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View Structure Prediction Details

Protein: nhr-35
Organism: Caenorhabditis elegans
Length: 486 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-35.

Description E-value Query
Range
Subject
Range
gi|38147338 - gi|38147338|gb|AAR11981.1| nuclear receptor NHR-35 [Caenorhabditis elegans]
327.0 [0..1] [486..2]

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Predicted Domain #1
Region A:
Residues: [1-115]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLGTYNGDSK AETDGKDNSI CHICSDVATG RHYGAIACNG CKGFFRRTVR RNYEYHCRFE  60
   61 SKCEIDKHNR AVCRYCRFMK CISSGMRDDQ VQSERDVIGK REKKDNMKTY CQDPT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.30103
Match: 2hanB
Description: No description for 2hanB was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
nucleic acid binding 3.47256374293954 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription activator activity 2.9532663930699 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
sequence-specific DNA binding 2.72967350701574 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.55186574506963 bayes_pls_golite062009
protein binding 2.44501340584871 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.40923942043513 bayes_pls_golite062009
ion transmembrane transporter activity 2.00119042792567 bayes_pls_golite062009
nuclear hormone receptor binding 1.91348392022358 bayes_pls_golite062009
transcription repressor activity 1.88834375049208 bayes_pls_golite062009
hormone receptor binding 1.8288193687002 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.81056798510499 bayes_pls_golite062009
steroid hormone receptor binding 1.72196998170947 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
androgen receptor binding 1.48596869620742 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
steroid hormone receptor activity 1.28090460550476 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.26452462867497 bayes_pls_golite062009
structural constituent of ribosome 1.26313925559554 bayes_pls_golite062009
structural molecule activity 1.1947100233139 bayes_pls_golite062009
transporter activity 0.768214707487563 bayes_pls_golite062009
transcription coactivator activity 0.61572149323953 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
transmembrane transporter activity 0.50876329665586 bayes_pls_golite062009
receptor activity 0.230063209127305 bayes_pls_golite062009
substrate-specific transporter activity 0.187612502757984 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [116-382]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRTSPELTMS PVEDEYDQLL ESLLKSEMTI QSLRDTVITQ TGNVEYTTKS KNRLSHTDRT  60
   61 ATLNDVLKSM HSQLLLVIEW AKTLPEFKQL SGADQAVLLK NFAGQHVTLC VAYRSVGAND 120
  121 ALKLLNDLYI PRASKTTPHL KEYVDGFYLR DCEKVMDQLV EPMRFLKLDN KEFVALKACV 180
  181 LFNPVAPGLS NHAVNLVLNA RRKIFAAFEK YVRVNKPLET TRVGDLTFFI LTPLSVLSKS 240
  241 ISEDIMFTKV SGVARIDVLM EELILAE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.09691
Match: 1lbdA
Description: LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
vitamin D3 receptor activity 5.5563493713822 bayes_pls_golite062009
transcription regulator activity 5.53061626347066 bayes_pls_golite062009
ecdysteroid hormone receptor activity 5.24236817167929 bayes_pls_golite062009
DNA binding 4.92165988569962 bayes_pls_golite062009
steroid hormone receptor activity 4.81441024181511 bayes_pls_golite062009
nucleic acid binding 4.78024150262074 bayes_pls_golite062009
transcription activator activity 4.53302455129434 bayes_pls_golite062009
sequence-specific DNA binding 4.11614358606713 bayes_pls_golite062009
transcription factor activity 4.0914094580319 bayes_pls_golite062009
nuclear hormone receptor binding 3.91470119037087 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 3.89763470197726 bayes_pls_golite062009
binding 3.85318710398432 bayes_pls_golite062009
transcription repressor activity 3.83878598697109 bayes_pls_golite062009
hormone receptor binding 3.79647267365529 bayes_pls_golite062009
protein binding 3.21524787168952 bayes_pls_golite062009
transcription activator binding 2.98235973123409 bayes_pls_golite062009
transcription factor binding 2.68044489404568 bayes_pls_golite062009
receptor activity 2.62895787183554 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.38308182853979 bayes_pls_golite062009
transcription coactivator activity 2.27959329058894 bayes_pls_golite062009
vitamin D binding 2.05947211013242 bayes_pls_golite062009
signal transducer activity 2.04709877069886 bayes_pls_golite062009
molecular transducer activity 2.04709877069886 bayes_pls_golite062009
transcription cofactor activity 1.73827483890179 bayes_pls_golite062009
retinoic acid receptor binding 1.59968001933699 bayes_pls_golite062009
retinoid binding 1.57244905045132 bayes_pls_golite062009
structure-specific DNA binding 1.56146647486761 bayes_pls_golite062009
double-stranded DNA binding 1.48246587604476 bayes_pls_golite062009
estrogen receptor activity 1.47290778095383 bayes_pls_golite062009
isoprenoid binding 1.45798199211445 bayes_pls_golite062009
retinoid X receptor binding 1.45560845709347 bayes_pls_golite062009
juvenile hormone binding 1.35482717568148 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.34794228300778 bayes_pls_golite062009
promoter binding 1.28787959668198 bayes_pls_golite062009
palmitoyl-CoA hydrolase activity 1.23181585568439 bayes_pls_golite062009
transcription corepressor activity 0.995333369475571 bayes_pls_golite062009
retinoic acid receptor activity 0.853869057774515 bayes_pls_golite062009
protein dimerization activity 0.797229273848179 bayes_pls_golite062009
steroid hormone receptor binding 0.754240851368212 bayes_pls_golite062009
protein N-terminus binding 0.57701453824007 bayes_pls_golite062009
thyroid hormone receptor activity 0.49784404390361 bayes_pls_golite062009
lipid binding 0.475303782949439 bayes_pls_golite062009
protein heterodimerization activity 0.45265806678057 bayes_pls_golite062009
receptor binding 0.418843034756825 bayes_pls_golite062009
estrogen response element binding 0.26972535024334 bayes_pls_golite062009
ligand-regulated transcription factor activity 0.202197503742221 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.15737167800277 bayes_pls_golite062009
catalytic activity 0.106902059021677 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [383-486]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDYGEDRQDQ TPCSIMNDTP SGSQDMCSPC PEDLLRTSTS SNSPTNSSLT AGLLLKTDDA  60
   61 MMSGIGTQYT TPQPHTPQFA DSSHLNLPYA PFTSSYNQYP NTYS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle