YRC Public Data Repository - Protein Structure Prediction

Protein:	UPP_GEOSL
Organism:	Geobacter sulfurreducens PCA
Length:	209 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UPP_GEOSL.

Description	E-value	Query Range	Subject Range
UPP_STRSL - Uracil phosphoribosyltransferase OS=Streptococcus salivarius GN=upp PE=3 SV=1 gi\|228476631, gi... - gi\|228476631\|ref\|ZP_04061313.1\| uracil phosphoribosyltransferase [Streptococcus salivarius SK126], g...	246.0	[0..2]	[209..3]
gi\|89210214, gi\|... - gi\|89210214\|ref\|ZP_01188606.1\| Uracil phosphoribosyl transferase [Halothermothrix orenii H 168], gi\|...	245.0	[0..2]	[209..3]
gi\|229331222, gi... - gi\|229497796\|ref\|ZP_04391495.1\| uracil phosphoribosyltransferase [Geobacillus sp. Y412MC52], gi\|2293... gi\|1765902, gi\|2... - gi\|21465611\|pdb\|1I5E\|B Chain B, Crystal Structure Of Bacillus Caldolyticus Uracil Phosphoribosyltran... UPP_GEOKA - Uracil phosphoribosyltransferase OS=Geobacillus kaustophilus GN=upp PE=3 SV=1 gi\|220709118, gi... - gi\|221087065\|ref\|ZP_03556605.1\| uracil phosphoribosyltransferase [Geobacillus sp. Y412MC61], gi\|2207... UPP_GEOKA - Uracil phosphoribosyltransferase OS=Geobacillus kaustophilus (strain HTA426) GN=upp PE=3 SV=1	245.0	[0..2]	[209..3]
gi\|55736433, gi\|... - gb\|AAV61958.1\| uracil phosphoribosyltransferase [Streptococcus thermophilus CNRZ1066], gb\|AAV60075.... UPP_STRT2 - Uracil phosphoribosyltransferase OS=Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) GN=... UPP_STRTD - Uracil phosphoribosyltransferase OS=Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9) GN=upp ... UPP_STRT1 - Uracil phosphoribosyltransferase OS=Streptococcus thermophilus (strain CNRZ 1066) GN=upp PE=3 SV=1	245.0	[0..2]	[209..3]
UPP_STRA3 - Uracil phosphoribosyltransferase OS=Streptococcus agalactiae serotype III (strain NEM316) GN=upp PE=... UPP_STRA5 - Uracil phosphoribosyltransferase OS=Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 ... UPP_STRA1 - Uracil phosphoribosyltransferase OS=Streptococcus agalactiae serotype Ia GN=upp PE=3 SV=1 UPP_STRA5 - Uracil phosphoribosyltransferase OS=Streptococcus agalactiae serotype V GN=upp PE=3 SV=1 UPP_STRA1 - Uracil phosphoribosyltransferase OS=Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 /... gi\|77414902, gi\|... - gi\|77414902\|ref\|ZP_00791007.1\| uracil phosphoribosyltransferase [Streptococcus agalactiae 515], gi\|7... gi\|77409460, gi\|... - gi\|77409460\|ref\|ZP_00786153.1\| uracil phosphoribosyltransferase [Streptococcus agalactiae COH1], gi\|... gi\|77174294, gi\|... - gi\|77407099\|ref\|ZP_00784099.1\| uracil phosphoribosyltransferase [Streptococcus agalactiae H36B], gi\|... UPP_STRA3 - Uracil phosphoribosyltransferase OS=Streptococcus agalactiae serotype III GN=upp PE=3 SV=1	244.0	[0..2]	[209..3]
UPP_EXIS2 - Uracil phosphoribosyltransferase OS=Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15...	244.0	[0..2]	[209..3]
gi\|89089364, gi\|... - gi\|89095618\|ref\|ZP_01168512.1\| uracil phosphoribosyltransferase [Bacillus sp. NRRL B-14911], gi\|8908...	243.0	[0..2]	[209..3]
UPP_PEDPA - Uracil phosphoribosyltransferase OS=Pediococcus pentosaceus (strain ATCC 25745 / 183-1w) GN=upp PE=3...	243.0	[0..2]	[209..3]
UPP_STRMU - Uracil phosphoribosyltransferase OS=Streptococcus mutans serotype c (strain ATCC 700610 / UA159) GN=... gi\|254996869 - gi\|254996869\|dbj\|BAH87470.1\| uracil phosphoribosyltransferase [Streptococcus mutans NN2025] UPP_STRMU - Uracil phosphoribosyltransferase OS=Streptococcus mutans GN=upp PE=3 SV=1	243.0	[0..2]	[209..3]
UPP_BACCL - Uracil phosphoribosyltransferase OS=Bacillus caldolyticus GN=upp PE=1 SV=2	242.0	[0..2]	[209..3]

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Predicted Domain #1

Region A:
Residues: [1-209]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVHELTHPL VRHKIGLMRE ADISTKKFRE LAAELARLLA YEACGDFPLE VRTITGWDGN  60
   61 PVEIEQIKGK KVTVVPILRA GIGMLDGVLD MIPNAKVSVV GLARNEETLE AHTYLEKFVD 120
  121 KLDERLAVIL DPMLATGGSM EATISMLKRN GCRQIRVLAL VAAPEGLARV TAAHPDVDIY 180
  181 VAAIDRCLNE HGYILPGLGD AGDKIFGTK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	65.30103
Match:	1i5eA
Description:	Uracil PRTase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uracil phosphoribosyltransferase activity	3.97944228585882	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	3.91023158228049	bayes_pls_golite062009
adenine phosphoribosyltransferase activity	3.07502596276449	bayes_pls_golite062009
transferase activity	2.73727660668741	bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity	2.67945744445872	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	2.53679639481311	bayes_pls_golite062009
catalytic activity	2.30431811394775	bayes_pls_golite062009
ribose phosphate diphosphokinase activity	0.947697983706416	bayes_pls_golite062009
diphosphotransferase activity	0.749909396904601	bayes_pls_golite062009
nucleic acid binding	0.552133387792911	bayes_pls_golite062009
binding	0.535390228935555	bayes_pls_golite062009
DNA binding	0.439741935655503	bayes_pls_golite062009
transcription regulator activity	0.396538943915776	bayes_pls_golite062009
amidophosphoribosyltransferase activity	0.360901350940423	bayes_pls_golite062009
purine binding	0.358545436706029	bayes_pls_golite062009
orotate phosphoribosyltransferase activity	0.148898393751978	bayes_pls_golite062009
nucleobase binding	0.0803493215714011	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: