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View Structure Prediction Details

Protein: gi|168278008
Organism: synthetic construct
Length: 641 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|168278008.

Description E-value Query
Range
Subject
Range
gi|114558603 - gi|114558603|ref|XP_513685.2| PREDICTED: mannosidase, alpha, class 1A, member 2 isoform 3 [Pan trogl...
0.0 [1..641] [1..641]
gi|73981135 - gi|73981135|ref|XP_849121.1| PREDICTED: similar to Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB...
0.0 [1..641] [1..658]
gi|109014603 - gi|109014603|ref|XP_001113249.1| PREDICTED: mannosidase, alpha, class 1A, member 2 isoform 3 [Macaca...
0.0 [1..641] [1..641]
MA1A2_MOUSE - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB OS=Mus musculus GN=Man1a2 PE=1 SV=1
0.0 [1..641] [1..641]
gi|149030497, gi... - gi|157823986|ref|NP_001099922.1| mannosidase, alpha, class 1A, member 2 [Rattus norvegicus], gi|1490...
0.0 [1..641] [1..641]

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Predicted Domain #1
Region A:
Residues: [1-126]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTPALLPLS GRRIPPLNLG PPSFPHHRAT LRLSEKFILL LILSAFITLC FGAFFFLPDS  60
   61 SKHKRFDLGL EDVLIPHVDA GKGAKNPGVF LIHGPDEHRH REEEERLRNK IRADHEKALE 120
  121 EAKEKL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [127-641]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKSREEIRAE IQTEKNKVVQ EMKIKENKPL PPVPIPNLVG IRGGDPEDND IREKREKIKE  60
   61 MMKHAWDNYR TYGWGHNELR PIARKGHSPN IFGSSQMGAT IVDALDTLYI MGLHDEFLDG 120
  121 QRWIEDNLDF SVNSEVSVFE VNIRFIGGLL AAYYLSGEEI FKIKAVQLAE KLLPAFNTPT 180
  181 GIPWAMVNLK SGVGRNWGWA SAGSSILAEF GTLHMEFIHL SYLTGDLTYY KKVMHIRKLL 240
  241 QKMDRPNGLY PNYLNPRTGR WGQYHTSVGG LGDSFYEYLL KAWLMSDKTD HEARKMYDDA 300
  301 IEAIEKHLIK KSRGGLTFIG EWKNGHLEKK MGHLACFAGG MFALGADGSR ADKAGHYLEL 360
  361 GAEIARTCHE SYDRTALKLG PESFKFDGAV EAVAVRQAEK YYILRPEVIE TYWYLWRFTH 420
  421 DPRYRQWGWE AALAIEKYCR VNGGFSGVKD VYSSTPTHDD VQQSFFLAET LKYLYLLFSG 480
  481 DDLLPLDHWV FNTEAHPLPV LHLANTTLSG NPAVR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1nxcA
Description: Structure of mouse Golgi alpha-1,2-mannosidase IA reveals the molecular basis for substrate specificity among Class I enzymes (family 47 glycosidases)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
mannosyl-oligosaccharide mannosidase activity 7.089685350864 bayes_pls_golite062009
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity 6.95179264736435 bayes_pls_golite062009
mannosidase activity 5.20286438265852 bayes_pls_golite062009
hydrolase activity, hydrolyzing O-glycosyl compounds 4.31319275372149 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 3.65589746311782 bayes_pls_golite062009
hydrolase activity 2.67964748309919 bayes_pls_golite062009
binding 1.49199031708525 bayes_pls_golite062009
catalytic activity 1.31873306707813 bayes_pls_golite062009
cation binding 0.362242764130218 bayes_pls_golite062009
metal ion binding 0.362242764130218 bayes_pls_golite062009
protein binding 0.36081692928767 bayes_pls_golite062009
ion binding 0.355220167272296 bayes_pls_golite062009
calcium ion binding 0.121126738064555 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle