YRC Public Data Repository - Protein Structure Prediction

Protein:	PYRE_ECOLU
Organism:	Escherichia coli UMN026
Length:	213 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PYRE_ECOLU.

Description	E-value	Query Range	Subject Range
PYRE_SHISS - Orotate phosphoribosyltransferase OS=Shigella sonnei (strain Ss046) GN=pyrE PE=3 SV=1	213.0	[0..1]	[213..1]
gi\|89093848, gi\|... - gi\|89093848\|ref\|ZP_01166794.1\| orotate phosphoribosyltransferase [Oceanospirillum sp. MED92], gi\|890...	211.0	[0..1]	[213..1]
gi\|254038842, gi... - gi\|254038842\|ref\|ZP_04872894.1\| orotate phosphoribosyltransferase [Escherichia sp. 1_1_43], gi\|22683... gi\|227883810, gi... - gi\|227883810\|ref\|ZP_04001615.1\| orotate phosphoribosyltransferase [Escherichia coli 83972], gi\|22783... gi\|26110718, gi\|... - gi\|26250288\|ref\|NP_756328.1\| orotate phosphoribosyltransferase [Escherichia coli CFT073], gi\|2611071... gi\|75514296 - gi\|75514296\|ref\|ZP_00736604.1\| COG0461: Orotate phosphoribosyltransferase [Escherichia coli 53638]	211.0	[0..1]	[213..6]
PYRE_PHOLL - Orotate phosphoribosyltransferase OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / C... PYRE_PHOLL - Orotate phosphoribosyltransferase OS=Photorhabdus luminescens subsp. laumondii GN=pyrE PE=3 SV=1	211.0	[0..1]	[213..1]
PYRE_SHIF8 - Orotate phosphoribosyltransferase OS=Shigella flexneri serotype 5b (strain 8401) GN=pyrE PE=3 SV=1	211.0	[0..1]	[213..1]
gi\|30043343, gi\|... - gi\|30065082\|ref\|NP_839253.1\| orotate phosphoribosyltransferase [Shigella flexneri 2a str. 2457T], gi... PYRE_SHIFL - Orotate phosphoribosyltransferase OS=Shigella flexneri GN=pyrE PE=3 SV=4 gi\|56480392, gi\|... - gi\|56480392\|ref\|NP_709421.2\| orotate phosphoribosyltransferase [Shigella flexneri 2a str. 301], gi\|5...	211.0	[0..1]	[213..1]
gi\|117625914, gi... - gi\|117625914\|ref\|YP_859237.1\| orotate phosphoribosyltransferase [Escherichia coli APEC O1], gi\|11551... gi\|91213159, gi\|... - gi\|91213159\|ref\|YP_543145.1\| orotate phosphoribosyltransferase [Escherichia coli UTI89], gi\|91074733... gi\|226902677, gi... - gi\|237703413\|ref\|ZP_04533894.1\| orotate phosphoribosyltransferase [Escherichia sp. 3_2_53FAA], gi\|22...	210.0	[0..1]	[213..6]
gi\|75208687 - gi\|75208687\|ref\|ZP_00708984.1\| COG0461: Orotate phosphoribosyltransferase [Escherichia coli B171] gi\|75179725 - gi\|75179725\|ref\|ZP_00699712.1\| COG0461: Orotate phosphoribosyltransferase [Shigella boydii BS512]	210.0	[0..1]	[213..6]
PYRE_SALCH - Orotate phosphoribosyltransferase OS=Salmonella choleraesuis GN=pyrE PE=3 SV=1 PYRE_SALCH - Orotate phosphoribosyltransferase OS=Salmonella choleraesuis (strain SC-B67) GN=pyrE PE=3 SV=1 lcl\|NC_016856.1_... - [gene=pyrE] [protein=orotate phosphoribosyltransferase] [protein_id=YP_005239975.1] [location=comple... PYRE_SALHS - Orotate phosphoribosyltransferase OS=Salmonella heidelberg (strain SL476) GN=pyrE PE=3 SV=1 PYRE_SALSV - Orotate phosphoribosyltransferase OS=Salmonella schwarzengrund (strain CVM19633) GN=pyrE PE=3 SV=1 gi\|197262316, gi... - gi\|197262316\|ref\|ZP_03162390.1\| orotate phosphoribosyltransferase [Salmonella enterica subsp. enteri... PYRE_SALDC - Orotate phosphoribosyltransferase OS=Salmonella dublin (strain CT_02021853) GN=pyrE PE=3 SV=1 gi\|205350134, gi... - gi\|205350134\|gb\|EDZ36765.1\| orotate phosphoribosyltransferase [Salmonella enterica subsp. enterica s... gi\|195632230, gi... - gi\|195632230\|gb\|EDX50714.1\| orotate phosphoribosyltransferase [Salmonella enterica subsp. enterica s... gi\|205344664, gi... - gi\|205344664\|gb\|EDZ31428.1\| orotate phosphoribosyltransferase [Salmonella enterica subsp. enterica s... PYRE_SALNS - Orotate phosphoribosyltransferase OS=Salmonella newport (strain SL254) GN=pyrE PE=3 SV=1 PYRE_SALPB - Orotate phosphoribosyltransferase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=pyrE PE... gi\|205325874, gi... - gi\|205325874\|gb\|EDZ13713.1\| orotate phosphoribosyltransferase [Salmonella enterica subsp. enterica s... gi\|167995206, gi... - gi\|205327073\|gb\|EDZ13837.1\| orotate phosphoribosyltransferase [Salmonella enterica subsp. enterica s... PYRE_SALCH - Orotate phosphoribosyltransferase OS=Salmonella choleraesuis GN=pyrE PE=3 SV=1 gi\|197291365, gi... - gi\|197291365\|gb\|EDY30717.1\| orotate phosphoribosyltransferase [Salmonella enterica subsp. enterica s... gi\|168241912, gi... - gi\|205338713\|gb\|EDZ25477.1\| orotate phosphoribosyltransferase [Salmonella enterica subsp. enterica s... PYRE_SALPB - Orotate phosphoribosyltransferase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=pyrE PE... PYRE_SALTY - Orotate phosphoribosyltransferase OS=Salmonella typhimurium GN=pyrE PE=1 SV=3 PYRE_SALPC - Orotate phosphoribosyltransferase OS=Salmonella paratyphi C (strain RKS4594) GN=pyrE PE=3 SV=1 PYRE_SALTY - Orotate phosphoribosyltransferase OS=Salmonella typhimurium GN=pyrE PE=1 SV=3 gi\|200387791, gi... - gi\|200387791\|ref\|ZP_03214403.1\| orotate phosphoribosyltransferase [Salmonella enterica subsp. enteri... PYRE_SALTY - Orotate phosphoribosyltransferase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN... gi\|204928498, gi... - gi\|204928498\|ref\|ZP_03219697.1\| orotate phosphoribosyltransferase [Salmonella enterica subsp. enteri... PYRE_SALG2 - Orotate phosphoribosyltransferase OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=pyrE PE=3... PYRE_SALEP - Orotate phosphoribosyltransferase OS=Salmonella enteritidis PT4 (strain P125109) GN=pyrE PE=3 SV=1	210.0	[0..1]	[213..1]
PYRE_ECO57 - Orotate phosphoribosyltransferase OS=Escherichia coli O157:H7 GN=pyrE PE=3 SV=3 gi\|209754610, gi... - pir\|\|F86040 orotate phosphoribosyltransferase [imported] - Escherichia coli (strain O157:H7, substra... gi\|194430067, gi... - gi\|194430067\|ref\|ZP_03062572.1\| orotate phosphoribosyltransferase [Escherichia coli B171], gi\|194411... gi\|12518398, gi\|... - gi\|15804183\|ref\|NP_290222.1\| orotate phosphoribosyltransferase [Escherichia coli O157:H7 EDL933], gi... PYRE_SHIB3 - Orotate phosphoribosyltransferase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=pyr... gi\|208807975, gi... - gi\|208807975\|ref\|ZP_03250312.1\| orotate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC4... gi\|190902148, gi... - gi\|75229033\|ref\|ZP_00715617.1\| COG0461: Orotate phosphoribosyltransferase [Escherichia coli B7A], gi... gi\|195936203 - gi\|195936203\|ref\|ZP_03081585.1\| orotate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC4... gi\|192930480, gi... - gi\|75258182\|ref\|ZP_00729630.1\| COG0461: Orotate phosphoribosyltransferase [Escherichia coli E22], gi... gi\|208819481, gi... - gi\|208819481\|ref\|ZP_03259801.1\| orotate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC4... PYRE_SHIBS - Orotate phosphoribosyltransferase OS=Shigella boydii serotype 4 (strain Sb227) GN=pyrE PE=3 SV=1 gi\|208735347, gi... - gi\|208814070\|ref\|ZP_03255399.1\| orotate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC4... gi\|217322180, gi... - gi\|217325959\|ref\|ZP_03442043.1\| orotate phosphoribosyltransferase [Escherichia coli O157:H7 str. TW1... PYRE_ECO5E - Orotate phosphoribosyltransferase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=pyrE PE=3 SV... gi\|254795597, gi... - gi\|254795597\|ref\|YP_003080434.1\| orotate phosphoribosyltransferase [Escherichia coli O157:H7 str. TW... gi\|189358794, gi... - gi\|189358794\|gb\|EDU77213.1\| orotate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC4401]... gi\|168748710, gi... - gi\|188017002\|gb\|EDU55124.1\| orotate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC4113]... gi\|168766062, gi... - gi\|189364629\|gb\|EDU83048.1\| orotate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC4486]... gi\|189369949, gi... - gi\|189369949\|gb\|EDU88365.1\| orotate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC4501]... gi\|189002681, gi... - gi\|189002681\|gb\|EDU71667.1\| orotate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC4076]... gi\|168772392, gi... - gi\|187771742\|gb\|EDU35586.1\| orotate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC4196]... gi\|168798587, gi... - gi\|189378789\|gb\|EDU97205.1\| orotate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC508],... gi\|168785518, gi... - gi\|189374274\|gb\|EDU92690.1\| orotate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC869],... gi\|15833771, gi\|... - gi\|15833771\|ref\|NP_312544.1\| orotate phosphoribosyltransferase [Escherichia coli O157:H7 str. Sakai]...	210.0	[0..1]	[213..1]

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Predicted Domain #1

Region A:
Residues: [1-213]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPYQRQFIE FALSKQVLKF GEFTLKSGRK SPYFFNAGLF NTGRDLALLG RFYAEALVDS  60
   61 GIEFDLLFGP AYKGIPIATT TAVALAEHHD LDLPYCFNRK EAKDHGEGGN LVGSALQGRV 120
  121 MLVDDVITAG TAIRESMEII QANGATLAGV LISLDRQERG RGEISAIQEV ERDYNCKVIS 180
  181 IITLKDLIAY LEEKPEMAEH LAAVKAYREE FGV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.0
Match:	1oroA
Description:	Orotate PRTase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
adenine phosphoribosyltransferase activity	3.1748712918814	bayes_pls_golite062009
uracil phosphoribosyltransferase activity	3.0470646511978	bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity	2.97347277288245	bayes_pls_golite062009
transferase activity	2.73727660668741	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	2.53679639481311	bayes_pls_golite062009
catalytic activity	2.30431811394775	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	2.21367942706564	bayes_pls_golite062009
orotate phosphoribosyltransferase activity	2.02298774328915	bayes_pls_golite062009
ribose phosphate diphosphokinase activity	1.51875493459374	bayes_pls_golite062009
nucleobase binding	1.28671115202467	bayes_pls_golite062009
purine binding	1.24786927434743	bayes_pls_golite062009
amidophosphoribosyltransferase activity	0.932396739123353	bayes_pls_golite062009
binding	0.847513071499147	bayes_pls_golite062009
diphosphotransferase activity	0.749909396904601	bayes_pls_golite062009
nucleic acid binding	0.552133387792911	bayes_pls_golite062009
DNA binding	0.439741935655503	bayes_pls_golite062009
transcription regulator activity	0.396538943915776	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: