli F11], gi\|191174008\|... UNG_ECOL5 - Uracil-DNA glycosylase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=ung PE=3 SV=1	403.0	[0..1]	[229..1]
UNG_ECOL6 - Uracil-DNA glycosylase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=ung PE=3 SV... UNG_ECOL6 - Uracil-DNA glycosylase OS=Escherichia coli O6 GN=ung PE=3 SV=3	402.0	[0..1]	[228..1]
gi\|26109352, gi\|... - gi\|26248946\|ref\|NP_754986.1\| uracil-DNA glycosylase [Escherichia coli CFT073], gi\|26109352\|gb\|AAN815...	402.0	[0..1]	[228..1]
gi\|5822576, gi\|5... - gi\|5822576\|pdb\|5EUG\|A Chain A, Crystallographic And Enzymatic Studies Of An Active Site Variant H187... gi\|5822568\|pdb\|4... - Chain A, Crystallographic And Enzymatic Studies Of An Active Site Variant H187q Of Escherichia Coli ...	402.0	[0..1]	[229..1]

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Predicted Domain #1

Region A:
Residues: [1-229]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANELTWHDV LAEEKQQPYF LNTLQTVASE RQSGVTIYPP QKDVFNAFRF TELGDVKVVI  60
   61 LGQDPYHGPG QAHGLAFSVR PGIAIPPSLL NMYKELENTI PGFTRPNHGY LESWARQGVL 120
  121 LLNTVLTVRA GQAHSHASLG WETFTDKVIS LINQHREGVV FLLWGSHAQK KGAIIDKQRH 180
  181 HVLKAPHPSP LSAHRGFFGC NHFVLANQWL EQRGETPIDW MPVLPAESE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	114.0
Match:	1eugA
Description:	Uracil-DNA glycosylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA N-glycosylase activity	4.32235853064174	bayes_pls_golite062009
uracil DNA N-glycosylase activity	4.14707882788321	bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds	3.89636585289546	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	2.84444466513934	bayes_pls_golite062009
hydrolase activity	1.91716804176625	bayes_pls_golite062009
single-strand selective uracil DNA N-glycosylase activity	1.65657095637032	bayes_pls_golite062009
catalytic activity	1.59111295908728	bayes_pls_golite062009
mismatch base pair DNA N-glycosylase activity	0.783383667044285	bayes_pls_golite062009
binding	0.587736812286194	bayes_pls_golite062009
structure-specific DNA binding	0.381118322219236	bayes_pls_golite062009
protein binding	0.272261244770552	bayes_pls_golite062009
nucleic acid binding	0.0311777202379154	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: