YRC Public Data Repository - Protein Structure Prediction

Protein:	THDH_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	576 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THDH_YEAST.

Description	E-value	Query Range	Subject Range
ILV1 - Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under genera... THDH_YEAST - Threonine dehydratase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ILV... gi\|151944802 - gi\|151944802\|gb\|EDN63061.1\| threonine deaminase [Saccharomyces cerevisiae YJM789]	0.0	[1..576]	[1..576]
gi\|218889072, gi... - gi\|218889072\|ref\|YP_002437936.1\| threonine dehydratase [Pseudomonas aeruginosa LESB58], gi\|218769295... gi\|11352637 - pir\|\|F83603 threonine dehydratase, biosynthetic PA0331 [imported] - Pseudomonas aeruginosa (strain P... gi\|254237434, gi... - gi\|84318487\|ref\|ZP_00966910.1\| COG1171: Threonine dehydratase [Pseudomonas aeruginosa C3719], gi\|254... gi\|254243429, gi... - gi\|84324414\|ref\|ZP_00972472.1\| COG1171: Threonine dehydratase [Pseudomonas aeruginosa 2192], gi\|2542... gi\|15595528, gi\|... - gi\|9946179\|gb\|AAG03720.1\|AE004471_3 threonine dehydratase, biosynthetic [Pseudomonas aeruginosa PAO1... gi\|107099314 - gi\|107099314\|ref\|ZP_01363232.1\| hypothetical protein PaerPA_01000326 [Pseudomonas aeruginosa PACS2]	0.0	[62..574]	[4..503]
gi\|7436913 - pir\|\|S77559 threonine ammonia-lyase (EC 4.3.1.19) - Synechocystis sp. (strain PCC 6803) gi\|16329998, gi\|... - gi\|1652484\|dbj\|BAA17406.1\| L-threonine deaminase [Synechocystis sp. PCC 6803], gi\|16329998\|ref\|NP_44...	0.0	[60..575]	[2..508]
gi\|229369241, gi... - gi\|229606586\|ref\|YP_002877234.1\| threonine dehydratase biosynthetic [Vibrio cholerae MJ-1236], gi\|22... gi\|229517120, gi... - gi\|229517120\|ref\|ZP_04406566.1\| threonine dehydratase biosynthetic [Vibrio cholerae RC9], gi\|2293461... gi\|229354585, gi... - gi\|229508312\|ref\|ZP_04397816.1\| threonine dehydratase biosynthetic [Vibrio cholerae BX 330286], gi\|2... gi\|227008152, gi... - gi\|227080264\|ref\|YP_002808815.1\| threonine dehydratase [Vibrio cholerae M66-2], gi\|227008152\|gb\|ACP0... gi\|125618262, gi... - gi\|75829906\|ref\|ZP_00759195.1\| COG1171: Threonine dehydratase [Vibrio cholerae MO10], gi\|254851591\|r... gi\|227011970, gi... - gi\|75828122\|ref\|ZP_00757557.1\| COG1171: Threonine dehydratase [Vibrio cholerae O395], gi\|227116520\|r... gi\|121629810, gi... - gi\|75816165\|ref\|ZP_00746643.1\| COG1171: Threonine dehydratase [Vibrio cholerae V52], gi\|121727866\|re... gi\|121548487, gi... - gi\|121587241\|ref\|ZP_01677014.1\| threonine dehydratase [Vibrio cholerae 2740-80], gi\|121548487\|gb\|EAX... gi\|124117944, gi... - gi\|153223897\|ref\|ZP_01954113.1\| threonine dehydratase [Vibrio cholerae MAK 757], gi\|124117944\|gb\|EAY... gi\|153817584, gi... - gi\|153817584\|ref\|ZP_01970251.1\| threonine dehydratase [Vibrio cholerae NCTC 8457], gi\|126511852\|gb\|E... gi\|153821930, gi... - gi\|229508849\|ref\|ZP_04398340.1\| threonine dehydratase biosynthetic [Vibrio cholerae B33], gi\|2293541... gi\|15640059, gi\|... - gi\|9654419\|gb\|AAF93205.1\| threonine dehydratase [Vibrio cholerae O1 biovar El Tor str. N16961], gi\|1... gi\|11356206 - pir\|\|E82374 threonine ammonia-lyase (EC 4.3.1.19) [similarity] - Vibrio cholerae (strain N16961 sero...	0.0	[62..574]	[10..508]
gi\|25291763 - pir\|\|AI2334 threonine ammonia-lyase (EC 4.3.1.19) [similarity] - Nostoc sp. (strain PCC 7120) gi\|17231724, gi\|... - gi\|17231724\|ref\|NP_488272.1\| threonine dehydratase [Nostoc sp. PCC 7120], gi\|17133367\|dbj\|BAB75931.1...	0.0	[62..574]	[4..502]
gi\|60502212, gi\|... - gi\|60502212\|gb\|AAX22214.1\| threonine deaminase [Nicotiana attenuata], gi\|12539611\|gb\|AAG59585.1\|AF22...	0.0	[25..575]	[62..601]
gi\|7473973 - pir\|\|E75502 threonine ammonia-lyase (EC 4.3.1.19) DR0567 [similarity] - Deinococcus radiodurans (str... gi\|6458263, gi\|1... - gi\|6458263\|gb\|AAF10147.1\|AE001915_1 threonine dehydratase, biosynthetic [Deinococcus radiodurans R1]...	0.0	[51..574]	[58..567]
gi\|146452 - gi\|146452\|gb\|AAA24014.1\| threonine dehydratase [Escherichia coli]	0.0	[57..574]	[10..512]

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Predicted Domain #1

Region A:
Residues: [1-77]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSATLLKQPL CTVVRQGKQS KVSGLNLLRL KAHLHRQHLS PSLIKLHSEL KLDELQTDNT  60
   61 PDYVRLVLRS SVYDVIN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [103-212]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPVFSFKLRG AYNMIAKLDD SQRNQGVIAC SAGNHAQGVA FAAKHLKIPA TIVMPVCTPS  60
   61 IKYQNVSRLG SQVVLYGNDF DEAKAECAKL AEERGLTNIP PFDHPYVIAG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1441.0
Match:	1tdj__
Description:	Allosteric threonine deaminase N-terminal domain; Allosteric threonine deaminase C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acetolactate synthase activity	6.50887202511626	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	5.28856942236052	bayes_pls_golite062009
threonine racemase activity	4.44340924206787	bayes_pls_golite062009
threonine synthase activity	3.59927532963055	bayes_pls_golite062009
cysteine synthase activity	3.57860549303214	bayes_pls_golite062009
L-threonine ammonia-lyase activity	3.33109959091277	bayes_pls_golite062009
tryptophan synthase activity	1.99526226543975	bayes_pls_golite062009
lyase activity	1.87743897464083	bayes_pls_golite062009
binding	1.14906798355281	bayes_pls_golite062009
carbon-oxygen lyase activity	0.923824749425553	bayes_pls_golite062009
catalytic activity	0.645256181736122	bayes_pls_golite062009
ammonia-lyase activity	0.476674617721478	bayes_pls_golite062009
protein binding	0.341967829237094	bayes_pls_golite062009
carbon-nitrogen lyase activity	0.249761226675912	bayes_pls_golite062009
transcription regulator activity	0.248470717905239	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [78-102]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESPISQGVGL SSRLNTNVIL KREDL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [213-386]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QGTVAMEILR QVRTANKIGA VFVPVGGGGL IAGIGAYLKR VAPHIKIIGV ETYDAATLHN  60
   61 SLQRNQRTPL PVVGTFADGT SVRMIGEETF RVAQQVVDEV VLVNTDEICA AVKDIFEDTR 120
  121 SIVEPSGALS VAGMKKYIST VHPEIDHTKN TYVPILSGAN MNFDRLRFVS ERAV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1441.0
Match:	1tdj__
Description:	Allosteric threonine deaminase N-terminal domain; Allosteric threonine deaminase C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [387-576]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGEGKEVFML VTLPDVPGAF KKMQKIIHPR SVTEFSYRYN EHRHESSSEV PKAYIYTSFS  60
   61 VVDREKEIKQ VMQQLNALGF EAVDISDNEL AKSHGRYLVG GASKVPNERI ISFEFPERPG 120
  121 ALTRFLGGLS DSWNLTLFHY RNHGADIGKV LAGISVPPRE NLTFQKFLED LGYTYHDETD 180
  181 NTVYQKFLKY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1441.0
Match:	1tdj__
Description:	Allosteric threonine deaminase N-terminal domain; Allosteric threonine deaminase C-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: