YRC Public Data Repository - Protein Structure Prediction

Protein:	ADD_SHEON
Organism:	Shewanella oneidensis MR-1
Length:	331 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADD_SHEON.

Description	E-value	Query Range	Subject Range
gi\|24113013, gi\|... - gi\|24113013\|ref\|NP_707523.1\| adenosine deaminase [Shigella flexneri 2a str. 301], gi\|24051977\|gb\|AAN... gi\|30041387, gi\|... - gi\|30063138\|ref\|NP_837309.1\| adenosine deaminase [Shigella flexneri 2a str. 2457T], gi\|30041387\|gb\|A... ADD_SHIF8 - Adenosine deaminase OS=Shigella flexneri serotype 5b (strain 8401) GN=add PE=3 SV=1 ADD_SHIFL - Adenosine deaminase OS=Shigella flexneri GN=add PE=3 SV=1	268.0	[0..1]	[331..1]
ADE_ACIAD - Adenine deaminase OS=Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) GN=ACIAD1245 PE=3 SV=1	268.0	[0..2]	[329..6]
ADD_VIBPA - Adenosine deaminase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN=add PE=3 SV=1 ADD_VIBPA, ADD1_... - Adenosine deaminase OS=Vibrio parahaemolyticus GN=add PE=3 SV=1, Adenosine deaminase 1 OS=Vibrio par...	268.0	[0..1]	[329..1]
ADD_CLOAB - Adenosine deaminase OS=Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 /... ADD_CLOAB - Adenosine deaminase OS=Clostridium acetobutylicum GN=add PE=3 SV=1	267.0	[0..3]	[329..7]
ADD_ECOK1 - Adenosine deaminase OS=Escherichia coli O1:K1 / APEC GN=add PE=3 SV=1 ADD_ECOL6 - Adenosine deaminase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=add PE=3 SV=1 ADD_ECOL5 - Adenosine deaminase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=add PE=3 SV=1 gi\|75238816, gi\|... - gi\|75238816\|ref\|ZP_00722800.1\| COG1816: Adenosine deaminase [Escherichia coli F11], gi\|191173422\|ref... ADD_ECOUT - Adenosine deaminase OS=Escherichia coli (strain UTI89 / UPEC) GN=add PE=3 SV=1 ADD_ECO45 - Adenosine deaminase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=add PE=3 SV=1 gi\|227837054, gi... - gi\|227885962\|ref\|ZP_04003767.1\| adenosine deaminase [Escherichia coli 83972], gi\|227837054\|gb\|EEJ475... gi\|237705564, gi... - gi\|237705564\|ref\|ZP_04536045.1\| adenosine deaminase [Escherichia sp. 3_2_53FAA], gi\|226900321\|gb\|EEH... ADD_ECOL6 - Adenosine deaminase OS=Escherichia coli O6 GN=add PE=3 SV=1	266.0	[0..1]	[331..1]
ADD_SHEFN - Adenosine deaminase OS=Shewanella frigidimarina (strain NCIMB 400) GN=add PE=3 SV=1	266.0	[0..1]	[331..1]
ADD_SHISS - Adenosine deaminase OS=Shigella sonnei (strain Ss046) GN=add PE=3 SV=1	265.0	[0..1]	[331..1]
ADE_HAHCH - Adenine deaminase OS=Hahella chejuensis (strain KCTC 2396) GN=HCH_01503 PE=3 SV=1	265.0	[0..4]	[329..6]
ADD_SHIB3 - Adenosine deaminase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=add PE=3 SV=1 ADD_SHIBS - Adenosine deaminase OS=Shigella boydii serotype 4 (strain Sb227) GN=add PE=3 SV=1	265.0	[0..1]	[331..1]
ADD_SHESA - Adenosine deaminase OS=Shewanella sp. (strain ANA-3) GN=add PE=3 SV=1	264.0	[0..1]	[331..1]

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Predicted Domain #1

Region A:
Residues: [1-331]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MINTSIPLVD LHRHLDGNVR VNTIWELGHQ HGIALPADSL ETLAPFVQIQ GKETSLVAFL  60
   61 KKLDWMVAVL ADLDAVKRIA YENVADAALS GLDYAELRFS PYYMAMNHKL PIEGVVEAVI 120
  121 DGVKAGLKDY QVNINLIGIM SRSFGQPACT QELEGLLAHK QHLVAMDLAG DELGFPGELF 180
  181 NEHFKRVRDA GLAITAHAGE AAGSQSMWQA IQELGATRIG HGVNAIHDPK LMEYLAKHRI 240
  241 GIESCPTSNL HTSTVSSYAE HPFRTFMDAG VLIGLNTDDP GVSAIDIKHE YRIAKFELGL 300
  301 SDAELAQVQR NGVEMAFLSE SERKALYAAK A

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.69897
Match:	1ndvA
Description:	Crystal Structure of Adenosine Deaminase complexed with FR117016
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
purine nucleoside binding	5.77008212157543	bayes_pls_golite062009
adenosine deaminase activity	4.58148305437166	bayes_pls_golite062009
hydrolase activity	3.62199995345412	bayes_pls_golite062009
dihydropyrimidinase activity	2.71615654592807	bayes_pls_golite062009
deaminase activity	1.79186203771221	bayes_pls_golite062009
catalytic activity	1.70199291046899	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1.60895003474033	bayes_pls_golite062009
binding	1.20793368650496	bayes_pls_golite062009
protein binding	0.928500526896831	bayes_pls_golite062009
guanine deaminase activity	0.861706835095856	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	0.787370269329878	bayes_pls_golite062009
adenine deaminase activity	0.644540226937277	bayes_pls_golite062009
nucleic acid binding	0.629962267754185	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.573107361273483	bayes_pls_golite062009
transcription regulator activity	0.530552339840648	bayes_pls_golite062009
DNA binding	0.462348875991261	bayes_pls_golite062009
glycosaminoglycan binding	0.408989331337656	bayes_pls_golite062009
peptidase activity	0.356051335471361	bayes_pls_golite062009
dihydroorotase activity	0.203044795244555	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: