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View Structure Prediction Details

Protein: gi|29501524
Organism: Plasmodium falciparum
Length: 545 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|29501524.

Description E-value Query
Range
Subject
Range
IMA1B_ORYSJ - Importin subunit alpha-1b OS=Oryza sativa subsp. japonica GN=Os05g0155601 PE=1 SV=2
IMA1B_ORYSA - Importin alpha-1b subunit - Oryza sativa (Rice)
369.0 [0..4] [544..8]
gi|84453224 - gi|84453224|dbj|BAE71209.1| putative importin alpha [Trifolium pratense]
363.0 [0..4] [545..10]
gi|2950210, gi|2... - gi|2950210|emb|CAA74965.1| Importin alpha-like protein [Arabidopsis thaliana], pir||T52098 probable ...
361.0 [0..3] [544..7]
gi|59800319, gi|... - gi|59800319|gb|AAX07453.1| karyopherin alpha 2 [Rattus norvegicus], gi|58477719|gb|AAH89787.1| Karyo...
356.0 [0..3] [544..8]

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Predicted Domain #1
Region A:
Residues: [1-545]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRRIEARRK EFKKNCDDTR RKREDLVVQI RKQQRECQLE SKRAMVMANI GFEENNTYNL  60
   61 NYAKGNQNDS TNDSIYNTSS NNSSNTLEML KKIPTLAIGV RSNEYVTQLN STRELRKLLS 120
  121 IEKGPPIQEV INSGVVPYIV EFLKYDDKTD LQFEAAWVIT NIASGSQEQT KVVIDNNAVP 180
  181 HLVRLLSSEK EDVCEQAVWA LGNIAGDSAE CREYVLNQNS LPLLLKILRT SHKRTLIRNA 240
  241 AWTLSNLCRG KPAPKFEIVS KALPTLAALI YNDDEEILTD ACWTLSYLSD GSNENINSVL 300
  301 DAGVAERVVE LLSHCSFLVQ TPALRTVGNI VTGDDLQTDV VVKLGAVQKL SCLLNSSKKS 360
  361 IKKEACWALS NITAGNISQI QAVIDNNVIP QLINILMKED FEVRKEAAWA ISNASSGGSE 420
  421 LQIEYLVECG AIHSLSNLLD VEDANIISVT LEGLENILEM GENKKLRDNL PTNPYVHLFE 480
  481 ECDSVHKIDA LQDRKVDNIC NKAWKILYKY FPFVINNELN NAQIPLNNVF ANTEDAVLNK 540
  541 DFTFD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 86.154902
Match: 1wa5B
Description: Crystal structure of the exportin Cse1p complexed with its cargo ( Kap60p) and RanGTP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 4.58709163830613 bayes_pls_golite062009
nuclear export signal receptor activity 3.48172991171337 bayes_pls_golite062009
binding 3.0667965351474 bayes_pls_golite062009
nucleic acid binding 2.74745843355294 bayes_pls_golite062009
protein transmembrane transporter activity 2.74547353635661 bayes_pls_golite062009
transporter activity 2.48700774379895 bayes_pls_golite062009
substrate-specific transporter activity 2.26725422172281 bayes_pls_golite062009
transcription regulator activity 2.16673352512615 bayes_pls_golite062009
DNA binding 1.95242774903625 bayes_pls_golite062009
actin binding 1.92303661041222 bayes_pls_golite062009
nuclear localization sequence binding 1.91487015967262 bayes_pls_golite062009
protein binding 1.73688475473996 bayes_pls_golite062009
cytoskeletal protein binding 1.71123825371014 bayes_pls_golite062009
molecular transducer activity 1.32874350341969 bayes_pls_golite062009
signal transducer activity 1.32874350341969 bayes_pls_golite062009
transmembrane transporter activity 1.28481004323799 bayes_pls_golite062009
transcription factor activity 1.20660383756339 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.09652988954158 bayes_pls_golite062009
signal sequence binding 0.57106697498903 bayes_pls_golite062009
RNA binding 0.40024158562931 bayes_pls_golite062009
structural molecule activity 0.279926218252647 bayes_pls_golite062009
importin-alpha export receptor activity 0.259676026705859 bayes_pls_golite062009
active transmembrane transporter activity 0.252495966234234 bayes_pls_golite062009
ion transmembrane transporter activity 0.248585912061178 bayes_pls_golite062009
primary active transmembrane transporter activity 0.226380819487924 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.217517113570989 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.178770060806735 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.175241020572885 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.174922130116569 bayes_pls_golite062009
transcription activator activity 0.160275383613705 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.100181463251306 bayes_pls_golite062009
pyrophosphatase activity 0.0635404099346928 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0548082069333885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.052195223119721 bayes_pls_golite062009
cation transmembrane transporter activity 0.0405268469927988 bayes_pls_golite062009
transcription factor binding 0.0221966060394205 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle