YRC Public Data Repository - Protein Structure Prediction

Protein:	PUR9_SHEON
Organism:	Shewanella oneidensis MR-1
Length:	543 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PUR9_SHEON.

Description	E-value	Query Range	Subject Range
gi\|54310485, gi\|... - gi\|54310485\|ref\|YP_131505.1\| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/...	835.0	[0..1]	[543..1]
gi\|68249474, gi\|... - gi\|68249474\|ref\|YP_248586.1\| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/...	835.0	[0..9]	[543..5]
gi\|148826468, gi... - gi\|148826468\|ref\|YP_001291221.1\| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransfer... gi\|46129145 - gi\|46129145\|ref\|ZP_00155824.2\| COG0138: AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclo...	834.0	[0..9]	[543..5]
PUR9_HAES1 - Bifunctional purine biosynthesis protein PurH OS=Haemophilus somnus (strain 129Pt) GN=purH PE=3 SV=1	832.0	[0..9]	[543..6]
PUR9_HISS2 - Bifunctional purine biosynthesis protein PurH OS=Histophilus somni (strain 2336) GN=purH PE=3 SV=1	831.0	[0..9]	[543..6]
PUR9_VIBF1 - Bifunctional purine biosynthesis protein PurH OS=Vibrio fischeri (strain ATCC 700601 / ES114) GN=pur...	830.0	[0..4]	[543..1]
PUR9_HAEIN - Bifunctional purine biosynthesis protein purH OS=Haemophilus influenzae GN=purH PE=3 SV=1 PUR9_HAEIN - Bifunctional purine biosynthesis protein PurH OS=Haemophilus influenzae (strain ATCC 51907 / DSM 111...	830.0	[0..9]	[543..5]
gi\|84393071, gi\|... - gi\|84393071\|ref\|ZP_00991837.1\| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferas...	830.0	[0..4]	[543..1]
gi\|85834309, gi\|... - gi\|86147882\|ref\|ZP_01066187.1\| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferas...	830.0	[0..4]	[543..1]
gi\|42631211 - gi\|42631211\|ref\|ZP_00156749.1\| COG0138: AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclo... gi\|145638293, gi... - gi\|145638293\|ref\|ZP_01793903.1\| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransfera...	829.0	[0..9]	[543..5]

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Predicted Domain #1

Region A:
Residues: [1-543]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVANHARPI RRALLSVSDK TGILEFAKAL HAQGVELLST GGTARLLADN GVPVIEVSDY  60
   61 TGHPEIMDGR VKTLHPKVHG GILARRGLDE NVMAANNINA IDLVAVNLYP FADTVAKAGC 120
  121 TLEDAIENID IGGPTMVRAA AKNHKDVTIV VNAADYNRVL AEMAVNNGST THATRFDLAI 180
  181 AAFEHTAGYD GMIANYFGTM VPMHRVPAHS TDECFQDSLS VEGSKFPRTF NTQLVKKQDL 240
  241 RYGENSHQAA AFYVDTKIDE ASVATAVQLQ GKALSYNNIA DTDAALECVK EFSEPACVIV 300
  301 KHANPCGVAL GKDLLDAYNR AYQTDPTSAF GGIIAFNGEL DAATASAIVE RQFVEVIIAP 360
  361 VVSQGARDVV AKKTNVRLLE CGQWNTKTQT LDYKRVNGGL LVQDRDQGMV GLDDIKVVTK 420
  421 RQPTESELKD LMFCWKVAKF VKSNAIVYAK DGMTIGVGAG QMSRVYSAKI AGIKAADEGL 480
  481 EVVNSVMASD AFFPFRDGID AAAAAGISCI IQPGGSMRDA EIIAAADEHG MAMVMTGMRH 540
  541 FRH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	165.0
Match:	1p4rA
Description:	Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
IMP cyclohydrolase activity	2.44338227123463	bayes_pls_golite062009
phosphoribosylaminoimidazolecarboxamide formyltransferase activity	2.17104645465987	bayes_pls_golite062009
formate dehydrogenase activity	2.1190774640451	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1.79965948308471	bayes_pls_golite062009
catalytic activity	1.70756445127105	bayes_pls_golite062009
hydroxymethyl-, formyl- and related transferase activity	1.51378035087272	bayes_pls_golite062009
glycine hydroxymethyltransferase activity	1.19388272840449	bayes_pls_golite062009
deaminase activity	1.16510523659661	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1.03324558866637	bayes_pls_golite062009
cytidine deaminase activity	0.870445440530128	bayes_pls_golite062009
binding	0.778641298104072	bayes_pls_golite062009
oxidoreductase activity	0.738911503392967	bayes_pls_golite062009
hydrolase activity	0.339145951258927	bayes_pls_golite062009
protein binding	0.095488575269861	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: