YRC Public Data Repository - Protein Structure Prediction

Protein:	LEU1_ECOLI
Organism:	Escherichia coli
Length:	523 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LEU1_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|89104762, gi\|... - gi\|89104762\|ref\|ZP_01177296.1\| COG0119: Isopropylmalate/homocitrate/citramalate synthases [Yersinia ... LEU1_YERPA - 2-isopropylmalate synthase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=leuA PE=3 SV=1 gi\|165992051, gi... - gi\|166008712\|ref\|ZP_02229610.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Antiqua str. E197... LEU1_YERPS - 2-isopropylmalate synthase OS=Yersinia pseudotuberculosis GN=leuA PE=3 SV=1 gi\|165919820, gi... - gi\|165928209\|ref\|ZP_02224041.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Orientalis str. F... gi\|167049327, gi... - gi\|167401302\|ref\|ZP_02306802.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Antiqua str. UG05... gi\|166206878, gi... - gi\|166212132\|ref\|ZP_02238167.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Antiqua str. B420... gi\|45443381, gi\|... - gi\|45443381\|ref\|NP_994920.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Microtus str. 91001]... gi\|16120862, gi\|... - gi\|218927730\|ref\|YP_002345605.1\| 2-isopropylmalate synthase [Yersinia pestis CO92], gi\|16120862\|ref\|... LEU1_YERPS - 2-isopropylmalate synthase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=leuA PE=3 S... LEU1_YERPG - 2-isopropylmalate synthase OS=Yersinia pestis bv. Antiqua (strain Angola) GN=leuA PE=3 SV=1 LEU1_YERP3 - 2-isopropylmalate synthase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=leuA PE... LEU1_YERPN - 2-isopropylmalate synthase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=leuA PE=3 SV=1 LEU1_YERPE - 2-isopropylmalate synthase OS=Yersinia pestis GN=leuA PE=3 SV=1 gi\|167469504 - gi\|167469504\|ref\|ZP_02334208.1\| 2-isopropylmalate synthase [Yersinia pestis FV-1] gi\|166960132, gi... - gi\|167421995\|ref\|ZP_02313748.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Orientalis str. M... LEU1_YERPB - 2-isopropylmalate synthase OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=leuA PE=3 SV... gi\|149289839, gi... - gi\|150260431\|ref\|ZP_01917159.1\| 2-isopropylmalate synthase [Yersinia pestis CA88-4125], gi\|149289839... LEU1_YERPY - 2-isopropylmalate synthase OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) GN=leuA PE=3 S... gi\|229836878, gi... - gi\|229836878\|ref\|ZP_04457043.1\| 2-isopropylmalate synthase [Yersinia pestis Pestoides A], gi\|2297058... LEU1_YERPP - 2-isopropylmalate synthase OS=Yersinia pestis (strain Pestoides F) GN=leuA PE=3 SV=1 gi\|229840424, gi... - gi\|229840424\|ref\|ZP_04460583.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Orientalis str. P... gi\|229843035, gi... - gi\|229843035\|ref\|ZP_04463185.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Orientalis str. I...	613.0	[0..1]	[523..1]
gi\|238718475, gi... - gi\|77962082\|ref\|ZP_00825907.1\| COG0119: Isopropylmalate/homocitrate/citramalate synthases [Yersinia ...	611.0	[0..1]	[523..1]
gi\|238714551, gi... - gi\|77958251\|ref\|ZP_00822288.1\| COG0119: Isopropylmalate/homocitrate/citramalate synthases [Yersinia ...	611.0	[0..1]	[523..1]
gi\|22127519, gi\|... - gi\|22127519\|ref\|NP_670942.1\| 2-isopropylmalate synthase [Yersinia pestis KIM], gi\|21960619\|gb\|AAM871... gi\|167054582, gi... - gi\|167426484\|ref\|ZP_02318237.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Mediaevalis str. ...	611.0	[0..1]	[523..1]
gi\|238725074, gi... - gi\|77976116\|ref\|ZP_00831649.1\| COG0119: Isopropylmalate/homocitrate/citramalate synthases [Yersinia ...	610.0	[0..1]	[523..1]
gi\|238729289, gi... - gi\|77977568\|ref\|ZP_00833013.1\| COG0119: Isopropylmalate/homocitrate/citramalate synthases [Yersinia ...	609.0	[0..1]	[523..1]
gi\|194456533, gi... - gi\|194470169\|ref\|ZP_03076153.1\| 2-isopropylmalate synthase [Salmonella enterica subsp. enterica sero... LEU1_SALSV - 2-isopropylmalate synthase OS=Salmonella schwarzengrund (strain CVM19633) GN=leuA PE=3 SV=1 gi\|197243351, gi... - gi\|197265096\|ref\|ZP_03165170.1\| 2-isopropylmalate synthase [Salmonella enterica subsp. enterica sero... LEU1_SALDC - 2-isopropylmalate synthase OS=Salmonella dublin (strain CT_02021853) GN=leuA PE=3 SV=1 lcl\|NC_016856.1_... - [gene=leuA] [protein=2-isopropylmalate synthase] [protein_id=YP_005235767.1] [location=complement(13... gi\|168262205, gi... - gi\|205348821\|gb\|EDZ35452.1\| 2-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar ... gi\|168464339, gi... - gi\|195632830\|gb\|EDX51284.1\| 2-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar ... gi\|205342405, gi... - gi\|205342405\|gb\|EDZ29169.1\| 2-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar ... LEU1_SALHS - 2-isopropylmalate synthase OS=Salmonella heidelberg (strain SL476) GN=leuA PE=3 SV=1 gi\|205331293, gi... - gi\|205331293\|gb\|EDZ18057.1\| 2-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar ... gi\|205335105, gi... - gi\|205335105\|gb\|EDZ21869.1\| 2-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar ... gi\|168234874, gi... - gi\|197291975\|gb\|EDY31325.1\| 2-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar ... gi\|205337488, gi... - gi\|205337488\|gb\|EDZ24252.1\| 2-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar ... LEU1_SALPB - 2-isopropylmalate synthase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=leuA PE=3 SV=1 LEU1_SALPB - 2-isopropylmalate synthase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=leuA PE=3 SV=1 gi\|238911171 - gi\|238911171\|ref\|ZP_04655008.1\| 2-isopropylmalate synthase [Salmonella enterica subsp. enterica sero... LEU1_SALTY - 2-isopropylmalate synthase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=leuA P... LEU1_SALTY - 2-isopropylmalate synthase OS=Salmonella typhimurium GN=leuA PE=3 SV=4 gi\|204927123, gi... - gi\|204927123\|ref\|ZP_03218325.1\| 2-isopropylmalate synthase [Salmonella enterica subsp. enterica sero... LEU1_SALG2 - 2-isopropylmalate synthase OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=leuA PE=3 SV=1 LEU1_SALEP - 2-isopropylmalate synthase OS=Salmonella enteritidis PT4 (strain P125109) GN=leuA PE=3 SV=1 LEU1_SALTY - 2-isopropylmalate synthase OS=Salmonella typhimurium GN=leuA PE=3 SV=4	603.0	[0..1]	[523..1]
LEU1_SALCH - 2-isopropylmalate synthase OS=Salmonella choleraesuis GN=leuA PE=3 SV=1 LEU1_SALPC - 2-isopropylmalate synthase OS=Salmonella paratyphi C (strain RKS4594) GN=leuA PE=3 SV=1 LEU1_SALCH - 2-isopropylmalate synthase OS=Salmonella choleraesuis (strain SC-B67) GN=leuA PE=3 SV=1	603.0	[0..1]	[523..1]
LEU1_SALPK - 2-isopropylmalate synthase OS=Salmonella paratyphi A (strain AKU_12601) GN=leuA PE=3 SV=1 LEU1_SALPA - 2-isopropylmalate synthase OS=Salmonella paratyphi A GN=leuA PE=3 SV=1 LEU1_SALPA - 2-isopropylmalate synthase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=leuA PE=3 SV=1	603.0	[0..1]	[523..1]
LEU1_SHISS - 2-isopropylmalate synthase OS=Shigella sonnei (strain Ss046) GN=leuA PE=3 SV=1	602.0	[0..1]	[523..1]

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Predicted Domain #1

Region A:
Residues: [1-523]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQQVIIFDT TLRDGEQALQ ASLSVKEKLQ IALALERMGV DVMEVGFPVS SPGDFESVQT  60
   61 IARQVKNSRV CALARCVEKD IDVAAESLKV AEAFRIHTFI ATSPMHIATK LRSTLDEVIE 120
  121 RAIYMVKRAR NYTDDVEFSC EDAGRTPIAD LARVVEAAIN AGATTINIPD TVGYTMPFEF 180
  181 AGIISGLYER VPNIDKAIIS VHTHDDLGLA VGNSLAAVHA GARQVEGAMN GIGERAGNCS 240
  241 LEEVIMAIKV RKDILNVHTA INHQEIWRTS QLVSQICNMP IPANKAIVGS GAFAHSSGIH 300
  301 QDGVLKNREN YEIMTPESIG LNQIQLNLTS RSGRAAVKHR MDEMGYKESE YNLDNLYDAF 360
  361 LKLADKKGQV FDYDLEALAF IGKQQEEPEH FRLDYFSVQS GSNDIATAAV KLACGEEVKA 420
  421 EAANGNGPVD AVYQAINRIT EYNVELVKYS LTAKGHGKDA LGQVDIVANY NGRRFHGVGL 480
  481 ATDIVESSAK AMVHVLNNIW RAAEVEKELQ RKAQHNENNK ETV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	116.0
Match:	1sr9A
Description:	Crystal Structure of LeuA from Mycobacterium tuberculosis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
2-isopropylmalate synthase activity	3.07962096729216	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	2.96685031644778	bayes_pls_golite062009
catalytic activity	2.67031204377352	bayes_pls_golite062009
porphobilinogen synthase activity	1.24455949903754	bayes_pls_golite062009
lyase activity	0.740424046054758	bayes_pls_golite062009
binding	0.584966797881465	bayes_pls_golite062009
transferase activity	0.464721888799972	bayes_pls_golite062009
dihydrodipicolinate synthase activity	0.40053008506995	bayes_pls_golite062009
transaldolase activity	0.184100272651834	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: