YRC Public Data Repository - Protein Structure Prediction

Protein:	NARZ_ECOLI
Organism:	Escherichia coli
Length:	1246 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NARZ_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|42108 - gi\|42108\|emb\|CAA34964.1\| narZ product [Escherichia coli]	1050.0	[0..1]	[1246..1]
gi\|157160944, gi... - gi\|75195571\|ref\|ZP_00705641.1\| COG5013: Nitrate reductase alpha subunit [Escherichia coli HS], gi\|15...	1049.0	[0..1]	[1246..1]
gi\|218351739, gi... - gi\|218695007\|ref\|YP_002402674.1\| nitrate reductase 2 (NRZ), alpha subunit [Escherichia coli 55989], ... gi\|190904782, gi... - gi\|75231778\|ref\|ZP_00718119.1\| COG5013: Nitrate reductase alpha subunit [Escherichia coli B7A], gi\|1...	1049.0	[0..1]	[1246..1]
gi\|110805707, gi... - gi\|110805707\|ref\|YP_689227.1\| cryptic nitrate reductase 2, alpha subunit [Shigella flexneri 5 str. 8...	1049.0	[0..1]	[1246..1]
gi\|193067020, gi... - gi\|75239911\|ref\|ZP_00723872.1\| COG5013: Nitrate reductase alpha subunit [Escherichia coli E110019], ...	1049.0	[0..1]	[1246..1]
gi\|188487833, gi... - gi\|75512578\|ref\|ZP_00735101.1\| COG5013: Nitrate reductase alpha subunit [Escherichia coli 53638], gi...	1048.0	[0..1]	[1246..1]
gi\|26108160, gi\|... - gi\|26247758\|ref\|NP_753798.1\| respiratory nitrate reductase 2 alpha chain [Escherichia coli CFT073], ...	1047.0	[0..1]	[1246..42]
gi\|192927538, gi... - gi\|75257133\|ref\|ZP_00728669.1\| COG5013: Nitrate reductase alpha subunit [Escherichia coli E22], gi\|1...	1047.0	[0..1]	[1246..1]
gi\|110343240, gi... - gi\|110641648\|ref\|YP_669378.1\| respiratory nitrate reductase 2 a chain [Escherichia coli 536], gi\|110... gi\|190906883, gi... - gi\|75240184\|ref\|ZP_00724136.1\| COG5013: Nitrate reductase alpha subunit [Escherichia coli F11], gi\|1...	1047.0	[0..1]	[1246..1]

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Predicted Domain #1

Region A:
Residues: [1-1246]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKLLDRFRY FKQKGETFAD GHGQVMHSNR DWEDSYRQRW QFDKIVRSTH GVNCTGSCSW  60
   61 KIYVKNGLVT WEIQQTDYPR TRPDLPNHEP RGCPRGASYS WYLYSANRLK YPLIRKRLIE 120
  121 LWREALKQHS DPVLAWASIM NDPQKCLSYK QVRGRGGFIR SNWQELNQLI AAANVWTIKT 180
  181 YGPDRVAGFS PIPAMSMVSY AAGTRYLSLL GGTCLSFYDW YCDLPPASPM TWGEQTDVPE 240
  241 SADWYNSSYI IAWGSNVPQT RTPDAHFFTE VRYKGTKTIA ITPDYSEVAK LCDQWLAPKQ 300
  301 GTDSALAMAM GHVILKEFHL DNPSDYFINY CRRYSDMPML VMLEPRDDGS YVPGRMIRAS 360
  361 DLVDGLGESN NPQWKTVAVN TAGELVVPNG SIGFRWGEKG KWNLESIAAG TETELSLTLL 420
  421 GQHDAVAGVA FPYFGGIENP HFRSVKHNPV LVRQLPVKNL TLVDGNTCPV VSVYDLVLAN 480
  481 YGLDRGLEDE NSAKDYAEIK PYTPAWGEQI TGVPRQYIET IAREFADTAH KTHGRSMIIL 540
  541 GAGVNHWYHM DMNYRGMINM LIFCGCVGQS GGGWAHYVGQ EKLRPQTGWL PLAFALDWNR 600
  601 PPRQMNSTSF FYNHSSQWRY EKVSAQELLS PLADASKYSG HLIDFNVRAE RMGWLPSAPQ 660
  661 LGRNPLGIKA EADKAGLSPT EFTAQALKSG DLRMACEQPD SSSNHPRNLF VWRSNLLGSS 720
  721 GKGHEYMQKY LLGTESGIQG EELGASDGIK PEEVEWQTAA IEGKLDLLVT LDFRMSSTCL 780
  781 FSDIVLPTAT WYEKDDMNTS DMHPFIHPLS AAVDPAWESR SDWEIYKGIA KAFSQVCVGH 840
  841 LGKETDVVLQ PLLHDSPAEL SQPCEVLDWR KGECDLIPGK TAPNIVAVER DYPATYERFT 900
  901 SLGPLMDKLG NGGKGISWNT QDEIDFLGKL NYTKRDGPAQ GRPLIDTAID ASEVILALAP 960
  961 ETNGHVAVKA WQALGEITGR EHTHLALHKE DEKIRFRDIQ AQPRKIISSP TWSGLESDHV1020
 1021 SYNAGYTNVH ELIPWRTLSG RQQLYQDHPW MRAFGESLVA YRPPIDTRSV SEMRQIPPNG1080
 1081 FPEKALNFLT PHQKWGIHST YSENLLMLTL SRGGPIVWIS ETDARELTIV DNDWVEVFNA1140
 1141 NGALTARAVV SQRVPPGMTM MYHAQERIMN IPGSEVTGMR GGIHNSVTRV CPKPTHMIGG1200
 1201 YAQLAWGFNY YGTVGSNRDE FIMIRKMKNV NWLDDEGRDQ VQEAKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1q16A
Description:	Crystal structure of Nitrate Reductase A, NarGHI, from Escherichia coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nitrate reductase activity	8.67207154808722	bayes_pls_golite062009
oxidoreductase activity, acting on other nitrogenous compounds as donors	7.49490418452899	bayes_pls_golite062009
formate dehydrogenase activity	6.68295624624715	bayes_pls_golite062009
oxidoreductase activity	2.91217637289036	bayes_pls_golite062009
catalytic activity	1.93875927205186	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	1.84836110501265	bayes_pls_golite062009
trimethylamine-N-oxide reductase activity	1.53833487723248	bayes_pls_golite062009
4 iron, 4 sulfur cluster binding	1.49405789941498	bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity	1.23004970625774	bayes_pls_golite062009
molybdenum ion binding	1.06869099200697	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	0.968773059107375	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.953913424085709	bayes_pls_golite062009
binding	0.91711075983007	bayes_pls_golite062009
NADH dehydrogenase activity	0.885018100222005	bayes_pls_golite062009
electron carrier activity	0.662243065357708	bayes_pls_golite062009
NADH dehydrogenase (quinone) activity	0.580090675196619	bayes_pls_golite062009
iron-sulfur cluster binding	0.552726587326143	bayes_pls_golite062009
metal cluster binding	0.552726587326143	bayes_pls_golite062009
protein binding	0.435238397559303	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	0.136519634312491	bayes_pls_golite062009
aspartate 1-decarboxylase activity	0.00734160407262602	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: