YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|188015221, gi...
Organism:	Escherichia coli O157:H7 str. EC4113
Length:	405 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|188015221, gi....

Description	E-value	Query Range	Subject Range
gi\|124115754, gi... - gi\|153213693\|ref\|ZP_01948945.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|229528898, gi... - gi\|229528898\|ref\|ZP_04418288.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat... gi\|229348922, gi... - gi\|229513741\|ref\|ZP_04403203.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat... gi\|194535435, gi... - gi\|75823423\|ref\|ZP_00752925.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|254286797, gi... - gi\|254286797\|ref\|ZP_04961750.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... tr\|D7HAD6\|D7HAD6... - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS... gi\|75819459, gi\|... - gi\|75819459\|ref\|ZP_00749538.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	453.0	[0..3]	[405..2]
gi\|23467322, gi\|... - gi\|23467322\|ref\|ZP_00122905.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	453.0	[0..1]	[405..1]
gi\|227010100, gi... - gi\|227082212\|ref\|YP_002810763.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succin... gi\|229507825, gi... - gi\|229507825\|ref\|ZP_04397330.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat... gi\|9656634, gi\|1... - gi\|9656634\|gb\|AAF95232.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltrans... gi\|229343763, gi... - gi\|229519074\|ref\|ZP_04408517.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat... gi\|229607370, gi... - gi\|229607370\|ref\|YP_002878018.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutara... gi\|75829400, gi\|... - gi\|75829400\|ref\|ZP_00758704.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|147675118, gi... - gi\|75827393\|ref\|ZP_00756828.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|121727380, gi... - gi\|75814758\|ref\|ZP_00745311.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|121586902, gi... - gi\|121586902\|ref\|ZP_01676682.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|124119054, gi... - gi\|153222194\|ref\|ZP_01952973.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|153818382, gi... - gi\|153818382\|ref\|ZP_01971049.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|11257428 - pir\|\|A82121 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase VC2086 ... gi\|229351903, gi... - gi\|229511938\|ref\|ZP_04401417.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat...	453.0	[0..3]	[405..2]
gi\|32030043, gi\|... - gi\|32030043\|ref\|ZP_00132963.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	453.0	[0..1]	[405..1]
gi\|15602143, gi\|... - gi\|15602143\|ref\|NP_245215.1\| hypothetical protein PM0278 [Pasteurella multocida subsp. multocida str...	450.0	[0..1]	[405..1]
gi\|197094545, gi... - gi\|197363068\|ref\|YP_002142705.1\| dihydrolipoamide succinyltransferase [Salmonella enterica subsp. en... gi\|197937902, gi... - gi\|198243386\|ref\|YP_002214705.1\| dihydrolipoyllysine-residue succinyltransferase [Salmonella enteric... gi\|199603528, gi... - gi\|200391083\|ref\|ZP_03217694.1\| dihydrolipoyllysine-residue succinyltransferase [Salmonella enterica... gi\|204929857, gi... - gi\|204929857\|ref\|ZP_03220878.1\| dihydrolipoyllysine-residue succinyltransferase [Salmonella enterica... gi\|194449786, gi... - gi\|194449786\|ref\|YP_002044767.1\| dihydrolipoamide succinyltransferase [Salmonella enterica subsp. en... gi\|194459269, gi... - gi\|194472905\|ref\|ZP_03078889.1\| dihydrolipoyllysine-residue succinyltransferase [Salmonella enterica... gi\|194712419, gi... - gi\|194736917\|ref\|YP_002113843.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of ox... gi\|197250453, gi... - gi\|197250453\|ref\|YP_002145695.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of ox... gi\|205347170, gi... - gi\|205347170\|gb\|EDZ33801.1\| dihydrolipoyllysine-residue succinyltransferase [Salmonella enterica sub... gi\|195629187, gi... - gi\|195629187\|gb\|EDX48555.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|168820135, gi... - gi\|205343027\|gb\|EDZ29791.1\| dihydrolipoyllysine-residue succinyltransferase [Salmonella enterica sub... gi\|194403313, gi... - gi\|194444650\|ref\|YP_002039974.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of ox... gi\|205328906, gi... - gi\|205328906\|gb\|EDZ15670.1\| dihydrolipoyllysine-residue succinyltransferase [Salmonella enterica sub... gi\|238911667 - gi\|238911667\|ref\|ZP_04655504.1\| dihydrolipoamide succinyltransferase [Salmonella enterica subsp. ent... gi\|168230615, gi... - gi\|205334796\|gb\|EDZ21560.1\| dihydrolipoyllysine-residue succinyltransferase [Salmonella enterica sub... gi\|168238880, gi... - gi\|197288334\|gb\|EDY27715.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|168240588, gi... - gi\|205339779\|gb\|EDZ26543.1\| dihydrolipoyllysine-residue succinyltransferase [Salmonella enterica sub... gi\|25286449, gi\|... - gi\|25286449\|pir\|\|AE0591 dihydrolipoamide succinyltransferase component (E2) [imported] - Salmonella ... gi\|16419247, gi\|... - gi\|16764107\|ref\|NP_459722.1\| dihydrolipoamide acetyltransferase [Salmonella typhimurium LT2], gi\|164... lcl\|NC_016856.1_... - [gene=sucB] [protein=dihydrolipoamide acetyltransferase] [protein_id=YP_005236456.1] [location=80505... gi\|29142551, gi\|... - gi\|29142551\|ref\|NP_805893.1\| dihydrolipoamide acetyltransferase [Salmonella enterica subsp. enterica... gi\|16759676 - gi\|16759676\|ref\|NP_455293.1\| dihydrolipoamide acetyltransferase [Salmonella enterica subsp. enterica... gi\|213649150 - gi\|213649150\|ref\|ZP_03379203.1\| dihydrolipoamide acetyltransferase [Salmonella enterica subsp. enter... gi\|213851939 - gi\|213851939\|ref\|ZP_03381471.1\| dihydrolipoamide acetyltransferase [Salmonella enterica subsp. enter... gi\|213999931 - gi\|213999931\|ref\|ZP_03410666.1\| dihydrolipoamide acetyltransferase [Salmonella enterica subsp. enter... gi\|224467079, gi... - gi\|224582552\|ref\|YP_002636350.1\| dihydrolipoamide acetyltransferase [Salmonella enterica subsp. ente... gi\|161615037, gi... - gi\|161615037\|ref\|YP_001589002.1\| dihydrolipoamide acetyltransferase [Salmonella enterica subsp. ente... gi\|62179311, gi\|... - gi\|62179311\|ref\|YP_215728.1\| dihydrolipoamide acetyltransferase [Salmonella enterica subsp. enterica... gi\|56414146, gi\|... - gi\|56414146\|ref\|YP_151221.1\| dihydrolipoamide succinyltransferase [Salmonella enterica subsp. enteri...	450.0	[0..1]	[405..1]
gi\|81240143, gi\|... - gi\|82775995\|ref\|YP_402342.1\| dihydrolipoamide acetyltransferase [Shigella dysenteriae Sd197], gi\|812...	449.0	[0..1]	[405..1]
gi\|194429070, gi... - gi\|75209705\|ref\|ZP_00709913.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|192926821, gi... - gi\|75256436\|ref\|ZP_00728094.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	449.0	[0..1]	[405..1]
gi\|126096730, gi... - gi\|126207938\|ref\|YP_001053163.1\| dihydrolipoyllysine-residue succinyltransferase component of 2-oxog... gi\|32034768 - gi\|32034768\|ref\|ZP_00134893.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|189914931, gi... - gi\|190149800\|ref\|YP_001968325.1\| dihydrolipoyllysine-residue succinyltransferase component of 2-oxog...	449.0	[0..3]	[405..2]
gi\|28805834 - gi\|28805834\|dbj\|BAC59111.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltra... gi\|153838606, gi... - gi\|153838606\|ref\|ZP_01991273.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|28805834, gi\|... - gi\|28897622\|ref\|NP_797227.1\| dihydrolipoamide acetyltransferase [Vibrio parahaemolyticus RIMD 221063...	449.0	[0..3]	[405..2]

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Predicted Domain #1

Region A:
Residues: [1-92]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSVDILVPD LPESVADATV ATWHKKPGDA VVRDEVLVEI ETDKVVLEVP ASADGILDAV  60
   61 LEDEGTTVTS RQILGRLREG NSAGKETSAK SE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.39794
Match:	1pmrA
Description:	LIPOYL DOMAIN FROM THE DIHYDROLIPOYL SUCCINYLTRANSFERASE COMPONENT OF THE 2-OXOGLUTARATE DEHYDROGENASE MULTIENZYME COMPLEX OF ESCHERICHIA COLI, NMR, 25 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydrolipoyllysine-residue acetyltransferase activity	7.74877411346968	bayes_pls_golite062009
S-acetyltransferase activity	7.59642806209362	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	7.45508609960612	bayes_pls_golite062009
pyruvate dehydrogenase activity	7.05950875585975	bayes_pls_golite062009
S-acyltransferase activity	5.24395351180663	bayes_pls_golite062009
acetyltransferase activity	3.55333192628786	bayes_pls_golite062009
acetyl-CoA carboxylase activity	3.31123635155865	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	2.83081843426182	bayes_pls_golite062009
CoA carboxylase activity	2.82233689048595	bayes_pls_golite062009
acyltransferase activity	2.79754636323803	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	2.53708026587542	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.22092493760605	bayes_pls_golite062009
catalytic activity	1.39099902011318	bayes_pls_golite062009
binding	0.988780943163898	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.629490807878017	bayes_pls_golite062009
ligase activity	0.56894584941056	bayes_pls_golite062009
aminomethyltransferase activity	0.377624262164477	bayes_pls_golite062009
protein binding	0.273657523907432	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	0.0222922933292004	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	0.0222922933292004	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [93-159]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKASTPAQRQ QASLEEQNND ALSPAIRRLL AEHNLDASAI KGTGVGGRLT REDVEKHLAK  60
   61 APAKESA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.0
Match:	2cooA
Description:	Solution structure of the e3_binding domain of dihydrolipoamide branched chaintransacylase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [160-405]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAAAAPAAQP ALAARSEKRV PMTRLRKRVA ERLLEAKNST AMLTTFNEVN MKPIMDLRKQ  60
   61 YGEAFEKRHG IRLGFMSFYV KAVVEALKRY PEVNASIDGD DVVYHNYFDV SMAVSTPRGL 120
  121 VTPVLRDVDT LGMADIEKKI KELAVKGRDG KLTVEDLTGG NFTITNGGVF GSLMSTPIIN 180
  181 PPQSAILGMH AIKDRPMAVN GQVEILPMMY LALSYDHRLI DGRESVGFLV TIKELLEDPT 240
  241 RLLLDV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	91.0
Match:	1c4tA
Description:	Dihydrolipoamide succinyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity	9.65061123545754	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	9.64995677986911	bayes_pls_golite062009
S-acetyltransferase activity	9.49696044977584	bayes_pls_golite062009
S-acyltransferase activity	8.45313874919036	bayes_pls_golite062009
pyruvate dehydrogenase activity	8.17557182322815	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	6.86215901871647	bayes_pls_golite062009
acyltransferase activity	6.83977352892719	bayes_pls_golite062009
succinyltransferase activity	6.58826720904067	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	6.40483178382327	bayes_pls_golite062009
acetyltransferase activity	6.08159176722072	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.93985773477717	bayes_pls_golite062009
transferase activity, transferring acyl groups	4.60481199262496	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	4.42757758312016	bayes_pls_golite062009
carnitine O-acyltransferase activity	2.87366177129153	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.54513901872655	bayes_pls_golite062009
catalytic activity	1.51562638409295	bayes_pls_golite062009
O-acyltransferase activity	1.33852311685118	bayes_pls_golite062009
O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
carnitine O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
transferase activity	1.08341671157927	bayes_pls_golite062009
carnitine O-acetyltransferase activity	1.00868366840715	bayes_pls_golite062009
binding	0.801074244553007	bayes_pls_golite062009
O-acetyltransferase activity	0.54660034926676	bayes_pls_golite062009
protein binding	0.00454070917775817	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: