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View Structure Prediction Details

Protein: gfzf-PB, FBpp0306732
Organism: Drosophila melanogaster
Length: 1045 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gfzf-PB, FBpp0306732.

Description E-value Query
Range
Subject
Range
gi|31200375, gi|... - gi|31200375|ref|XP_309135.1| glutathione transferase (AGAP000947-PA) [Anopheles gambiae str. PEST], ...
gi|21541580 - gi|21541580|gb|AAM61888.1|AF515521_1 glutathione S-transferase u1; glutathione S-transferase I1 [Ano...
204.0 [0..812] [1039..1]

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Predicted Domain #1
Region A:
Residues: [1-116]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METPVEEHGM DLTKVSVVRS AKGVDMLCVD DYLYHFDRIG RNNTYRWLCN RRKDKSTPCK  60
   61 SRICTMLPDP LDKTRHVVVD VVLAHIHPRC SDHEVNKVAQ RKRLSVMMMN DAYSTT

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 7.102373
Match: PF04500.7
Description: No description for PF04500.7 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [117-261]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPKRARLYER ANAGMNPPEF IYGSIDTSTV EASFQLDFED KDRVYMLRRR DGRVMVCIDG  60
   61 HLYYLAGKSY KGDIFRWTCV RKRDIECTAR ICTEATLAGA HRLHAVDTDA HIHPHYSAAK 120
  121 LMHMFSKHQI VLVEDENTSD VLAEC

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 4.09691
Match: PF04500.7
Description: No description for PF04500.7 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [262-353]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNLEYFDPEN TFDTAQRGDD LESIIIEECE DNYDIYMRTD GSQGGGIQGS EELESQEGDD  60
   61 ESSLVDPKMH HSSKWPAAFD VIANYLPPPS HN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [354-463]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLTETDLTKF TFLPSAKGRK VLCLSQHLFH FDSQSRSNGH MFFTCINRRD KANTCHVRIT  60
   61 LDPVENGPVV LRINGEHTHN PDIKEIARRL KQQAKLDQDN VHKLQKIEHS 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 32.075721
Match: PF04500.7
Description: No description for PF04500.7 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [464-565]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEISFESDEG SASQGGDTFE AENSVDESYG HIDTRNVVMK KVISIDGAIK MEPESKANMI  60
   61 VQYLKDGANN ISAKIEILPD ALDELDPHSH TAYSSTPLPK VR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [566-727]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPQITNIRRR RDVAEPAKGA QPDMDLSKIC TLRSAKGHEL LCVDGYIYHA KNRGVISRNY  60
   61 WVCIKSRDPD INCKSRISTA TQKDGSIRVL RVYNSHSHPF SEDDIKRRLY NEINKKNNKN 120
  121 LKFRPLHFIG KSLDQIQQEY GDLAIERLNV SNISSDIVVH KK

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 32.79588
Match: PF04500.7
Description: No description for PF04500.7 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [728-809]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRVSGSNNSR SASLSVSHRA DSHHEEDDVV IVEEEYQEQE EGVEMTMEGD QQYMDVDNTD  60
   61 GIIEVVEEVA DEMESYGSIV PI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [810-1045]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTMKLYAVSD GPPSLAVRMT LKALDIQYQL INVDFCAMEH RSEEYSKMNP QKEIPVLDDD  60
   61 GFYLSESIAI MQYLCDKYAP DSTLYPQDVN VRAVINQRLC FNMGFYYAPI SAHSMAPIFF 120
  121 DYKRTPMSLK KVQNALDVFE TYLQRLGTKY AAGENITIAD FALISATICL EAINFDLHQF 180
  181 TLVNKWYETF KVEYPQLWEI ANSGMQEISA FEQNPPDMSH MEHPFHPTRK SMGLKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.045757
Match: 1pn9A
Description: Crystal structure of an insect delta-class glutathione S-transferase from a DDT-resistant strain of the malaria vector Anopheles gambiae
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
antioxidant activity 3.8464796631544 bayes_pls_golite062009
peroxidase activity 3.44705858438242 bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor 3.44705858438242 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 2.23310780102446 bayes_pls_golite062009
peroxiredoxin activity 2.12777217096121 bayes_pls_golite062009
glutathione peroxidase activity 2.012364779649 bayes_pls_golite062009
thioredoxin peroxidase activity 1.96134566495756 bayes_pls_golite062009
glutathione transferase activity 1.85683051472829 bayes_pls_golite062009
oxidoreductase activity 1.71351657881838 bayes_pls_golite062009
disulfide oxidoreductase activity 1.32811008894503 bayes_pls_golite062009
glutathione binding 1.1614557144978 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
binding 0.274799360132997 bayes_pls_golite062009
protein disulfide oxidoreductase activity 0.0719543694089202 bayes_pls_golite062009
receptor binding 0.0226227421058591 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle