YRC Public Data Repository - Protein Structure Prediction

Protein:	TRPG_ECOLI
Organism:	Escherichia coli
Length:	531 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRPG_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|147920704, gi... - gi\|147920704\|ref\|YP_685492.1\| anthranilate synthase, component II (including glutamine amidotransfer...	511.0	[0..3]	[528..2]
gi\|237705287, gi... - gi\|237705287\|ref\|ZP_04535768.1\| anthranilate synthase component II [Escherichia sp. 3_2_53FAA], gi\|2... gi\|26247592, gi\|... - gi\|26247592\|ref\|NP_753632.1\| bifunctional anthranilate synthase/anthranilate phosphoribosyltransfera... gi\|227886308, gi... - gi\|227886308\|ref\|ZP_04004113.1\| bifunctional anthranilate synthase/anthranilate phosphoribosyltransf... gi\|117623524, gi... - gi\|117623524\|ref\|YP_852437.1\| bifunctional anthranilate synthase/anthranilate phosphoribosyltransfer... gi\|218365017, gi... - gi\|218558248\|ref\|YP_002391161.1\| bifunctional glutamine amidotransferase/anthranilate phosphoribosyl... gi\|218699970, gi... - gi\|218699970\|ref\|YP_002407599.1\| bifunctional glutamine amidotransferase/anthranilate phosphoribosyl... gi\|170517416, gi... - gi\|170679698\|ref\|YP_001743923.1\| anthranilate synthase, component II [Escherichia coli SMS-3-5], gi\|... gi\|218549046, gi... - gi\|218549046\|ref\|YP_002382837.1\| bifunctional glutamine amidotransferase/anthranilate phosphoribosyl... gi\|91072129, gi\|... - gi\|91210555\|ref\|YP_540541.1\| bifunctional anthranilate synthase/anthranilate phosphoribosyltransfera...	483.0	[0..1]	[531..1]
gi\|187428851, gi... - gi\|75179092\|ref\|ZP_00699110.1\| COG0547: Anthranilate phosphoribosyltransferase [Shigella boydii BS51... gi\|82544283, gi\|... - gi\|82544283\|ref\|YP_408230.1\| bifunctional anthranilate synthase/anthranilate phosphoribosyltransfera...	483.0	[0..1]	[531..1]
gi\|191170937, gi... - gi\|75242063\|ref\|ZP_00725857.1\| COG0547: Anthranilate phosphoribosyltransferase [Escherichia coli F11... gi\|110641493, gi... - gi\|110641493\|ref\|YP_669223.1\| bifunctional glutamine amidotransferase/anthranilate phosphoribosyltra...	483.0	[0..1]	[531..1]
gi\|74312367, gi\|... - gi\|74312367\|ref\|YP_310786.1\| bifunctional anthranilate synthase/anthranilate phosphoribosyltransfera...	482.0	[0..1]	[531..1]
gi\|43194, gi\|432... - gi\|43203\|emb\|CAA23672.1\| unnamed protein product [Escherichia coli], gi\|43194\|emb\|CAA23665.1\| unname...	482.0	[0..1]	[531..1]
gi\|30041034, gi\|... - gi\|30062786\|ref\|NP_836957.1\| bifunctional anthranilate synthase/anthranilate phosphoribosyltransfera... gi\|24112662, gi\|... - gi\|24112662\|ref\|NP_707172.1\| bifunctional anthranilate synthase/anthranilate phosphoribosyltransfera...	482.0	[0..1]	[531..1]
gi\|82776620, gi\|... - gi\|82776620\|ref\|YP_402969.1\| bifunctional anthranilate synthase/anthranilate phosphoribosyltransfera...	481.0	[0..1]	[531..1]
gi\|208816177, gi... - gi\|208816177\|ref\|ZP_03257356.1\| anthranilate synthase, component II [Escherichia coli O157:H7 str. E... gi\|208741263, gi... - gi\|208821140\|ref\|ZP_03261460.1\| anthranilate synthase, component II [Escherichia coli O157:H7 str. E... gi\|209397663, gi... - gi\|209397663\|ref\|YP_002270318.1\| anthranilate synthase, component II [Escherichia coli O157:H7 str. ... gi\|217329280, gi... - gi\|217329280\|ref\|ZP_03445360.1\| anthranilate synthase, component II [Escherichia coli O157:H7 str. T... gi\|168783766, gi... - gi\|188998928\|gb\|EDU67914.1\| anthranilate synthase, component II [Escherichia coli O157:H7 str. EC407... gi\|189376279, gi... - gi\|189376279\|gb\|EDU94695.1\| anthranilate synthase, component II [Escherichia coli O157:H7 str. EC508... gi\|195939197 - gi\|195939197\|ref\|ZP_03084579.1\| bifunctional anthranilate synthase/anthranilate phosphoribosyltransf... gi\|208810909, gi... - gi\|208810909\|ref\|ZP_03252742.1\| anthranilate synthase, component II [Escherichia coli O157:H7 str. E... gi\|189354837, gi... - gi\|189354837\|gb\|EDU73256.1\| anthranilate synthase, component II [Escherichia coli O157:H7 str. EC440... gi\|168763589, gi... - gi\|189366238\|gb\|EDU84654.1\| anthranilate synthase, component II [Escherichia coli O157:H7 str. EC450... gi\|168771262, gi... - gi\|189359958\|gb\|EDU78377.1\| anthranilate synthase, component II [Escherichia coli O157:H7 str. EC448... gi\|168775072, gi... - gi\|187769321\|gb\|EDU33165.1\| anthranilate synthase, component II [Escherichia coli O157:H7 str. EC419... gi\|254792852, gi... - gi\|254792852\|ref\|YP_003077689.1\| fused glutamine amidotransferase (component II) of anthranilate syn... gi\|188014790, gi... - gi\|188014790\|gb\|EDU52912.1\| anthranilate synthase, component II [Escherichia coli O157:H7 str. EC411... gi\|13361300, gi\|... - gi\|15831089\|ref\|NP_309862.1\| bifunctional glutamine amidotransferase/anthranilate phosphoribosyltran... gi\|209772072, gi... - pir\|\|C90858 anthranilate synthase component II [imported] - Escherichia coli (strain O157:H7, substr... gi\|13361300, gi\|... - gi\|15831089\|ref\|NP_309862.1\| anthranilate phosphoribosyltransferase [Escherichia coli O157:H7], gi\|1...	481.0	[0..1]	[531..1]
gi\|25291383 - pir\|\|E85761 hypothetical protein trpD [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|15801915, gi\|... - gi\|15801915\|ref\|NP_287936.1\| bifunctional anthranilate synthase/anthranilate phosphoribosyltransfera...	480.0	[0..1]	[531..1]

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Predicted Domain #1

Region A:
Residues: [1-195]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADILLLDNI DSFTYNLADQ LRSNGHNVVI YRNHIPAQTL IERLATMSNP VLMLSPGPGV  60
   61 PSEAGCMPEL LTRLRGKLPI IGICLGHQAI VEAYGGYVGQ AGEILHGKAS SIEHDGQAMF 120
  121 AGLTNPLPVA RYHSLVGSNI PAGLTINAHF NGMVMAVRHD ADRVCGFQFH PESILTTQGA 180
  181 RLLEQTLAWA QQKLE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.09691
Match:	1i1qB
Description:	Anthranilate synthase GAT subunit, TrpG
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
4-amino-4-deoxychorismate synthase activity	4.48164623771604	bayes_pls_golite062009
anthranilate synthase activity	2.51214170411838	bayes_pls_golite062009
ligase activity	1.77692713123297	bayes_pls_golite062009
oxo-acid-lyase activity	1.35896725827905	bayes_pls_golite062009
catalytic activity	1.30391542469987	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.628648036096965	bayes_pls_golite062009
imidazoleglycerol-phosphate synthase activity	0.270391651600004	bayes_pls_golite062009
carbon-carbon lyase activity	0.0769356405014503	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [196-531]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PANTLQPILE KLYQAQTLSQ QESHQLFSAV VRGELKPEQL AAALVSMKIR GEHPNEIAGA  60
   61 ATALLENAAP FPRPDYLFAD IVGTGGDGSN SINISTASAF VAAACGLKVA KHGNRSVSSK 120
  121 SGSSDLLAAF GINLDMNADK SRQALDELGV CFLFAPKYHT GFRHAMPVRQ QLKTRTLFNV 180
  181 LGPLINPAHP PLALIGVYSP ELVLPIAETL RVLGYQRAAV VHSGGMDEVS LHAPTIVAEL 240
  241 HDGEIKSYQL TAEDFGLTPY HQEQLAGGTP EENRDILTRL LQGKGDAAHE AAVAANVAML 300
  301 MRLHGHEDLQ ANAQTVLEVL RSGSAYDRVT ALAARG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	90.69897
Match:	1kgzA
Description:	Anthranilate phosphoribosyltransferase (TrpD)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
anthranilate phosphoribosyltransferase activity	4.81240054558791	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	2.10935430322097	bayes_pls_golite062009
catalytic activity	1.99182579317454	bayes_pls_golite062009
transferase activity	1.24273940197065	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	1.10712828233974	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: