YRC Public Data Repository - Protein Structure Prediction

Protein:	DDLB_ECOLI
Organism:	Escherichia coli
Length:	306 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DDLB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|109043037 - gi\|109043037\|ref\|XP_001096717.1\| PREDICTED: similar to methylcrotonoyl-Coenzyme A carboxylase 1 (alp...	313.0	[0..2]	[304..121]
gi\|77977550 - gi\|77977550\|ref\|ZP_00832995.1\| COG1181: D-alanine-D-alanine ligase and related ATP-grasp enzymes [Ye...	312.0	[0..1]	[306..1]
gi\|76670627 - gi\|76670627\|ref\|XP_591194.2\| PREDICTED: similar to methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) ...	311.0	[0..2]	[304..49]
gi\|114590613 - gi\|114590613\|ref\|XP_516898.2\| PREDICTED: methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) [Pan trogl...	310.0	[0..2]	[304..180]
gi\|77976098 - gi\|77976098\|ref\|ZP_00831631.1\| COG1181: D-alanine-D-alanine ligase and related ATP-grasp enzymes [Ye...	307.0	[0..1]	[306..1]
gi\|74003228 - gi\|74003228\|ref\|XP_535817.2\| PREDICTED: similar to methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) ...	307.0	[0..2]	[304..49]

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Predicted Domain #1

Region A:
Residues: [1-306]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDKIAVLLG GTSAEREVSL NSGAAVLAGL REGGIDAYPV DPKEVDVTQL KSMGFQKVFI  60
   61 ALHGRGGEDG TLQGMLELMG LPYTGSGVMA SALSMDKLRS KLLWQGAGLP VAPWVALTRA 120
  121 EFEKGLSDKQ LAEISALGLP VIVKPSREGS SVGMSKVVAE NALQDALRLA FQHDEEVLIE 180
  181 KWLSGPEFTV AILGEEILPS IRIQPSGTFY DYEAKYLSDE TQYFCPAGLE ASQEANLQAL 240
  241 VLKAWTTLGC KGWGRIDVML DSDGQFYLLE ANTSPGMTSH SLVPMAARQA GMSFSQLVVR 300
  301 ILELAD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	80.69897
Match:	1iovA
Description:	COMPLEX OF D-ALA:D-ALA LIGASE WITH ADP AND A PHOSPHORYL PHOSPHONATE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.87139587563481	bayes_pls_golite062009
D-alanine-D-alanine ligase activity	1.88295354007688	bayes_pls_golite062009
ligase activity	1.70071261805297	bayes_pls_golite062009
acid-amino acid ligase activity	1.43012336035246	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.463643664297841	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: