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View Structure Prediction Details

Protein: SENP2
Organism: Homo sapiens
Length: 589 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SENP2.

Description E-value Query
Range
Subject
Range
gi|14042385 - gi|14042385|dbj|BAB55222.1| unnamed protein product [Homo sapiens]
0.0 [1..589] [1..589]
SENP2_PONAB - Sentrin-specific protease 2 OS=Pongo abelii GN=SENP2 PE=2 SV=1
SENP2_PONPY - Sentrin-specific protease 2 - Pongo pygmaeus (Orangutan)
0.0 [1..589] [1..589]
gi|109042343 - gi|109042343|ref|XP_001095662.1| PREDICTED: SUMO1/sentrin/SMT3 specific protease 2 isoform 2 [Macaca...
0.0 [1..589] [1..588]
gi|74003536 - gi|74003536|ref|XP_535831.2| PREDICTED: similar to Sentrin-specific protease 2 (Sentrin/SUMO-specifi...
0.0 [1..589] [1..590]
gi|114590909 - gi|114590909|ref|XP_516925.2| PREDICTED: similar to KIAA1331 protein [Pan troglodytes]
0.0 [1..589] [249..821]
SENP2_MOUSE - Sentrin-specific protease 2 OS=Mus musculus GN=Senp2 PE=1 SV=2
0.0 [1..589] [1..588]
SENP2_RAT - Sentrin-specific protease 2 OS=Rattus norvegicus GN=Senp2 PE=1 SV=1
0.0 [1..589] [1..588]

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Predicted Domain #1
Region A:
Residues: [1-71]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYRWLVRILG TIFRFCDRSV PPARALLKRR RSDSTLFSTV DTDEIPAKRP RLDCFIHQVK  60
   61 NSLYNAASLF G

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [72-263]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FPFQLTTKPM VTSACNGTRN VAPSGEVFSN SSSCELTGSG SWNNMLKLGN KSPNGISDYP  60
   61 KIRVTVTRDQ PRRVLPSFGF TLNSEGCNRR PGGRRHSKGN PESSLMWKPQ EQAVTEMISE 120
  121 ESGKGLRRPH CTVEEGVQKE EREKYRKLLE RLKESGHGNS VCPVTSNYHS SQRSQMDTLK 180
  181 TKGWGEEQNH GV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [264-365]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTTQFVPKQY RLVETRGPLC SLRSEKRCSK GKITDTETMV GIRFENESRR GYQLEPDLSE  60
   61 EVSARLRLGS GSNGLLRRKV SIIETKEKNC SGKERDRRTD DL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [366-589]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LELTEDMEKE ISNALGHGPQ DEILSSAFKL RITRGDIQTL KNYHWLNDEV INFYMNLLVE  60
   61 RNKKQGYPAL HVFSTFFYPK LKSGGYQAVK RWTKGVNLFE QEIILVPIHR KVHWSLVVID 120
  121 LRKKCLKYLD SMGQKGHRIC EILLQYLQDE SKTKRNSDLN LLEWTHHSMK PHEIPQQLNG 180
  181 SDCGMFTCKY ADYISRDKPI TFTQHQMPLF RKKMVWEILH QQLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 65.69897
Match: 1tgzA
Description: Structure of human Senp2 in complex with SUMO-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
SUMO-specific protease activity 7.14791995103471 bayes_pls_golite062009
cysteine-type peptidase activity 6.54685807643041 bayes_pls_golite062009
small conjugating protein-specific protease activity 6.39247995905454 bayes_pls_golite062009
ubiquitin-specific protease activity 5.52987342617304 bayes_pls_golite062009
ubiquitin thiolesterase activity 3.91170685383331 bayes_pls_golite062009
peptidase activity 2.99092799770282 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.70509346529146 bayes_pls_golite062009
hydrolase activity 2.66167923792227 bayes_pls_golite062009
endopeptidase activity 2.56654871607946 bayes_pls_golite062009
thiolester hydrolase activity 2.1617608442198 bayes_pls_golite062009
binding 1.92046698500094 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.79166977301695 bayes_pls_golite062009
signal transducer activity 1.5684982941305 bayes_pls_golite062009
molecular transducer activity 1.5684982941305 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 0.874003454509364 bayes_pls_golite062009
NEDD8-specific protease activity 0.687958315289315 bayes_pls_golite062009
nucleic acid binding 0.439226369799415 bayes_pls_golite062009
transcription regulator activity 0.354062437867002 bayes_pls_golite062009
DNA binding 0.306964954191276 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.144331158319621 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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