YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|167468939
Organism:	Yersinia pestis FV-1
Length:	407 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|167468939.

Description	E-value	Query Range	Subject Range
gi\|126096730, gi... - gi\|126207938\|ref\|YP_001053163.1\| dihydrolipoyllysine-residue succinyltransferase component of 2-oxog... gi\|32034768 - gi\|32034768\|ref\|ZP_00134893.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|189914931, gi... - gi\|190149800\|ref\|YP_001968325.1\| dihydrolipoyllysine-residue succinyltransferase component of 2-oxog...	0.0	[3..407]	[2..409]
gi\|53732513 - gi\|53732513\|ref\|ZP_00154561.2\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|48868188, gi\|... - gi\|68250263\|ref\|YP_249375.1\| dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydr...	0.0	[3..407]	[2..409]
gi\|144982919 - gi\|144982919\|gb\|EDJ90432.1\| carboxy-terminal protease [Haemophilus influenzae R3021] gi\|145639183, gi... - gi\|145639183\|ref\|ZP_01794790.1\| carboxy-terminal protease [Haemophilus influenzae PittII], gi\|145271... gi\|145631489 - gi\|145631489\|ref\|ZP_01787258.1\| carboxy-terminal protease [Haemophilus influenzae 22.4-21] gi\|46133588 - gi\|46133588\|ref\|ZP_00157429.2\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	0.0	[3..407]	[2..409]
gi\|23467322, gi\|... - gi\|23467322\|ref\|ZP_00122905.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	0.0	[1..407]	[1..407]
gi\|32030043, gi\|... - gi\|32030043\|ref\|ZP_00132963.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	0.0	[1..407]	[1..407]
gi\|77961513, gi\|... - gi\|77961513\|ref\|ZP_00825348.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	0.0	[1..407]	[1..406]
ODO2_HAEIN - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS... ODO2_HAEIN - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS...	0.0	[1..407]	[1..409]
gi\|238726790, gi... - gi\|77978043\|ref\|ZP_00833478.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	0.0	[1..407]	[1..406]
gi\|90438940, gi\|... - gi\|90580055\|ref\|ZP_01235863.1\| dihydrolipoamide acetyltransferase [Vibrio angustum S14], gi\|90438940...	0.0	[3..407]	[2..401]
gi\|15602143, gi\|... - gi\|15602143\|ref\|NP_245215.1\| hypothetical protein PM0278 [Pasteurella multocida subsp. multocida str...	0.0	[1..407]	[1..404]

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Predicted Domain #1

Region A:
Residues: [1-164]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSVDINVPD LPESVADGSV ATWHKKPGDS VKRDEVLVEI ETDKVILEVP ASQDGILDAI  60
   61 LEDEGATVTS RQVLGRIRPS DSSGKPTEEK SQSTESTPAQ RQTASLEEES NETLSPAIRR 120
  121 LIAEHDLDAT AIKGSGVGGR ITREDVDSHL ASRKSASAVV ADAK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	21.39794
Match:	1zy8K
Description:	The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [165-407]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AVAAAAPVLA GRSEKRVPMS RLRKRVAERL LEAKNSTAML TTFNEINMQP IMDLRKQYGE  60
   61 AFEKRHGVRL GFMSFYIKAV VEALKRYPEV NASIDGEDVV YHNYFDVSIA VSTPRGLVTP 120
  121 VLRDVDTLSM ADIEKKIKEL AVKGRDGKLK VEELTGGNFT ITNGGVFGSL MSTPIINPPQ 180
  181 SAILGMHAIK DRPMAVNGQV VILPMMYLAL SYDHRLIDGR ESVGYLVTVK EMLEDPARLL 240
  241 LDV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	89.69897
Match:	1c4tA
Description:	Dihydrolipoamide succinyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity	9.65061123545754	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	9.64995677986911	bayes_pls_golite062009
S-acetyltransferase activity	9.49696044977584	bayes_pls_golite062009
S-acyltransferase activity	8.45313874919036	bayes_pls_golite062009
pyruvate dehydrogenase activity	8.17557182322815	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	6.86215901871647	bayes_pls_golite062009
acyltransferase activity	6.83977352892719	bayes_pls_golite062009
succinyltransferase activity	6.58826720904067	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	6.40483178382327	bayes_pls_golite062009
acetyltransferase activity	6.08159176722072	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.93985773477717	bayes_pls_golite062009
transferase activity, transferring acyl groups	4.60481199262496	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	4.42757758312016	bayes_pls_golite062009
carnitine O-acyltransferase activity	2.87366177129153	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.54513901872655	bayes_pls_golite062009
catalytic activity	1.51562638409295	bayes_pls_golite062009
O-acyltransferase activity	1.33852311685118	bayes_pls_golite062009
O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
carnitine O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
transferase activity	1.08341671157927	bayes_pls_golite062009
carnitine O-acetyltransferase activity	1.00868366840715	bayes_pls_golite062009
binding	0.801074244553007	bayes_pls_golite062009
O-acetyltransferase activity	0.54660034926676	bayes_pls_golite062009
protein binding	0.00454070917775817	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: