YRC Public Data Repository - Protein Structure Prediction

Protein:	PTNAB_ECOLI
Organism:	Escherichia coli
Length:	323 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTNAB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|77633668, gi\|... - gi\|77633668\|ref\|ZP_00795789.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos... gi\|149292704, gi... - gi\|149366291\|ref\|ZP_01888326.1\| PTS system, mannose-specific IIAB component [Yersinia pestis CA88-41... gi\|165938794, gi... - gi\|89104609\|ref\|ZP_01177148.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos... gi\|145210348, gi... - gi\|145598652\|ref\|YP_001162728.1\| PTS system, mannose-specific IIAB component [Yersinia pestis Pestoi... gi\|108807126, gi... - gi\|108807126\|ref\|YP_651042.1\| PTS system, mannose-specific IIAB component [Yersinia pestis Antiqua],... gi\|229902909, gi... - gi\|229902909\|ref\|ZP_04518026.1\| mannose-specific PTS enzyme [Yersinia pestis Nepal516], gi\|229680356... gi\|25287843 - pir\|\|AE0214 protein-Npi-phosphohistidine-sugar phosphotransferase (EC 2.7.1.69) IIAB component [impo... gi\|51595970, gi\|... - gi\|51595970\|ref\|YP_070161.1\| PTS system, mannose-specific IIAB component [Yersinia pseudotuberculosi... gi\|22126432, gi\|... - gi\|22126432\|ref\|NP_669855.1\| PTS system, mannose-specific IIAB component [Yersinia pestis KIM], gi\|2... gi\|166210521, gi... - gi\|166210521\|ref\|ZP_02236556.1\| PTS system, mannose/fructose/sorbose family, IIB component [Yersinia... gi\|15979785, gi\|... - gi\|218928882\|ref\|YP_002346757.1\| PTS system, mannose-specific IIAB component [Yersinia pestis CO92],... gi\|166010853, gi... - gi\|166010853\|ref\|ZP_02231751.1\| PTS system, mannose/fructose/sorbose family, IIB component [Yersinia... gi\|166961879, gi... - gi\|167420184\|ref\|ZP_02311937.1\| PTS system, mannose/fructose/sorbose family, IIB component [Yersinia... gi\|167402186, gi... - gi\|167402186\|ref\|ZP_02307661.1\| PTS system, mannose/fructose/sorbose family, IIB component [Yersinia... gi\|170024689, gi... - gi\|170024689\|ref\|YP_001721194.1\| PTS system mannose/fructose/sorbose family IIB subunit [Yersinia ps... gi\|167425847, gi... - gi\|167425847\|ref\|ZP_02317600.1\| PTS system, mannose/fructose/sorbose family, IIB component [Yersinia... gi\|186895069, gi... - gi\|186895069\|ref\|YP_001872181.1\| PTS system mannose/fructose/sorbose family IIB subunit [Yersinia ps... gi\|229896196, gi... - gi\|229896196\|ref\|ZP_04511366.1\| mannose-specific PTS enzyme [Yersinia pestis Pestoides A], gi\|229701... gi\|229693469, gi... - gi\|229897132\|ref\|ZP_04512288.1\| mannose-specific PTS enzyme [Yersinia pestis biovar Orientalis str. ... Q66BY2\|Q66BY2_YERPS - PTS system, mannose-specific IIAB component - Yersinia pseudotuberculosis gi\|229897859, gi... - gi\|229897859\|ref\|ZP_04513010.1\| mannose-specific PTS enzyme [Yersinia pestis biovar Orientalis str. ... gi\|165920046, gi... - gi\|165927989\|ref\|ZP_02223821.1\| PTS system, mannose/fructose/sorbose family, IIB component [Yersinia...	348.0	[0..1]	[323..1]
gi\|153950698, gi... - gi\|77628834\|ref\|ZP_00791420.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos...	347.0	[0..1]	[323..1]
gi\|75241314, gi\|... - gi\|75241314\|ref\|ZP_00725165.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos... gi\|110641934, gi... - gi\|110641934\|ref\|YP_669664.1\| PTS system, mannose-specific IIAB component [Escherichia coli 536], gi...	344.0	[0..1]	[323..1]
gi\|238728898, gi... - gi\|77980062\|ref\|ZP_00835477.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos...	343.0	[0..1]	[323..1]
gi\|218365448, gi... - gi\|218558679\|ref\|YP_002391592.1\| fused mannose-specific PTS enzymes: IIA component ; IIB component [... gi\|115513100, gi... - gi\|117623976\|ref\|YP_852889.1\| PTS system, mannose-specific IIAB component [Escherichia coli APEC O1]... gi\|237705767, gi... - gi\|237705767\|ref\|ZP_04536248.1\| PTS system [Escherichia sp. 3_2_53FAA], gi\|226900524\|gb\|EEH86783.1\| ... gi\|91072609, gi\|... - gi\|91211035\|ref\|YP_541021.1\| PTS system, mannose-specific IIAB component [Escherichia coli UTI89], g...	342.0	[0..1]	[323..1]
gi\|12515860, gi\|... - gi\|15802230\|ref\|NP_288253.1\| PTS system, mannose-specific IIAB component [Escherichia coli O157:H7 E... gi\|25287830 - gi\|25287830\|pir\|\|B85793 PTS enzyme IIAB, mannose-specific [imported] - Escherichia coli (strain O157...	339.0	[0..1]	[323..1]
gi\|77972312, gi\|... - gi\|77972312\|ref\|ZP_00827882.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos...	338.0	[0..1]	[323..1]
gi\|81241354, gi\|... - gi\|82777206\|ref\|YP_403555.1\| PTS enzyme IIAB, mannose-specific [Shigella dysenteriae Sd197], gi\|8124...	338.0	[0..1]	[322..1]
gi\|77959077, gi\|... - gi\|77959077\|ref\|ZP_00823100.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos...	337.0	[0..1]	[323..1]
gi\|197261643, gi... - gi\|197261643\|ref\|ZP_03161717.1\| PTS system, mannose-specific IIAB component [Salmonella enterica sub... lcl\|NC_016856.1_... - [gene=manX] [protein=mannose-specific enzyme IIAB] [protein_id=YP_005237771.1] [location=1939938..19... gi\|197093654, gi... - gi\|197362177\|ref\|YP_002141814.1\| PTS system, mannose-specific IIAB component [Salmonella enterica su... gi\|194405321, gi... - gi\|194446658\|ref\|YP_002041086.1\| PTS system, mannose-specific IIAB component [Salmonella enterica su... gi\|194448000, gi... - gi\|194448000\|ref\|YP_002045876.1\| PTS system, mannose-specific IIAB component [Salmonella enterica su... gi\|16420362, gi\|... - gi\|16765171\|ref\|NP_460786.1\| mannose-specific enzyme IIAB [Salmonella typhimurium LT2], gi\|16420362\|... gi\|168241424, gi... - gi\|205339563\|gb\|EDZ26327.1\| PTS system, mannose-specific IIAB component [Salmonella enterica subsp. ... gi\|205350893, gi... - gi\|205350893\|gb\|EDZ37524.1\| PTS system, mannose-specific IIAB component [Salmonella enterica subsp. ... gi\|167553488, gi... - gi\|205322074\|gb\|EDZ09913.1\| PTS system, mannose-specific IIAB component [Salmonella enterica subsp. ... gi\|224583679, gi... - gi\|224583679\|ref\|YP_002637477.1\| PTS system, mannose-specific IIAB component [Salmonella enterica su... gi\|56413251, gi\|... - gi\|56413251\|ref\|YP_150326.1\| PTS system, mannose-specific IIAB component [Salmonella enterica subsp....	335.0	[0..1]	[323..1]

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Predicted Domain #1

Region A:
Residues: [1-147]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIAIVIGTH GWAAEQLLKT AEMLLGEQEN VGWIDFVPGE NAETLIEKYN AQLAKLDTTK  60
   61 GVLFLVDTWG GSPFNAASRI VVDKEHYEVI AGVNIPMLVE TLMARDDDPS FDELVALAVE 120
  121 TGREGVKALK AKPVEKAAPA PAAAAPK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.0
Match:	1vrcA
Description:	Complex of enzyme IIAmannose and the histidine-containing phosphocarrier protein HPr from escherichia coli nmr, restrained regularized mean structure
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbohydrate transmembrane transporter activity	1.41958257592479	bayes_pls_golite062009
binding	1.3313872030407	bayes_pls_golite062009
protein binding	0.504276536503861	bayes_pls_golite062009
transporter activity	0.433212475678148	bayes_pls_golite062009
transmembrane transporter activity	0.21078048070603	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [148-323]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAPTPAKPMG PNDYMVIGLA RIDDRLIHGQ VATRWTKETN VSRIIVVSDE VAADTVRKTL  60
   61 LTQVAPPGVT AHVVDVAKMI RVYNNPKYAG ERVMLLFTNP TDVERLVEGG VKITSVNVGG 120
  121 MAFRQGKTQV NNAVSVDEKD IEAFKKLNAR GIELEVRKVS TDPKLKMMDL ISKIDK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	46.30103
Match:	1nrzA
Description:	Sorbose permease subunit IIb , EIIb-sor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbohydrate transmembrane transporter activity	3.89825676747483	bayes_pls_golite062009
transporter activity	2.00960396164678	bayes_pls_golite062009
transmembrane transporter activity	1.86135605657276	bayes_pls_golite062009
substrate-specific transporter activity	1.70618312780208	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.5973591090727	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.15285098263315	bayes_pls_golite062009
active transmembrane transporter activity	0.669347420921443	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.643818947881128	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: