YRC Public Data Repository - Protein Structure Prediction

Protein:	PYRC_ECOLI
Organism:	Escherichia coli
Length:	348 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PYRC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|73536332, gi\|... - gi\|73536334\|pdb\|1XRT\|B Chain B, The Crystal Structure Of A Novel, Latent Dihydroorotase From Aquifex...	308.0	[0..1]	[346..90]
PYRC_AQUAE - Dihydroorotase OS=Aquifex aeolicus GN=pyrC PE=1 SV=1 PYRC_AQUAE - Dihydroorotase OS=Aquifex aeolicus (strain VF5) GN=pyrC PE=1 SV=1	308.0	[0..1]	[346..45]
PYRC_THEPX - Dihydroorotase OS=Thermoanaerobacter sp. (strain X514) GN=pyrC PE=3 SV=1 PYRC_THEP3 - Dihydroorotase OS=Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) GN=pyrC PE=3 SV=1 gi\|242232072, gi... - gi\|242256367\|ref\|ZP_04801259.1\| dihydroorotase, multifunctional complex type [Thermoanaerobacter sp.... gi\|241883211, gi... - gi\|241904422\|ref\|ZP_04789119.1\| dihydroorotase, multifunctional complex type [Thermoanaerobacter bro...	298.0	[0..2]	[346..44]
PYRC_CALS4 - Dihydroorotase OS=Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 /... PYRC_THETN - Dihydroorotase OS=Thermoanaerobacter tengcongensis GN=pyrC PE=3 SV=1	296.0	[0..2]	[347..44]
gi\|196253633, gi... - gi\|196253633\|ref\|ZP_03152251.1\| dihydroorotase, multifunctional complex type [Clostridium thermocell... gi\|67876353, gi\|... - gi\|67876353\|ref\|ZP_00505240.1\| Dihydroorotase multifunctional complex type [Clostridium thermocellum...	294.0	[0..1]	[346..44]
gi\|89210242, gi\|... - gi\|89210242\|ref\|ZP_01188633.1\| Dihydroorotase multifunctional complex type [Halothermothrix orenii H...	294.0	[0..2]	[346..46]
PYRC_CALS8 - Dihydroorotase OS=Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331) GN...	293.0	[0..1]	[338..45]
gi\|94428448, gi\|... - gi\|94499694\|ref\|ZP_01306231.1\| dihydroorotase [Oceanobacter sp. RED65], gi\|94428448\|gb\|EAT13421.1\| d...	291.0	[0..8]	[347..5]
PYRC_STAEQ - Dihydroorotase OS=Staphylococcus epidermidis (strain ATCC 35984 / RP62A) GN=pyrC PE=3 SV=1 gi\|242234057, gi... - gi\|242242483\|ref\|ZP_04796928.1\| dihydroorotase [Staphylococcus epidermidis W23144], gi\|242234057\|gb\|...	291.0	[0..2]	[343..44]
PYRC_CUPNH - Dihydroorotase OS=Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) GN=pyrC PE=3...	290.0	[0..5]	[347..2]

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Predicted Domain #1

Region A:
Residues: [1-348]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAPSQVLKI RRPDDWHLHL RDGDMLKTVV PYTSEIYGRA IVMPNLAPPV TTVEAAVAYR  60
   61 QRILDAVPAG HDFTPLMTCY LTDSLDPNEL ERGFNEGVFT AAKLYPANAT TNSSHGVTSI 120
  121 DAIMPVLERM EKIGMPLLVH GEVTHADIDI FDREARFIES VMEPLRQRLT ALKVVFEHIT 180
  181 TKDAADYVRD GNERLAATIT PQHLMFNRNH MLVGGVRPHL YCLPILKRNI HQQALRELVA 240
  241 SGFNRVFLGT DSAPHARHRK ESSCGCAGCF NAPTALGSYA TVFEEMNALQ HFEAFCSVNG 300
  301 PQFYGLPVND TFIELVREEQ QVAESIALTD DTLVPFLAGE TVRWSVKQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	76.0
Match:	1xgeA
Description:	Dihydroorotase from Escherichia coli: Loop Movement and Cooperativity between subunits
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydroorotase activity	2.32070383330692	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	2.20489529944693	bayes_pls_golite062009
deaminase activity	1.79186203771221	bayes_pls_golite062009
catalytic activity	1.70199291046899	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1.60895003474033	bayes_pls_golite062009
nucleic acid binding	0.629962267754185	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.573107361273483	bayes_pls_golite062009
transcription regulator activity	0.506159010274668	bayes_pls_golite062009
DNA binding	0.462348875991261	bayes_pls_golite062009
binding	0.459041534336076	bayes_pls_golite062009
hydrolase activity	0.24275130580417	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: