YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30253839, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	511 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30253839, gi|....

Description	E-value	Query Range	Subject Range
PUR9_BACWK - Bifunctional purine biosynthesis protein PurH OS=Bacillus weihenstephanensis (strain KBAB4) GN=purH ...	0.0	[1..511]	[1..511]
PUR9_BACC1 - Bifunctional purine biosynthesis protein PurH OS=Bacillus cereus (strain ATCC 10987 / NRS 248) GN=pu...	0.0	[1..511]	[1..511]
PUR9_SALTY - Bifunctional purine biosynthesis protein PurH OS=Salmonella typhimurium GN=purH PE=3 SV=2 lcl\|NC_016856.1_... - [gene=purH] [protein=bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cycl... PUR9_SALTY - Bifunctional purine biosynthesis protein purH OS=Salmonella typhimurium GN=purH PE=3 SV=2 PUR9_SALTY - Bifunctional purine biosynthesis protein PurH OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATC...	0.0	[3..511]	[8..529]
PUR9_SALPA - Bifunctional purine biosynthesis protein PurH OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) ... PUR9_SALPA - Bifunctional purine biosynthesis protein PurH OS=Salmonella paratyphi A GN=purH PE=3 SV=1 PUR9_SALPK - Bifunctional purine biosynthesis protein PurH OS=Salmonella paratyphi A (strain AKU_12601) GN=purH P...	0.0	[3..511]	[8..529]
gi\|68249474, gi\|... - gi\|68249474\|ref\|YP_248586.1\| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/...	0.0	[2..511]	[6..532]
PUR9_BACCR - Bifunctional purine biosynthesis protein PurH OS=Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2... gi\|228956720, gi... - gi\|228956720\|ref\|ZP_04118506.1\| IMP cyclohydrolase [Bacillus thuringiensis serovar pakistani str. T1... gi\|228634695, gi... - gi\|229148687\|ref\|ZP_04276937.1\| IMP cyclohydrolase [Bacillus cereus m1550], gi\|228634695\|gb\|EEK91274... gi\|228640356, gi... - gi\|229143083\|ref\|ZP_04271516.1\| IMP cyclohydrolase [Bacillus cereus BDRD-ST24], gi\|228640356\|gb\|EEK9... gi\|229125785, gi... - gi\|229125785\|ref\|ZP_04254811.1\| IMP cyclohydrolase [Bacillus cereus BDRD-Cer4], gi\|228657642\|gb\|EEL1... gi\|229107960, gi... - gi\|229107960\|ref\|ZP_04237587.1\| IMP cyclohydrolase [Bacillus cereus Rock1-15], gi\|228675463\|gb\|EEL30...	0.0	[1..511]	[1..511]
PUR9_YERPB - Bifunctional purine biosynthesis protein PurH OS=Yersinia pseudotuberculosis serotype IB (strain PB1... PUR9_YERPS - Bifunctional purine biosynthesis protein PurH OS=Yersinia pseudotuberculosis GN=purH PE=3 SV=1 PUR9_YERPY - Bifunctional purine biosynthesis protein PurH OS=Yersinia pseudotuberculosis serotype O:3 (strain YP... PUR9_YERPS - Bifunctional purine biosynthesis protein PurH OS=Yersinia pseudotuberculosis serotype I (strain IP32...	0.0	[2..511]	[7..529]
gi\|148826468, gi... - gi\|148826468\|ref\|YP_001291221.1\| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransfer... gi\|46129145 - gi\|46129145\|ref\|ZP_00155824.2\| COG0138: AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclo...	0.0	[2..511]	[6..532]
PUR9_VIBF1 - Bifunctional purine biosynthesis protein PurH OS=Vibrio fischeri (strain ATCC 700601 / ES114) GN=pur...	0.0	[2..511]	[7..530]
PUR9_ECOUT - Bifunctional purine biosynthesis protein PurH OS=Escherichia coli (strain UTI89 / UPEC) GN=purH PE=3... PUR9_ECOK1 - Bifunctional purine biosynthesis protein PurH OS=Escherichia coli O1:K1 / APEC GN=purH PE=3 SV=1 PUR9_ECO45 - Bifunctional purine biosynthesis protein PurH OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=pur... gi\|237702773, gi... - gi\|237702773\|ref\|ZP_04533254.1\| bifunctional purine biosynthesis protein purH [Escherichia sp. 3_2_5...	0.0	[3..511]	[8..529]

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Predicted Domain #1

Region A:
Residues: [1-511]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKRALVSVS DKTGVVEFVK GLLEQGIEVI STGGTKKLLE ENGLQVIGIS EVTGFPEIMD  60
   61 GRVKTLHPNI HGGLLAVRDN ETHVAQMNEL GMEPIDFVVV NLYPFKETIA KPDVTFADAI 120
  121 ENIDIGGPTM IRSAAKNHKF VSVIVDPVDY DVVLAELKEN GEVAEETKRK LAAKVFRHTA 180
  181 AYDALISNYL TEQMGEESPE TLTVTFEKKQ DLRYGENPHQ KATFYKAPFA ATSSVAYAEQ 240
  241 LHGKELSYNN INDADAALSI VKEFTEPAVV AVKHMNPCGV GVGTDIHEAY TRAYEADPVS 300
  301 IFGGIIAANR EIDKATAEKL HEIFLEIIIA PSFSKEALEV LQSKKNLRLL TVNIEKATSA 360
  361 SKKLTSVQGG LLVQEEDTLS LDESTISIPT KREPSEQEWK DLKLAWKVVK HVKSNAIVLA 420
  421 KDDMTIGVGA GQMNRVGSAK IAITQAGEKA QGSALASDAF FPMPDTVEEA AKAGITAIIQ 480
  481 PGGSIRDEDS IKVADTYGIA MVFTGVRHFK H

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1p4rA
Description:	Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
IMP cyclohydrolase activity	2.44338227123463	bayes_pls_golite062009
phosphoribosylaminoimidazolecarboxamide formyltransferase activity	2.17104645465987	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1.79965948308471	bayes_pls_golite062009
catalytic activity	1.70756445127105	bayes_pls_golite062009
hydroxymethyl-, formyl- and related transferase activity	1.51378035087272	bayes_pls_golite062009
glycine hydroxymethyltransferase activity	1.19388272840449	bayes_pls_golite062009
deaminase activity	1.16510523659661	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1.03324558866637	bayes_pls_golite062009
cytidine deaminase activity	0.870445440530128	bayes_pls_golite062009
binding	0.46651845554048	bayes_pls_golite062009
hydrolase activity	0.339145951258927	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: