YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30255354, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	506 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30255354, gi|....

Description	E-value	Query Range	Subject Range
LEU1_BUCAP - 2-isopropylmalate synthase OS=Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) GN=leuA PE=... gi\|219730356\|emb... - unnamed protein product [Buchnera aphidicola], unnamed protein product [Buchnera aphidicola], unname... LEU1_BUCAP - 2-isopropylmalate synthase OS=Buchnera aphidicola subsp. Schizaphis graminum GN=leuA PE=3 SV=1	0.0	[3..505]	[4..507]
gi\|89104762, gi\|... - gi\|89104762\|ref\|ZP_01177296.1\| COG0119: Isopropylmalate/homocitrate/citramalate synthases [Yersinia ... LEU1_YERPA - 2-isopropylmalate synthase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=leuA PE=3 SV=1 gi\|165992051, gi... - gi\|166008712\|ref\|ZP_02229610.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Antiqua str. E197... LEU1_YERPS - 2-isopropylmalate synthase OS=Yersinia pseudotuberculosis GN=leuA PE=3 SV=1 gi\|165919820, gi... - gi\|165928209\|ref\|ZP_02224041.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Orientalis str. F... gi\|167049327, gi... - gi\|167401302\|ref\|ZP_02306802.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Antiqua str. UG05... gi\|166206878, gi... - gi\|166212132\|ref\|ZP_02238167.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Antiqua str. B420... gi\|45443381, gi\|... - gi\|45443381\|ref\|NP_994920.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Microtus str. 91001]... gi\|16120862, gi\|... - gi\|218927730\|ref\|YP_002345605.1\| 2-isopropylmalate synthase [Yersinia pestis CO92], gi\|16120862\|ref\|... LEU1_YERPS - 2-isopropylmalate synthase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=leuA PE=3 S... LEU1_YERPG - 2-isopropylmalate synthase OS=Yersinia pestis bv. Antiqua (strain Angola) GN=leuA PE=3 SV=1 LEU1_YERP3 - 2-isopropylmalate synthase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=leuA PE... LEU1_YERPN - 2-isopropylmalate synthase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=leuA PE=3 SV=1 LEU1_YERPE - 2-isopropylmalate synthase OS=Yersinia pestis GN=leuA PE=3 SV=1 gi\|167469504 - gi\|167469504\|ref\|ZP_02334208.1\| 2-isopropylmalate synthase [Yersinia pestis FV-1] gi\|166960132, gi... - gi\|167421995\|ref\|ZP_02313748.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Orientalis str. M... LEU1_YERPB - 2-isopropylmalate synthase OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=leuA PE=3 SV... gi\|149289839, gi... - gi\|150260431\|ref\|ZP_01917159.1\| 2-isopropylmalate synthase [Yersinia pestis CA88-4125], gi\|149289839... LEU1_YERPY - 2-isopropylmalate synthase OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) GN=leuA PE=3 S... gi\|229836878, gi... - gi\|229836878\|ref\|ZP_04457043.1\| 2-isopropylmalate synthase [Yersinia pestis Pestoides A], gi\|2297058... LEU1_YERPP - 2-isopropylmalate synthase OS=Yersinia pestis (strain Pestoides F) GN=leuA PE=3 SV=1 gi\|229840424, gi... - gi\|229840424\|ref\|ZP_04460583.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Orientalis str. P... gi\|229843035, gi... - gi\|229843035\|ref\|ZP_04463185.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Orientalis str. I...	0.0	[2..506]	[3..507]
LEU1_BUCAI - 2-isopropylmalate synthase OS=Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) GN=leuA PE... LEU1_BUCAI - 2-isopropylmalate synthase OS=Buchnera aphidicola subsp. Acyrthosiphon pisum GN=leuA PE=3 SV=3 gi\|219783132\|emb... - unnamed protein product [Buchnera aphidicola], unnamed protein product [Buchnera aphidicola], unname...	0.0	[1..506]	[1..508]
gi\|22127519, gi\|... - gi\|22127519\|ref\|NP_670942.1\| 2-isopropylmalate synthase [Yersinia pestis KIM], gi\|21960619\|gb\|AAM871... gi\|167054582, gi... - gi\|167426484\|ref\|ZP_02318237.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Mediaevalis str. ...	0.0	[2..506]	[3..507]
gi\|238718475, gi... - gi\|77962082\|ref\|ZP_00825907.1\| COG0119: Isopropylmalate/homocitrate/citramalate synthases [Yersinia ...	0.0	[2..505]	[3..506]
gi\|5912536 - gi\|5912536\|emb\|CAA07305.2\| 2-isoproylmalate synthase [Buchnera aphidicola]	0.0	[1..506]	[1..508]
gi\|238714551, gi... - gi\|77958251\|ref\|ZP_00822288.1\| COG0119: Isopropylmalate/homocitrate/citramalate synthases [Yersinia ...	0.0	[2..505]	[3..506]
gi\|238725074, gi... - gi\|77976116\|ref\|ZP_00831649.1\| COG0119: Isopropylmalate/homocitrate/citramalate synthases [Yersinia ...	0.0	[2..505]	[3..506]
gi\|238729289, gi... - gi\|77977568\|ref\|ZP_00833013.1\| COG0119: Isopropylmalate/homocitrate/citramalate synthases [Yersinia ...	0.0	[2..505]	[3..506]
LEU1_PHOLL - 2-isopropylmalate synthase OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 1055... LEU1_PHOLL - 2-isopropylmalate synthase OS=Photorhabdus luminescens subsp. laumondii GN=leuA PE=3 SV=1	0.0	[2..506]	[3..507]

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Predicted Domain #1

Region A:
Residues: [1-506]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQILFMDTT LRDGEQSPGV NLNEQEKLQI ARQLERLGIH VMEAGFAAAS EGDFQSVKRI  60
   61 ANTIQNATVM SLARAKESDI RRAYEAVKGA VSPRLHVFLA TSDIHMKYKL CMSKEDVLDS 120
  121 IYRSVTLGKS LFPTVQFSAE DATRTARDFL AEAVEVAIRA GANVINIPDT VGYTNPEEYY 180
  181 ALFKYLQESV PSYEKAIFSC HCHDDLGMAV ANSLAAVEGG ALQVEGTING IGERAGNAAL 240
  241 EEVAVALHIR KDFYKAEPSM TLKEIKATST LVSRLTGMVV SKNKAIVGAN AFAHESGIHQ 300
  301 DGVLKEVTTY EIIEPALVGE SQNLFVLGKH SGRHAFTEKM KELGYEFTND ERDAVFEAFK 360
  361 KLADRKKEIT EEDLRALMLG EAAFAAQQYN ITQLQVHFVS NSTQCATVVL KDEEGNVFED 420
  421 AATGSGSIEA IYNAIQRILG LECELADYRI QSITQGQDAL AHVHVELKEG AHQVSGFGVA 480
  481 QDVLEASARA YVHAAGKLKS FIQLVK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	110.0
Match:	1sr9A
Description:	Crystal Structure of LeuA from Mycobacterium tuberculosis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
2-isopropylmalate synthase activity	3.07962096729216	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	2.96685031644778	bayes_pls_golite062009
catalytic activity	2.67031204377352	bayes_pls_golite062009
porphobilinogen synthase activity	1.24455949903754	bayes_pls_golite062009
lyase activity	0.740424046054758	bayes_pls_golite062009
binding	0.584966797881465	bayes_pls_golite062009
transferase activity	0.464721888799972	bayes_pls_golite062009
transaldolase activity	0.184100272651834	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: