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Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. Catalysis of the reaction: acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: 2-isopropylmalate synthase activity
Acc: GO:0003852
Aspect: Molecular Function
Desc: Catalysis of the reaction: acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA.
Synonyms:
  • alpha-IPM synthetase activity
  • isopropylmalate synthase activity
  • isopropylmalate synthetase activity
  • alpha-isopropylmalate synthetase activity
  • alpha-isopropylmalic synthetase activity
  • 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity
  • alpha-isopropylmalate synthase activity
  • acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Proteins in PDR annotated with:
   This term: 17 [Search]
   Term or descendants: 17 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0003852 - 2-isopropylmalate synthase activity (interactive image map)
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