YRC Public Data Repository - Protein Structure Prediction

Protein:	OTC2_ECOLI
Organism:	Escherichia coli
Length:	334 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OTC2_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|238715532, gi... - gi\|77956490\|ref\|ZP_00820584.1\| COG0078: Ornithine carbamoyltransferase [Yersinia bercovieri ATCC 439...	461.0	[0..1]	[334..7]
gi\|21957461, gi\|... - gi\|22124653\|ref\|NP_668076.1\| ornithine carbamoyltransferase subunit I [Yersinia pestis KIM], gi\|2195... gi\|229695459, gi... - gi\|229839093\|ref\|ZP_04459252.1\| ornithine carbamoyltransferase chain I [Yersinia pestis biovar Orien... gi\|16123594, gi\|... - gi\|218930462\|ref\|YP_002348337.1\| ornithine carbamoyltransferase subunit I [Yersinia pestis CO92], gi... gi\|45440490, gi\|... - gi\|45440490\|ref\|NP_992029.1\| ornithine carbamoyltransferase subunit I [Yersinia pestis biovar Microt... gi\|153997512, gi... - gi\|153997512\|ref\|ZP_02022612.1\| ornithine carbamoyltransferase chain I [Yersinia pestis CA88-4125], ... gi\|165922267, gi... - gi\|165925655\|ref\|ZP_02221487.1\| ornithine carbamoyltransferase [Yersinia pestis biovar Orientalis st... gi\|165990984, gi... - gi\|166010077\|ref\|ZP_02230975.1\| ornithine carbamoyltransferase [Yersinia pestis biovar Antiqua str. ... gi\|166204511, gi... - gi\|166214279\|ref\|ZP_02240314.1\| ornithine carbamoyltransferase [Yersinia pestis biovar Antiqua str. ... OTC_YERPE - Ornithine carbamoyltransferase OS=Yersinia pestis GN=argI PE=3 SV=1 OTC_YERPP - Ornithine carbamoyltransferase OS=Yersinia pestis (strain Pestoides F) GN=argI PE=3 SV=1 gi\|167399180, gi... - gi\|167399180\|ref\|ZP_02304704.1\| ornithine carbamoyltransferase [Yersinia pestis biovar Antiqua str. ... gi\|167420763, gi... - gi\|167420763\|ref\|ZP_02312516.1\| ornithine carbamoyltransferase [Yersinia pestis biovar Orientalis st... gi\|167057484, gi... - gi\|167423314\|ref\|ZP_02315067.1\| ornithine carbamoyltransferase [Yersinia pestis biovar Mediaevalis s... gi\|162421195, gi... - gi\|77634905\|ref\|ZP_00796997.1\| COG0078: Ornithine carbamoyltransferase [Yersinia pestis Angola], gi\|... gi\|89101649, gi\|... - gi\|89101649\|ref\|ZP_01174364.1\| COG0078: Ornithine carbamoyltransferase [Yersinia pestis biovar Orien... OTC_YERPN - Ornithine carbamoyltransferase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=argI PE=3 SV=1 gi\|229687148, gi... - gi\|229899656\|ref\|ZP_04514797.1\| ornithine carbamoyltransferase chain I [Yersinia pestis biovar Orien... gi\|229700359, gi... - gi\|229896581\|ref\|ZP_04511748.1\| ornithine carbamoyltransferase chain I [Yersinia pestis Pestoides A]...	460.0	[0..1]	[334..1]
gi\|238727655, gi... - gi\|77978585\|ref\|ZP_00834012.1\| COG0078: Ornithine carbamoyltransferase [Yersinia intermedia ATCC 299...	458.0	[0..1]	[334..1]
OTC_YERP3 - Ornithine carbamoyltransferase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=arg...	457.0	[0..1]	[334..1]
gi\|186893888, gi... - gi\|186893888\|ref\|YP_001871000.1\| ornithine carbamoyltransferase subunit I [Yersinia pseudotuberculos... OTC_YERPS - Ornithine carbamoyltransferase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=argI PE... OTC_YERPS - Ornithine carbamoyltransferase OS=Yersinia pseudotuberculosis GN=argI PE=3 SV=1	457.0	[0..1]	[334..1]
gi\|77960004 - gi\|77960004\|ref\|ZP_00823908.1\| COG0078: Ornithine carbamoyltransferase [Yersinia mollaretii ATCC 439...	455.0	[0..1]	[334..7]
OTC_PECAS - Ornithine carbamoyltransferase OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) GN=a... OTC_ERWCT - Ornithine carbamoyltransferase OS=Erwinia carotovora subsp. atroseptica GN=argI PE=3 SV=1	451.0	[0..1]	[334..1]
gi\|83586721, gi\|... - gi\|83586721\|ref\|ZP_00925353.1\| COG0078: Ornithine carbamoyltransferase [Escherichia coli 101-1], gi\|...	451.0	[0..1]	[334..1]
OTC_ECO24 - Ornithine carbamoyltransferase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=argI PE=3 SV=...	451.0	[0..1]	[334..1]
OTC_ECO57 - Ornithine carbamoyltransferase OS=Escherichia coli O157:H7 GN=argI PE=3 SV=3 gi\|25286273, gi\|... - pir\|\|A86124 ornithine carbamoyltransferase 1 [imported] - Escherichia coli (strain O157:H7, substrai... gi\|15804846, gi\|... - gi\|15804846\|ref\|NP_290887.1\| ornithine carbamoyltransferase subunit I [Escherichia coli O157:H7 EDL9... gi\|208739534, gi... - gi\|208819411\|ref\|ZP_03259731.1\| ornithine carbamoyltransferase [Escherichia coli O157:H7 str. EC4042... gi\|209398427, gi... - gi\|209398427\|ref\|YP_002273798.1\| ornithine carbamoyltransferase [Escherichia coli O157:H7 str. EC411... gi\|217326119, gi... - gi\|217326119\|ref\|ZP_03442203.1\| ornithine carbamoyltransferase [Escherichia coli O157:H7 str. TW1458... gi\|189379487, gi... - gi\|189379487\|gb\|EDU97903.1\| ornithine carbamoyltransferase [Escherichia coli O157:H7 str. EC508], gi... gi\|195937279 - gi\|195937279\|ref\|ZP_03082661.1\| ornithine carbamoyltransferase subunit I [Escherichia coli O157:H7 s... gi\|208725707, gi... - gi\|208805906\|ref\|ZP_03248243.1\| ornithine carbamoyltransferase [Escherichia coli O157:H7 str. EC4206... gi\|208733293, gi... - gi\|208812016\|ref\|ZP_03253345.1\| ornithine carbamoyltransferase [Escherichia coli O157:H7 str. EC4045... gi\|189363939, gi... - gi\|189363939\|gb\|EDU82358.1\| ornithine carbamoyltransferase [Escherichia coli O157:H7 str. EC4486], g... gi\|168774026, gi... - gi\|187770253\|gb\|EDU34097.1\| ornithine carbamoyltransferase [Escherichia coli O157:H7 str. EC4196], g... gi\|168782779, gi... - gi\|188999816\|gb\|EDU68802.1\| ornithine carbamoyltransferase [Escherichia coli O157:H7 str. EC4076], g... gi\|189375038, gi... - gi\|189375038\|gb\|EDU93454.1\| ornithine carbamoyltransferase [Escherichia coli O157:H7 str. EC869], gi... gi\|188014845, gi... - gi\|188014845\|gb\|EDU52967.1\| ornithine carbamoyltransferase [Escherichia coli O157:H7 str. EC4113], g... gi\|168754834, gi... - gi\|189357876\|gb\|EDU76295.1\| ornithine carbamoyltransferase [Escherichia coli O157:H7 str. EC4401], g... gi\|13364709, gi\|... - gi\|15834485\|ref\|NP_313258.1\| ornithine carbamoyltransferase subunit I [Escherichia coli O157:H7 str.... gi\|168760507, gi... - gi\|189368978\|gb\|EDU87394.1\| ornithine carbamoyltransferase [Escherichia coli O157:H7 str. EC4501], g... gi\|254796274, gi... - gi\|254796274\|ref\|YP_003081111.1\| ornithine carbamoyltransferase 1 [Escherichia coli O157:H7 str. TW1...	451.0	[0..1]	[334..1]

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Predicted Domain #1

Region A:
Residues: [1-334]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDLYKKHFL KLLDFTPAQF TSLLTLAAQL KADKKNGKEV QKLTGKNIAL IFEKDSTRTR  60
   61 CSFEVAAFDQ GARVTYLGPS GSQIGHKESI KDTARVLGRM YDGIQYRGHG QEVVETLAQY 120
  121 AGVPVWNGLT NEFHPTQLLA DLMTMQEHLP GKAFNEMTLV YAGDARNNMG NSMLEAAALT 180
  181 GLDLRLLAPK ACWPEESLVA ECSALAEKHG GKITLTEDVA AGVKGADFIY TDVWVSMGEA 240
  241 KEKWAERIAL LRGYQVNAQM MALTDNPNVK FLHCLPAFHD DQTTLGKQMA KEFDLHGGME 300
  301 VTDEVFESAA SIVFDQAENR MHTIKAVMMA TLGE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	126.0
Match:	1akmA
Description:	Ornithine transcarbamoylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ornithine carbamoyltransferase activity	6.08861672645671	bayes_pls_golite062009
carboxyl- or carbamoyltransferase activity	5.32518877756022	bayes_pls_golite062009
aspartate carbamoyltransferase activity	3.84118892938517	bayes_pls_golite062009
transferase activity	2.2887439598954	bayes_pls_golite062009
carbamoyl-phosphate synthase activity	2.21516900257798	bayes_pls_golite062009
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	2.19154218663721	bayes_pls_golite062009
catalytic activity	2.06069688716378	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	1.54712264845123	bayes_pls_golite062009
binding	1.00470116390248	bayes_pls_golite062009
dihydroorotase activity	0.585784960037124	bayes_pls_golite062009
protein binding	0.171217252293449	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: